Applicability of Compensatory Cognitive Training in Epilepsy to Low Resource and Literacy Settings

Sharma, Shivani; Nehra, Ashima; Tripathi, Manjari

doi:10.4103/0028-3886.319233

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Additionally, this could help ensure a wider outreach of neuropsychology services to patients who are unable to travel to tertiary care centres due to financial constraints. This in turn could help provide continuum of care from a neuropsychology perspective in a country wherein neuropsychology is still in its nascent stages [10] , [62] , [63] .…”

Section: Discussionmentioning

confidence: 99%

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Suspend or amend? Randomized controlled trial on neuropsychological rehabilitation for epilepsy: A COVID-19 impact

Sharma

Nehra

Pandey

et al. 2022

Epilepsy & Behavior Reports

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COVID-19 caused devastating effects of human loss and suffering along with disruption in clinical research, forcing reconceptualization and modification of studies. This paper attempts to outline the steps followed and detail the modifications undertaken to deal with the impacts of the pandemic on the first ongoing randomized controlled trial on effectiveness of neuropsychological rehabilitation in adult patients with drug resistant epilepsy in India. All modifications were based on evolving guidelines and circumstantial context and were planned, reviewed and approved by important stakeholders. Results obtained from the trial need to be interpreted and analysed within this context. These modifications have implications for wider outreach of neuropsychology services in India.

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Section: Discussionmentioning

confidence: 99%

“… [9] . However, the available literature is from resource rich settings which has limited direct evidence for applicability in lower income and literacy countries such as India [10] .…”

Section: Introductionmentioning

confidence: 99%

Suspend or amend? Randomized controlled trial on neuropsychological rehabilitation for epilepsy: A COVID-19 impact

Sharma

Nehra

Pandey

et al. 2022

Epilepsy & Behavior Reports

Self Cite

View full text Add to dashboard Cite

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Factors associated with global cognitive impairment in epilepsy patients: a cross-sectional study in Mataram, Indonesia

2022

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BACKGROUND Cognitive impairment is a major complication of epilepsy. This study aimed to investigate the factors associated with the prevalence of cognitive impairment in patients with epilepsy in Mataram, Indonesia. METHODS This cross-sectional study involved 155 consecutive outpatients with epilepsy at Mataram General Hospital, Mutiara Sukma Mental Hospital, and Siti Hajar Hospital, Mataram, Indonesia between September 2017 and August 2020. Data on the patient’s demographic characteristics, epilepsy, treatment variables, and global cognitive status were collected. The association between the determinants of epilepsy-associated cognitive impairment and the prevalence of epilepsy-associated global cognitive impairment was analyzed using logistic regression. RESULTS The prevalence of epilepsy-associated global cognitive impairment was 83.9% and related to a low level of education (odds ratio [OR] = 5.24, 95% confidence interval [CI] = 1.93–14.20), early age at onset (OR = 7.85, 95% CI = 0.82–33.79), and long duration of epilepsy (OR = 8.47, 95% CI = 1.95–36.88). CONCLUSIONS A high prevalence of epilepsy-associated global cognitive impairment was observed in Mataram and was associated with a low level of education, early age at onset, and long duration of epilepsy.

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A Multicenter, Cross-Sectional, Observational Study on Epilepsy and its Management Practices in India

et al. 2022

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Background:Although epilepsy is a common neurological condition, there is paucity of nationwide data on treatment patterns and sociodemographic and clinical factors affecting treatment decisions in India.Objective:To assess clinical profiles, usage pattern of antiepileptic drugs (AEDs), and seizure control among patients with epilepsy in India.Methods:This was a cross-sectional, observational, multicenter study on adult patients with epilepsy who were on AEDs for at least six months before enrollment. Data were collected from patient interviews and medical records.Results:Out of 800 enrolled patients, a majority (69.0%) had generalized onset seizure in the six months before enrollment. The median age at epilepsy onset was 20.0 (1.0–64.0) years; 40.0% of the patients were females, 48.5% were married, 99.1% were literate, and 67.0% belonged to the lower or upper-middle socioeconomic class. Overall, 459 patients (57.4%) received AEDs as combination therapy. Most patients received levetiracetam (37.0%), sodium valproate (18.5%), carbamazepine (17.3%), or phenytoin (13.8%) as monotherapy, and clobazam (59.7%), levetiracetam (52.9%), carbamazepine (26.4%), sodium valproate (24.8%), or phenytoin (24.0%) in combination therapy. Quality of life was comparable for first- and third-generation AEDs. Adverse drug reactions were mostly attributed to dose modification or switching between drugs. No serious adverse drug reactions or new safety concerns were identified.Conclusions:Findings from this large, cross-sectional, observational, multicenter study indicate that first-generation AEDs sodium valproate and phenytoin continued to be used in a substantial number of patients on monotherapy and combination therapy in India, even though an increasing trend toward use of second-generation AEDs was noted in clinical practice.

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Applicability of Compensatory Cognitive Training in Epilepsy to Low Resource and Literacy Settings

Cited by 4 publications

References 36 publications

Suspend or amend? Randomized controlled trial on neuropsychological rehabilitation for epilepsy: A COVID-19 impact

Suspend or amend? Randomized controlled trial on neuropsychological rehabilitation for epilepsy: A COVID-19 impact

Factors associated with global cognitive impairment in epilepsy patients: a cross-sectional study in Mataram, Indonesia

A Multicenter, Cross-Sectional, Observational Study on Epilepsy and its Management Practices in India

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