Application of magnetic microspheres in labelling and separation of cells

Preparation and cytotoxic properties of goethite‐based nanoparticles covered with decyldimethyl(dimethylaminoethoxy) silane methiodide

“…Fe 3+ ions are the most desirable in the formation of intracellular and macromolecular biologically active or MR contrast materials because of these ions' low toxicity and existence in nature in many tissues. [5] In this paper we present an investigation concerning the usage of goethite (α-FeOOH, iron oxyhydroxide)-based nanoparticles as carriers of biologically active compounds. This is reasonable because of its chemical structure allowing greater possibility for surface modification of the nanoparticles due to the presence of hydroxy groups and at the same time being stable due to the three-valency state of iron.…”

Magnetic transducers in biosensors and bioassays

“…Until now the most common uses for large superparamagnetic particles in biotechnology has been for the labelling and separation of cells and macromolecules. These particles have a size of several micrometers [24,25]. Today there are a number of established companies, such as Dynal and PerSeptive, which commercially offer this type of particles for separation purposes.…”

Geometrical optimization of microstripe arrays for microbead magnetophoresis

“…3 Magnetic beads in combination with magnetic forces have long been used for concentration and purification of biological targets. 4,5 This is most easily done by trapping the beads using a strong magnetic field gradient. 4,6,7 To obtain high throughput, magnetic forces have also been used to separate magnetic beads in a fluid flow.…”