Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus

Graham, Simon P.; Cheong, Yuen-Ki; Furniss, Summer; Nixon, Emma; Smith, Joseph A.; Yang, Xiuyi A.; Fruengel, Rieke; Hussain, Sabha; Tchórzewska, Monika A.; Ragione, Roberto M. La; Ren, Guogang

doi:10.3390/nano11082120

Cited by 6 publications

(7 citation statements)

References 34 publications

(44 reference statements)

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“…In addition to the antibacterial effect, Cu-based NPs also have potent antifungal activity; for example, Ghasemian et al studied the antifungal activity of Cu-based NPs in killing pathogenic fungi, such as Alternaria alternata , Aspergillus flavus , Fusarium solani , and Penicillium chrysogenum , and found that 8 nm has better antifungal activity with a minimum inhibitory concentration of 40–80 mg/L. Besides, Cu-based NPs also have a high ability to resist viral infection, such as Hepatitis C Virus, Porcine reproductive and respiratory syndrome viruses (PRRSV), and SARS-CoV-2 . Therefore, the strong microbicidal properties make Cu-based NPs widely used in the biomedicine industry as well as agricultural industry such as plants and livestock fields. , …”

Section: Application and Toxicity Of Copper-based Nanoparticlesmentioning

confidence: 99%

“…Besides, Cu-based NPs also have a high ability to resist viral infection, such as Hepatitis C Virus, Porcine reproductive and respiratory syndrome viruses (PRRSV), and SARS-CoV-2 . Therefore, the strong microbicidal properties make Cu-based NPs widely used in the biomedicine industry as well as agricultural industry such as plants and livestock fields. , …”

Section: Application and Toxicity Of Copper-based Nanoparticlesmentioning

confidence: 99%

“…190 Therefore, the strong microbicidal properties make Cu-based NPs widely used in the biomedicine industry 196 as well as agricultural industry such as plants and livestock fields. 129,195 6.2. Toxicity of Copper-Based Nanoparticles.…”

Section: Copper and Human Healthmentioning

confidence: 99%

See 2 more Smart Citations

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Zhen

Chen

et al. 2022

J. Agric. Food Chem.

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The extensive use of high-concentration copper (Cu) in feed additives, fertilizers, pesticides, and nanoparticles (NPs) inevitably causes significant pollution in the ecological environment. This type of chain pollution begins with animal husbandry: first, Cu accumulation in animals poisons them; second, high Cu enters the soil and water sources with the feces and urine to cause toxicity, which may further lead to crop and plant pollution; third, this process ultimately endangers human health through consumption of livestock products, aquatic foods, plants, and even drinking water. High Cu potentially alters the antibiotic resistance of soil and water sources and further aggravates human disease risks. Thus, it is necessary to formulate reasonable Cu emission regulations because the benefits of Cu for livestock and plants cannot be ignored. The present review evaluates the potential hazards and benefits of high Cu in livestock, the environment, the plant industry, and human health. We also discuss aspects related to bacterial and fungal resistance and homeostasis and perspectives on the application of Cu−NPs and microbial high-Cu removal technology to reduce the spread of toxicity risks to humans.

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Section: Application and Toxicity Of Copper-based Nanoparticlesmentioning

confidence: 99%

Section: Application and Toxicity Of Copper-based Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Zhen

Chen

et al. 2022

J. Agric. Food Chem.

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“…In this study, CuO nanoparticles have been modi ed with BA as a model system and molecular dynamics simulation has also been performed for analyzing diffusivity, level of agglomeration, aggregation dependent on viscosity and interaction kinetics. 25 . Therefore, by conducting simulations on CuO dispersion in aqueous medium with surfactant (that holds properties of inhibition) can help in understanding the inhibiting science of these modi ed particles and how it degrades the production of viruses.…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics simulation on surface modification of a quantum scaled CuO nano-clusters to support their experimental studies

Loya

Stair

Uddin

et al. 2022

Preprint

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Interest in nanoparticle modification using functional chemicals has increased rapidly, as it is allowing more freedom of physiochemical tuning of the nanoparticle’s surfaces into biomedically oriented and designated properties. However, the observation and detection of the thin molecular layers on the nanoparticle surface are very challenging under current analytical facilities. The focus of this research is to demonstrate fundamental interactions between the surface treated nanoparticles and their host liquid media using lab-based experimentation and simulation. In this research, investigation has been carried out on analyzing the surface compatibility and the diffusivity of modified CuO nanoparticles with short-chain carboxylate-terminated molecules in biofluids. Moreover, during the current Covid-19 pandemic, the Cu/CuONPs have proved effective in killing SARS-CoV1/2 and other airborne viruses. This research was conducted at the molecular level with joint consideration of experimental and simulation studies for characterization of variables. Experimental tests conducted using Fourier Transmission Infrared (FTIR) demonstrated several ranges of interest from FTIR responses, specifically, detection of three major carboxylate attachments (i.e., 1667 cm-1 -1609 cm-1, 1668 cm-1 - 1557 cm-1, etc.) were found. From simulation, similar attachment styles were observed by the LAMMPS simulation package that mimicked similar agglomerations with a predicted diffusion coefficient as recorded to be 2.28E-9m2/s. Viscosities of modified nanofluids were also compared with unmodified nanofluids for defining aggregation kinetics.

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“…Today, in the current Covid-19 pandemic, the Cu/CuONPs have proved effective in killing SARS-CoV1/2 and other airborne viruses, as investigated by Ren and Lin in their latest research outcomes conducted in 2021 25 . Therefore, by conducting simulations on CuO dispersion in aqueous medium with a surfactant (that holds properties of inhibition) can help in understanding the inhibiting science of these modified particles and how it degrades the production of viruses.…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics simulation on surface modification of quantum scaled CuO nano-clusters to support their experimental studies

Loya

Stair

Uddin

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Interest in nanoparticle modification using functional chemicals has increased rapidly, as it allows more freedom of physiochemical tuning of the nanoparticle’s surface into biomedically oriented and designated properties. However, the observation and detection of the thin molecular layers on the nanoparticle surface are very challenging under current analytical facilities. The focus of this research is to demonstrate fundamental interactions between the surface treated nanoparticles and their host liquid media using lab-based experimentation and simulation. In this research, investigation has been carried out on analyzing the surface compatibility and the diffusivity of modified CuO nanoparticles (CuONPs) with short-chain carboxylate-terminated molecules in biofluids. Moreover, during the current Covid-19 pandemic, the Cu/CuONPs have proved effective in killing SARS-CoV1/2 and other airborne viruses. This research was conducted at the molecular level with joint consideration of experimental and simulation studies for characterization of variables. Experimental tests conducted using Fourier Transform Infrared (FTIR) spectroscopy demonstrated several spectral ranges of interest, specifically, detection of three major carboxylate attachments (i.e., 1667–1609 cm−1, 1668–1557 cm−1, etc.) were found. From simulation, similar attachment styles were observed by the LAMMPS simulation package that mimicked similar agglomerations with a predicted diffusion coefficient as recorded to be 2.28E−9 m2/s. Viscosities of modified nanofluids were also compared with unmodified nanofluids for defining aggregation kinetics.

show abstract

Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus

Cited by 6 publications

References 34 publications

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Molecular dynamics simulation on surface modification of a quantum scaled CuO nano-clusters to support their experimental studies

Molecular dynamics simulation on surface modification of quantum scaled CuO nano-clusters to support their experimental studies

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