Applications of electrospun scaffolds with enlarged pores in tissue engineering

Zhang, Yuangeng; Zhang, Miaomiao; Cheng, Duanrui; Xu, Shixin; Du, Chen; Xie, Li; Zhao, Wen

doi:10.1039/d1bm01651b

Cited by 39 publications

(21 citation statements)

References 152 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 49 , 50 To this end, developing 3D architecture with ideal pore architecture is critical for cell behaviors and the formation of new tissues presenting efficient delivery of drugs, biological molecules as well as stem cells. 51 , 52 Therefore, pore size, porosity, the roughness of pore surfaces, and bioactivity of scaffolds play a critical role in regenerating tissues. In this study, highly porous scaffolds were fabricated using the phase separation method, and frozen solvent was conducive to the formation of the pore structures as described in our previous report.…”

Section: Discussionmentioning

confidence: 99%

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Guo¹,

Li²,

Wang³

et al. 2022

IJN

View full text Add to dashboard Cite

Introduction As a popular dietary supplement containing sulfur compound, methylsulfonylmethane (MSM) has been widely used as an alternative oral medicine to relieve joint pain, reduce inflammation and promote collagen protein synthesis. However, it is rarely used in developing bioactive scaffolds in bone tissue engineering. Methods Three-dimensional (3D) hydroxyapatite/poly (lactide- co -glycolide) (HA/PLGA) porous scaffolds with different doping levels of MSM were prepared using the phase separation method. MSM loading efficiency, in vitro drug release as well as the biological activity of MSM-loaded scaffolds were investigated by incubating mouse pre-osteoblasts (MC3T3-E1) in the uniform and interconnected porous scaffolds. Results Sustained release of MSM from the scaffolds was observed, and the total MSM release from 1% and 10% MSM/HA/PLGA scaffolds within 16 days was up to 64.9% and 68.2%, respectively. Cell viability, proliferation, and alkaline phosphatase (ALP) activity were significantly promoted by incorporating 0.1% of MSM in the scaffolds. In vivo bone formation ability was significantly enhanced for 1% MSM/HA/PLGA scaffolds indicated by the repair of rabbit radius defects which might be affected by a stimulated release of MSM by enzyme systems in vivo. Discussion Finding from this study revealed that the incorporation of MSM would be effective in improving the osteogenesis activity of the HA/PLGA porous scaffolds.

show abstract

Section: Discussionmentioning

confidence: 99%

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Guo¹,

Li²,

Wang³

et al. 2022

IJN

View full text Add to dashboard Cite

show abstract

“…In terms of energy storage, high porosity and large specific surface area are advantageous for maximizing the use of active sites during redox reactions and high-flux mass transfer [ 122 ]. In the field of biology, porous structures can improve drug release, further enhancing drug efficacy, and can improve cell adhesion and have a great deal of promise for vascular tissue engineering and regeneration [ 123 ]. Based on the developed electrospun porous nanofiber preparation process, researchers can take advantage of the characteristics of porous nanofibers in combination with other processes, such as fiber surface modification [ 124 , 125 ] or the addition of functional substances [ 126 , 127 , 128 ], which can have a significant impact in different fields.…”

Section: Applications Of Electrospun Porous Nanofibersmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

View full text Add to dashboard Cite

Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

show abstract

“…10,11 Research in biomaterials-based skin scaffolds is developing toward the direction of scarless wounds and the reconstruction of intact skin organs. [12][13][14] To achieve effective regenerative repair and functional recovery of damaged/diseased skin tissues, researchers must understand the anatomy of the skin. The skin is the outermost layer of the human body and the first line of defense, protecting the body from infection, water loss, and body temperature imbalance.…”

Section: Introductionmentioning

confidence: 99%

Designing biomimetic scaffolds for skin tissue engineering

et al. 2023

View full text Add to dashboard Cite

show abstract

Applications of electrospun scaffolds with enlarged pores in tissue engineering

Abstract: Despite electrospinning has multiple advantages over other methods such as creating materials with superfine fiber diameter, high specific surface area, and good mechanical properties, the pore diameter of scaffolds prepared...

Cited by 39 publications

References 152 publications

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Designing biomimetic scaffolds for skin tissue engineering

Contact Info

Product

Resources

About