Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis

Barry, John A.; Kuczmierczyk, Andrzej R.; Hardiman, Paul

doi:10.1093/humrep/der197

Cited by 269 publications

(240 citation statements)

References 36 publications

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“…Adrenal Hyperplasia (CAH) or Polycystic Ovary Syndrome (PCOS) revealed higher rates of anxiety disorders (Barry et al, 2011;Mansson et al, 2008;Mueller et al, 2010) and cognitively faster processing of threat in some cases (Ernst et al, 2007;Mueller et al, 2009a). Such results strongly support the hypothesis that mood and anxiety disorders are often associated with disorders of gonadal dysregulation.…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 83%

“…psychopathologies include anxiety and depression as well as eating disorders relative to women without this condition (Barry et al, 2011;Mansson et al, 2008).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

“…Despite the high prevalence of anxiety and depression symptoms in PCOS (Barry et al, 2011), surprisingly, we are aware of only one neurocognitive study of patients with PCOS that assessed emotional functioning. Participants were asked to rate stimulus pictures as either neutral or negative while undergoing fMRI scanning.…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

“…The reviewed literature consistently indicates higher levels of depression and anxiety across conditions with a strong, inherent hormonal component. While most studies documented the presence of psychopathology in affected individuals (Barry et al, 2011;Bruining et al, 2009;Downey et al, 1989;Fliegner et al, 2013;Halbreich et al, 2003;Mueller et al, 2010;Skakkebaek et al, 2014;Woods and Mitchell, 2005), another study found state measures to directly correlate with circulating androgens (Livadas et al, 2011). Yet another line of work supports this model by showing that testosterone administration may be beneficial for mood status in hypogonadal men when their hormonal levels are below the normal range of values but less beneficial if hormonal levels are within the normal range (Alexander et al, 1997).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

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Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 83%

“…psychopathologies include anxiety and depression as well as eating disorders relative to women without this condition (Barry et al, 2011;Mansson et al, 2008).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

See 2 more Smart Citations

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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“…Получены дан-ные о высокой частоте выявления у женщин с СПКЯ ряда психических нарушений [11]. Взаимосвязь пси-хических и физиологических проявлений СПКЯ остается малоизученной, опубликованные по этой проблеме данные противоречивы, и единой точки зрения пока не существует [12,13].…”

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Sexual disturbances in women with polycystic ovary syndrome

Ильина¹,

Grodnitskaya²,

Latyshkevich³

et al. 2016

Probl. reprod.

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1 ГБУЗ Москвы «Центр планирования семьи и репродукции Департамента здравоохранения Москвы», Москва, Россия, 117209; 2 Московский научно-исследовательский институт психиатрии -филиал ФГБУ «ФМИЦПН» Минздрава России, Москва, Россия, 107076; 3 Кафедра акушерства и гинекологии педиатрического факультета ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия, 117997;4 Институт клинической эндокринологии ФГБУ «Эндокринологический научный центр» Минздрава России, Москва, Россия, 117036Цель исследования -изучение сексуальной сферы пациенток с синдромом поликистозных яичников (СПКЯ), ее связи с эмоциональным состоянием и физиологическими параметрами. Материал и методы. В исследование на базе ГБУЗ Москвы «Центр планирования семьи и репродукции Департамента здравоохранения Москвы» вошли 90 ведущих половую жизнь женщин репродуктивного возраста с СПКЯ (ESHRE/ASRM). Контрольную группу составили 18 здоровых, ведущих половую жизнь женщин репродуктивного возраста. Проведено клинико-лабораторно-инструментальное, а также комплексное психопатологическое обследование (MINI-6, HADS, СФЖ и разработанное на ее основе полуструктурированное интервью). Обработка данных осуществлялась с применением методов базовой и непараметрической статистики. Результаты и обсуждение. Нарушения в различных аспектах сексуальной сферы выявлены у 55 (61,11%) пациенток с СПКЯ и 10 (55,56%) -в контрольной группе. Субъективно признавали наличие проблем 34 (37,78%) пациентки с СПКЯ и 4 (22,22%) -в контрольной группе. Выявлены значимые различия в показателях выделения влагалищной слизи и способности к оргазму между группой СПКЯ и группой контроля (U-критерий Манна-Уитни; p<0,05). Установлены значимые различия в способности к оргазму и в физической реакции на завершение полового акта и менее значимые в половой активности и удовлетворенности сексуальной жизнью между пациентками с СПКЯ и тревожными и/или депрессивными нарушениями и пациентками без сопутствующих эмоциональных нарушений (U-критерий Манна-Уитни; p<0,05 и p<0,1). Выявлена связь сексуальных нарушений с семейным положениием, уровнем образования, а также текущим желанием забеременеть. Не отмечено связи сексуальных нарушений с индексом массы тела, фенотипом СПКЯ, прошлым сексуальным опытом, наличием детей. Objective -to study the sexuality of women with PCOS, its relationship with the emotional state and physiological parameters. Material and methods. The study was conducted on the base of Centre of Family Planning and Reproduction, Moscow City health protection Department. It involved 90 sexually active women of reproductive age with PCOS (ESHRE/ASRM). The control group consisted of 18 healthy, sexually active women of reproductive age. Clinical, laboratory, instrumental, and integrative psychopathological examination (MINI-6, HADS, SFF and developed from SFF semi-structured interview) were performed. Data processing was carried out with the use of basic and non-parametric statistical methods. Results and discussion. 55 (61.11%) pa...

