Antiviral activityin vitro ofCupressus sempervirens on two human retroviruses HIV and HTLV

Amouroux, Pierre; Duma, Jean; Lamaison, Jean‐Louis

doi:10.1002/(sici)1099-1573(199808)12:5<367::aid-ptr301>3.0.co;2-n

Cited by 27 publications

(12 citation statements)

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“…Corilagin (82) and geraniin (83) represented in Figure 13 are the two ellagitannins that possessed anti-HIV activity and have extracted from Phyllanthus amarus roots [335]. From the plant Cupressus sempervirens, a proanthocyanidin compound is obtained containing anti-HIV property [336]. Figure 14.…”

Section: Proteinsmentioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Kaur

Sharma

Gupta³

et al. 2020

Preprint

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Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.

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Section: Proteinsmentioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Kaur

Sharma

Gupta³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Chemical studies on CS revealed the presence of polyphenols (1-7), flavonoids (8) and flavone glycosides (9)(10)(11)(12). Bioflavonoid including amentoflavone, cupressuflavone, 4″′-mono-Omethyl amentoflavone, hinokiflavone, isocryptomerin and podocarpusflavone A has also been reported from this plant (13)(14)(15)(16)(17) [4]. As per reported in several studies, essential oils from cones and fruits mainly contained volatile monoterpenes (18-28) and sesquiterpenes (29-32) [5-8].…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…The MeOH extract of leaves of this plant was shown to exert hepatoprotective activity against normal and CCl(4)-rats. The MeOH extract and isolated phenolic compounds exhibited free radical scavenging activity against stable 2,2-diphenyl-2-picrylhydrazyl (DPPH) in comparison to α-tocopherol and butylated hydroxyl toluene (BHT) as standard antioxidants using ESR technique [15]. Recently, Siddique et al…”

Section: Pharmacologymentioning

confidence: 99%

Biomedicinal and Chemical Profile of Cupressus sempervirens: A Mini Review

Mf¹,

Ahamad²,

Rawat³

2017

Insights Biomed

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“…For instance, the proanthocyanidin-rich fraction of C. sempervirens was found to have in vitro antiviral activity against two retroviruses, human immunodeficiency virus and human T-lymphotropic virus III B [24]. The inhibitory activity of the fruit essential oil of C. sempervirens subsp.…”

Section: Antimicrobial and Antiviral Activitymentioning

confidence: 99%