Application of chitosan matrix for delivery of rutin

Arruda, Iza Natália Queiroz de; Pereira, Valdir Aniceto; Stefani, Ricardo

doi:10.1007/s13738-016-1004-x

Cited by 11 publications

(2 citation statements)

References 28 publications

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“…Furthermore, the low water solubility of RT should be considered [35]. To overcome these problems, different delivery systems for RT were studied [37], such as complexation with β-cyclodextrin [38] or phospholipids [39], encapsulation into polymeric nanoparticles [40,41], or nanoemulsions [42]. In this way, high anti-inflammatory, anti-cancer, and antioxidant activities were observed through different methods of administration [43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

et al. 2021

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This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a solid lipid and Polysorbate 80 as surfactant were used for the SLNs preparation, using the solvent emulsification/diffusion method. We obtained spherical RT-SLNs with low sizes, ranging from 40 to 60 nm (hydrodynamic radius) for the SLNs prepared starting from 2% and 5% (w/w) theoretical amount. All prepared formulations showed negative zeta-potential values. RT was efficiently encapsulated within SLNs, obtaining high encapsulation efficiency and drug content percentages, particularly for SLNs prepared with a 5% theoretical amount of RT. In vitro release profiles and analysis of the obtained data applying different kinetic models revealed Fickian diffusion as the main mechanism of RT release from the SLNs. The morphology of RT-SLNs was characterized by scanning electron microscopy (SEM), whereas the interactions between RT and the lipid matrix were investigated by Raman spectroscopy, evidencing spectral modifications of characteristic bands of RT due to the establishment of new interactions. Finally, antioxidant activity assay on human glioblastoma astrocytoma (U373) culture cells showed a dose-dependent activity for RT-SLNs, particularly at the highest assayed dose (50 μM), whereas the free drug showed the lesser activity.

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Section: Introductionmentioning

confidence: 99%

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

et al. 2021

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“…Much attention also has been given for the use of CH as polymer shell of the microcapsules and also as matrices, conform de Arruda et al these matrices present features that can be used in the delivery of bioactive compounds, for example. 5 As shell can be application on textile substrates. Textile fibers are mostly anionic and CH for being the only cationic polymer already has an ionic affinity.…”

Section: Introductionmentioning

confidence: 99%

Chitosan microcapsules: Methods of the production and use in the textile finishing

Valle¹,

Valle²,

Bierhalz³

et al. 2021

J of Applied Polymer Sci

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Biopolymeric chitosan is considered a promising encapsulating agent for textile applications due to its biocompatibility, lack of toxicity, antibacterial activity, high availability, and low cost. After cellulose, it is nature's most important organic compound. Also, chitosan has unique chemical properties due to its cationic charge in solution. Microencapsulation technologies play an important role in protecting the trapped material and in the durability of the effect, controlling the release rate. The application of chitosan microcapsules in textiles follows the current interest of industries in functionalization technologies that give different properties to products, such as aroma finish, insect repellency, antimicrobial activity, and thermal comfort. In this sense, methods of coacervation, ionic gelation, and LBL are presented for the production of chitosan-based microcapsules and methods of textile finishing that incorporate them are presented, bath exhaustion, filling, dry drying cure, spraying, immersion, and grafting chemical. Finally, current trends in the textile market are identified and guidance on future developments.

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Effects of nitrogen gas ratio on the structural and corrosion properties of ZrN thin films grown on biodegradable magnesium alloy by ion-beam sputtering

Kiahosseini

Larijani

2017

Appl. Phys. A

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Application of chitosan matrix for delivery of rutin

Cited by 11 publications

References 28 publications

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation

Chitosan microcapsules: Methods of the production and use in the textile finishing

Effects of nitrogen gas ratio on the structural and corrosion properties of ZrN thin films grown on biodegradable magnesium alloy by ion-beam sputtering

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