Applications of breath gas analysis in medicine

Amann, Anton; Poupart, Guy; Telser, Stefan; Ledochowski, Maximilian; Schmid, Alex P.; Mechtcheriakov, Sergei

doi:10.1016/j.ijms.2004.08.010

Cited by 184 publications

(157 citation statements)

References 21 publications

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“…A summary of physiological origins of selected endogenous breath molecules is presented in Table 3. Factors affecting the great variability in the composition of human breath include physical condition, general health of the subject, food intake, environmental influences and overall lifestyle (Amann et al, 2004;Libardoni et al, 2006). (Wehinger et al, 2007), acetaldehyde , heptanal (Phillips et al, 1999a,b;Deng et al, 2004a,b;Phillips et al, 2006); hexanal (Phillips et al, 1999a,b;Deng et al, 2004a,b) Ketones 1-Phenylethanone (Phillips et al, 1999a,b) Hydrocarbons Benzene (Yu et al, 2005;Phillips et al, 1999a,b;Poli et al, 2005); toluene (Poli et al, 2005); styrene (Yu et al, 2005;Phillips et al, 1999a,b;Poli et al, 2005); xylenes isomers (Phillips et al, 1999a,b;Poli et al, 2005); trimethylbenzenes isomers (Phillips et al, 1999a,b;Poli et al, 2005); propylbenzene (Yu et al, 2005;Phillips et al, 1999a,b); ethylbenzene (Poli et al, 2005) 2-Methylheptane (Phillips et al, 1999a,b); 3-methylnonane (Phillips et al, 1999a,b); 3-methyloctane (Phillips et al, 1999a,b); 2-methylpentane (Poli et al, 2005); 2,2,4,6,6-pentamethylheptane (Phillips et al, 1999a,b;Poli et al, 2005); 2,4-dimethylheptane (Phillips et al, 1999a,b); pentane (Poli et al, 2005); heptane (Poli et al, 2005); octane (Poli et al, 2005); decane (Yu et al, 2005;Phillips et al, 1999a,b;Poli et al, 2005); undecane (Yu et al, 2005;Phillips et al, 1999a,b); methylcyclopentane …”

Section: Endogenous Volatile Markers and Their Clinical Applicationsmentioning

confidence: 99%

“…This method generally involves both sampling and preconcentration steps prior to the introduction of the collected sample into a gas chromatographic column, which can lead to contamination problems and losses of analytes. The measurements are not taken in situ, are not in real time and are time-consuming (Amann et al, 2004).…”

Section: Analysis and Detectionmentioning

confidence: 99%

“…Proton transfer reaction mass spectrometry (PTR-MS) has also been used for rapid and online measurements of breath VOCs measurement (Amann et al, 2004Janovsky et al, 2005). PTR-MS instruments consist of four parts: an ion source where H 3 O + ions are produced, a drift tube section, a transition chamber and an ion detection section containing a quadrupole mass spectrometer or a TOF mass spectrometer (Blake et al, 2004) and a secondary electron multiplier.…”

Section: Analysis and Detectionmentioning

confidence: 99%

“…In the drift tube, the trace gases from the sample gas are ionized by proton transfer reactions with H 3 O + primary ions. This reaction takes place when the proton affinity of (Amann et al, 2004). the trace compound is higher than that of water (E = 166.5 kcal/mol = 7.16 eV).…”

Section: Analysis and Detectionmentioning

confidence: 99%

“…These compounds do not interfere with the measurement because they do not react with H 3 O + ions (Ípan!l and Smith, 2001;Steeghs et al, 2006). Figure 8 shows the concentration-times series for ionic mass m/z = 69 (= m 1 + m H , tentatively identified as isoprene with molecular mass m 1 = 68 u) during one night (Amann et al, 2004, in comparison with the heart rate. Increasing heart rate leads to an increased blood flow and consequently to an increased concentration of exhaled isoprene (Karl et al, 2001) as long as no wash-out phenomenon occurs.…”

Section: Analysis and Detectionmentioning

confidence: 99%

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Human exhaled air analytics: biomarkers of diseases

Buszewski

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Ligor

et al. 2007

Biomedical Chromatography

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Section: Endogenous Volatile Markers and Their Clinical Applicationsmentioning

confidence: 99%

Section: Analysis and Detectionmentioning

confidence: 99%

Section: Analysis and Detectionmentioning

confidence: 99%

Section: Analysis and Detectionmentioning

confidence: 99%

Section: Analysis and Detectionmentioning

confidence: 99%

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Human exhaled air analytics: biomarkers of diseases

Buszewski

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et al. 2007

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show abstract

PTR‐MS in the Medical Sciences

Ellis

Mayhew

2013

Proton Transfer Reaction Mass Spectrometry

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Investigation of acetone, butanol and carbon dioxide as new breath biomarkers for convenient and noninvasive diagnosis of obstructive sleep apnea syndrome

Bayrakli

Öztürk

Akman

2016

Biomedical Chromatography

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The objective of the present study was to investigate whether analysis of carbon dioxide, acetone and/or butanol present in human breath can be used as a simple and noninvasive diagnosis method for obstructive sleep apnea syndrome (OSAS). For this purpose, overnight changes in the concentrations of these breath molecules were measured before and after sleep in 10 patients who underwent polysomnography and were diagnosed with OSAS, and were compared with the levels of these biomarkers determined after sleep in 10 healthy subjects. The concentrations of exhaled carbon dioxide were measured using external cavity laser-based off-axis cavity enhanced absorption spectroscopy, whereas the levels of exhaled acetone and butanol were determined using thermal desorption gas chromatography mass spectrometry. We observed no significant changes in the levels of exhaled acetone and carbon dioxide in OSAS patients after sleep compared with pre-sleep values and compared with those in healthy control subjects. However, for the first time, to our knowledge, analyses of expired air showed an increased concentration of butanol after sleep compared with that before sleep and compared with that in healthy subjects. These results suggest that butanol can be established as a potential biomarker to enable the convenient and noninvasive diagnosis of OSAS in the future.

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Applications of breath gas analysis in medicine

Cited by 184 publications

References 21 publications

Human exhaled air analytics: biomarkers of diseases

Human exhaled air analytics: biomarkers of diseases

PTR‐MS in the Medical Sciences

Investigation of acetone, butanol and carbon dioxide as new breath biomarkers for convenient and noninvasive diagnosis of obstructive sleep apnea syndrome

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