Application of Artificial Neural Networks in Prediction of Diclofenac Sodium Release From Drug-Modified Zeolites Physical Mixtures and Antiedematous Activity Assessment

Krajišnik, Danina; Stepanović-Petrović, Radica; Tomić, Maja; Micov, Ana; Ibrić, Svetlana; Milić, Jela

doi:10.1002/jps.23869

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…Previous research has demonstrated that zeolites may play an important role in the antibacterial and anti-inflammatory processes [12]. It has been shown that the anti-inflammatory effect induced by diclofenac sodium was intensified and prolonged in the presence of zeolite [13]. In another study, modulatory effect of zeolite on serotonin receptors has been demonstrated in mice brains including tumors.…”

Section: Introductionmentioning

confidence: 94%

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Yapışlar

Taşkın

Ozdas

et al. 2015

Biol Trace Elem Res

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Growing evidence has been reported on adriamycin (ADR) hepatotoxicity in literature. Hepatotoxicity caused by the use of drugs has a serious undesirable effect in the cure of cancer patients that needs to be eliminated. The exact mechanism of ADR on non-cancerous tissue still remains to be a mystery. The zeolite (clinoptilolite) minerals form a complex group of aluminosilicates that often occur as accessory minerals in intermediate and basic rocks. In light of this information, we investigated the possible anti-inflammatory and anti-apoptotic effects of clinoptilolite in ADR that is inducing the toxicity in primary liver cell culture. Primary liver cell culture from rat was used in the study. We had three experiment groups including the following: (1) cells treated only with 50 μM ADR for 24 h, (2) cells treated with the 50 μM ADR for 24 h and then treated with 10(-4) M zeolite for 1 h, and (3) cells were incubated with 50 μM ADR for 24 h and then incubated with 10(-4) M zeolite for 24 h to test its long-term effects. After that, western blotting was performed in order to evaluate protein expression levels of several inflammation markers including IL-1β, tumor necrosis factor (TNF)-α, and nuclear factor kappa B (NF-κB), and immunohistochemistry was carried out to detect apoptosis in liver cell culture. Also, TdT-dUTP Terminal Nick-End Labeling (TUNEL) method was used for detecting apoptosis. We found elevated levels of inflammatory protein and apoptotic markers in ADR-administered cells (p < 0.05). Inflammatory and apoptotic markers decreased significantly after treated with zeolite (p < 0.05). The present study was pointed out that ADR causes hepatotoxicity via apoptosis and/or inflammation processes resulting from initiator NF-κB and TNF which causes proinflammatory mediators such as IL-1β. Elevation of inflammation might give rise to trigger apoptosis. Clinoptilolite counteracted the apoptosis and inflammation induced by ADR arising from the decrease in NF-κB, TNF-α, and IL-1β protein levels.

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Section: Introductionmentioning

confidence: 94%

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Yapışlar

Taşkın

Ozdas

et al. 2015

Biol Trace Elem Res

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“…La generación de varios lotes de medicamentos requiere el control de cada uno para comprobar una alta calidad de producto. Estos controles se hacen usando ensayos de disolución (41), química analítica y física. Estas mediciones generan un gran volumen de datos que pueden ser usado por redes neuronales para mejorar los procesos de fabricación.…”

Section: Descubrimiento De Compuestos Farmacéuticosunclassified

“…Estas mediciones generan un gran volumen de datos que pueden ser usado por redes neuronales para mejorar los procesos de fabricación. Se han usado redes neuronales para monitorear y predecir el perfil de disolución de lotes de fármacos (41). También se ha implementado la inteligencia artificial para monitorear otros procesos de fabricación, como la liofilización (42).…”

Section: Descubrimiento De Compuestos Farmacéuticosunclassified

Aplicaciones de la inteligencia artificial en la farmacología básica y clínica

Matsingos

Urdaneta²,

Hernández³

et al. 2022

Med.

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El descubrimiento y desarrollo de fármacos es un proceso complicado y arduo que implica un gran esfuerzo interdisciplinar. A grandes rasgos, el proceso puede dividirse en dos partes: la preclínica y la clínica, que juntas pueden durar hasta 12 años y costar entre 2 y 3 billones de dólares. Debido a la compleja naturaleza de la creación de nuevos medicamentos, que implica consideraciones bioquímicas y fisicoquímicas, así como consideraciones de seguridad y eficacia clínica, el proceso de descubrimiento de fármacos se caracteriza por una alta tasa de fracasos. En la era de la información, este proceso de desarrollo suele estar asociado a la generación de grandes cantidades de datos. La inteligencia artificial ha permitido aprovechar estos datos para acelerar el proceso de descubrimiento de fármacos y evitar posibles escollos que puedan llevar al fracaso de la comercialización de un medicamento. En esta revisión analizamos los nuevos avances en inteligencia artificial y aprendizaje automático en diferentes partes del proceso de descubrimiento de fármacos, desde la síntesis química hasta la selección de candidatos para los ensayos clínicos. Se muestra que la inteligencia artificial se ha aplicado en todas las etapas del descubrimiento de fármacos y se ha utilizado en gran medida para revolucionar los métodos de investigación tradicionales. La inteligencia artificial no sólo se ha utilizado para facilitar y acelerar los procesos de descubrimiento, sino también para obtener conocimientos y detectar patrones que no se conocían antes. El uso de inteligencia artificial es indispensable para el futuro del descubrimiento de fármacos.

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“…Even though, because of their possible pharmaceutical application, the non-toxic nature of NZ and the ZHB-30 composite had been demonstrated through acute toxicity testing (Krajišnik et al, 2014), further in vitro investigations of drug dissolution from the IB-modified zeolite composites prepared were performed on the samples IB/ ZBC-20 and IB/ZCP-20 with smaller amounts of surfactant. The drug-release profiles from the IB/ ZBC-20 and IB/ZCP-20 composites are shown in Fig.…”

Section: In Vitro Drug-release Studiesmentioning

confidence: 99%

Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers

et al. 2015

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The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants – benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to ~40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.

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Application of Artificial Neural Networks in Prediction of Diclofenac Sodium Release From Drug-Modified Zeolites Physical Mixtures and Antiedematous Activity Assessment

Cited by 17 publications

References 31 publications

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite

Aplicaciones de la inteligencia artificial en la farmacología básica y clínica

Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers

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