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Association Between Mental Health and Reproductive System Disorders in Women

et al. 2023

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ImportanceReproductive system and mental health disorders are commonly comorbid in women. Although the causes of this overlap remain elusive, evidence suggests potential shared environmental and genetic factors associated with risk.ObjectiveTo investigate the comorbidity between psychiatric and reproductive system disorders, both as broad diagnostic categories and among specific pairs of diagnoses.Data SourcePubMed.Study SelectionObservational studies published between January 1980 and December 2019 assessing prevalence of psychiatric disorders in women with reproductive system disorders and prevalence of reproductive system disorders in women with psychiatric disorders were included. The study did not include psychiatric and reproductive disorders triggered by life events (eg, trauma, infection, surgery) to address potential confounding.Data Extraction and SynthesisA search yielded 1197 records, of which 50 met the inclusion criteria for the qualitative and 31 for the quantitative synthesis in our study. A random-effects model was used for data synthesis and Egger test and I2 to assess study bias and heterogeneity. Data were analyzed from January to December 2022. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline.Main Outcomes and MeasuresPsychiatric and reproductive system disorders.ResultsA total of 1197 records were identified, of which 50 met the inclusion criteria for qualitative and 31 for quantitative synthesis. Diagnosis of a reproductive system disorder was associated with a 2- to 3-fold increased odds of having a psychiatric disorder (lower bound odds ratio [OR], 2.00; 95% CI, 1.41-2.83; upper bound OR; 2.88; 95% CI, 2.21-3.76). The analysis focused on specific diagnoses described in the literature and found that polycystic ovary syndrome was associated with increased odds of depression (population-based studies OR, 1.71; 95% CI, 1.19-2.45; clinical studies OR, 2.58; 95% CI, 1.57-4.23) and anxiety (population-based studies OR, 1.69; 95% CI, 1.36-2.10; clinical studies OR, 2.85; 95% CI, 1.98-4.09). Chronic pelvic pain was also associated with both depression (OR, 3.91; 95% CI, 1.81-8.46) and anxiety (OR, 2.33; 95% CI, 1.33-4.08). Few studies investigated risk of other reproductive system disorders in women with psychiatric disorders, or reverse associations (risk of reproductive system disorder among women with a psychiatric diagnosis).Conclusions and RelevanceIn this systematic review and meta-analysis, a high rate of reported co-occurrence between psychiatric and reproductive disorders overall was observed. However, data for many disorder pairs were limited. The available literature focused overwhelmingly on affective disorders in polycystic ovary syndrome, overlooking a substantial portion of disease overlap. As such, the associations between the majority of mental health outcomes and conditions of the female reproductive system are largely unknown.

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Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis

Cited by 269 publications

References 36 publications

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Sexual disturbances in women with polycystic ovary syndrome

Association Between Mental Health and Reproductive System Disorders in Women

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