Aplastic Anemia in Pregnancy

Rathore, Swati; Pramanick, Angsumita; Regi, Annie; Lionel, Jessie

doi:10.1007/s13224-013-0431-1

Cited by 10 publications

(13 citation statements)

References 8 publications

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“… 58 In pregnancy, supportive management with transfusions to hemoglobin >8 g/dL and platelet count >20×10 9 /L is recommended. 6 Additionally, there are reports of patients successfully treated with prednisolone, cyclosporine, and GCSF. 5 , 59 Regarding the use of ATG in pregnancy, there is little published experience.…”

Section: Maternal and Fetal Considerations In Aplastic Anemia In Pregmentioning

confidence: 99%

“…Mode of delivery should be carefully considered. 6 Vaginal delivery is preferred, because even with significant thrombocytopenia, hemostasis can typically be achieved with appropriate uterine contraction after delivery. 73 A platelet count >20×10 9 /L is deemed acceptable 74 for vaginal delivery and >50×10 9 /L for cesarean delivery.…”

Section: Perinatal Implications Of Aplastic Anemiamentioning

confidence: 99%

“… 4 Growth restriction affects the fetus, and neonatal sepsis is more prevalent among babies from mothers with AA. 5 A causal relationship between pregnancy and AA has not been conclusively established; 6 however, women with AA can become pregnant, since there is no compromise of fertility. In these cases, obstetric and neonatal complications range between 12% and 33%.…”

Section: Introductionmentioning

confidence: 99%

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Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

Riveros-Pérez

Hermesch

Barbour

et al. 2018

IJWH

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Aplastic anemia is a hematologic condition occasionally presenting during pregnancy. This pathological process is associated with significant maternal and neonatal morbidity and mortality. Obstetric and anesthetic management is challenging, and treatment requires a coordinated effort by an interdisciplinary team, in order to provide safe care to these patients. In this review, we describe the current state of the literature as it applies to the complexity of aplastic anemia in pregnancy, focusing on pathophysiologic aspects of the disease in pregnancy, as well as relevant obstetric and anesthetic considerations necessary to treat this challenging problem. A multidisciplinary-team approach to the management of aplastic anemia in pregnancy is necessary to coordinate prenatal care, optimize maternofetal outcomes, and plan peripartum interventions. Conservative transfusion management is critical to prevent alloimmunization. Although a safe threshold-platelet count for neuraxial anesthesia has not been established, selection of anesthetic technique must be evaluated on a case-to-case basis.

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Section: Maternal and Fetal Considerations In Aplastic Anemia In Pregmentioning

confidence: 99%

Section: Perinatal Implications Of Aplastic Anemiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

Riveros-Pérez

Hermesch

Barbour

et al. 2018

IJWH

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“…Unfortunately, most of the current literature has been limited to case reports, with few studies exploring risk factors and perinatal complications. 4 Pathophysiological mechanisms underlying the association between aplastic anemia and pregnancy have not been clearly elucidated. 4 It is known that estrogens increase plasma volume in pregnancy more than red-blood-cell production, resulting in anemia of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Management of Aplastic Anemia in Pregnancy: A Case Report

Djusad

Malano

2020

Indones J Obstet Gynecol

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Aplastic anemia was first recognized by Ehrlich in 1888, although the pathogenesis of aplastic anemia has remained elusive. Aplastic anemia is a subtype of anemia characterized by pancytopenia and a hypocellular bone marrow which are the risk factor can be due to chemicals, drugs, infections, irradiation, leukemia, and inherited disorders. There is universal agreement that pregnancy complicated by aplastic anemia is a serious condition. The risk to the mother is mainly in the form of hemorrhage meanwhile the fetus may suffer from growth restriction and even intrauterine death. Most of the fetal complications are due to maternal anemia. We here present one cases of pregnancy complicated by aplastic anemia, which were seen within 3 months at our hospital. This high incidence is because the hospital is a top national care referral unit with good hematology and blood bank support. Keyword: aplastic anemia, pregnancy, pancytopenia Abstrak Anemia aplastik pertama kali dikenali oleh Ehrlich pada tahun 1888, walaupun patogenesis anemia aplastik masih sulit dipahami. Anemia aplastik adalah subtipe anemia yang ditandai dengan pansitopenia dan hiposeluler sumsum tulang yang merupakan faktor risiko yang dapat disebabkan oleh bahan kimia, obat-obatan, infeksi, iradiasi, leukemia, dan kelainan bawaan. Terdapat kesepakatan universal bahwa komplikasi kehamilan berupa anemia aplastik merupakan kondisi serius. Risiko kepada ibu hamil terutama dalam bentuk perdarahan sementara janin dapat mengalami hambatan dalam pertumbuhan dan bahkan kematian dalam kandungan. Sebagian besar komplikasi janin disebabkan oleh anemia pada maternal. Kami di sini menyajikan satu kasus komplikasi kehamilan berupa anemia aplastik, yang ditemukan dalam waktu 3 bulan di rumah sakit kami. Kejadian yang tinggi ini karena rumah sakit adalah unit rujukan perawatan nasional teratas dengan hematologi yang baik dan dukungan bank darah.

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“…Although the causal relationship between AA and pregnancy has not been conclusively established. 18 Prescribing the use of Immunosuppressive agents or involving particular procedure of hematopoietic stem cell transplantation are inadvisable for treating the disorder during pregnancy as they have potential toxicity effect to growing fetus. 11,13 There is no agreement about the optimal supportive care, treatment regime and even no clear guidelines are provided for the management of aplastic anemia disorder during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic aplastic anemia: a rare case report in Jammu and Kashmir region, India

Sharma

Upma²,

Mani

2019

Int J Reprod Contracept Obstet Gynecol

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Idiopathic aplastic anemia is a pancytopenia disorder that is a rare but life threatening for both mother and fetus during pregnancy. Association of aplastic anemia with pregnancy is unclear but considered to be interrelated. Bone marrow transplantation is the most effective treatment for adult aplastic anemia but is inadvisable to perform during pregnancy because of the teratogenic effect of immunosuppressive agents or radiation therapy to the growing fetus. Supportive care, withdrawal from offending drugs and involving erythrocytes and platelets transfusion is a promising way to save the life. Here author present a case report of 36-year-old lady with idiopathy aplastic anemia. In this case medical investigation revealed severe anemia of unknown origin. The patient was treated with hematinics, blood transfusion and glucocorticoids. A healthy baby was delivered without evidence of hemolysis at her eight month and one week of pregnancy, the patient recovered and discharged with normal incidence. Being a rare case, it becomes a necessity to report such life-threatening disorder and management. Moreover, to our knowledge this is the first case reported of its kind from Jammu and Kashmir Division of India.

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Aplastic Anemia in Pregnancy

Cited by 10 publications

References 8 publications

Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

Management of Aplastic Anemia in Pregnancy: A Case Report

Idiopathic aplastic anemia: a rare case report in Jammu and Kashmir region, India

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