Application of LC–MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

“…The mass transition m/z 422 → 198 for mosapride confirmed several previous reports [15,22,23]. The fragmentation pathways have been described previously in several papers [15,22,26].…”

“…Pharmacokinetic profiles of mosapride in rats [19], dogs, monkeys [20], and healthy human subjects [21] have been well characterized by HPLC with UV detection. Recently, liquid chromatography-tandem mass spectrometry (LC/MS/MS) was introduced to detect a polar impurity in the bulk drugs of mosapride citrate [22]. LC/MS/MS was further applied to the determination of mosapride in human plasma [23].…”

Development and validation of a liquid chromatographic method for determination of related-substances of mosapride citrate in bulk drugs and pharmaceuticals

“…The effect of mobile phase pH and column temperature on the retention behavior of enantiomers of mosapride citrate using chiral-AGP was studied [13]. Recently, Kumar et al [14] have studied the application of LC-MS/MS for detection of a polar impurity in the bulk drugs of mosapride citrate. However, none of these methods address to the problem of separation and determination of all process related impurities, which are most likely to be present in the finished products of mosapride citrate.…”

Enantioselective determination of a gastroprokinetic drug using amylose tris-(3,5-dimethylphenylcarbamate) as a stationary phase by HPLC

“…Its pharmacokinetic profiles in rats, dogs, monkeys and in healthy subjects [16][17][18] have been well characterized. Kumar et al have studied the application of LC-MS/MS for detection of a polar impurity in the bulk drugs of MSP [19]. Recently, we have developed an achiral RP-HPLC method to determine the process-related impurities of MSP in bulk drugs and pharmaceuticals [20].…”