Argyrophilic nuclear organizer regions in nasopharyngeal carcinoma and paraneoplastic epithelia

Abstract

The morphometric analysis of AgNORs reflected cell proliferative activity and histologic differentiation of tumor rather than malignant transformation in different nasopharyngeal epithelia and NPC. AgNOR area and AgNOR area-count ratio are the most valuable features for differential diagnosis of normal, preneoplastic, and cancer cells.

Comparison of The Means of Argyrophilic Nucleolar Organizer Region (mAgNOR) Pre- and Post-Therapy in Nasopharyngeal Carcinoma Patients at Wahidin Sudirohusodo General Hospital Makassar

“…As found in this study that the mean AgNOR pre-and posttherapy for the WHO type 3 were statistically different in significant level, therefore, in accordance to the research conducted in 70 patients with NPC paraffin specimens, findings the mean AgNOR for WHO type 3 was higher than those in WHO type 2, our result is proven to be reliably supported. (27) The weakness of this research is limited of time, so that only a few samples can be observed until chemoradiotherapy completion.…”

The Use of Flow Cytometric DNA Ploidy Analysis of Liver Biopsies in Liver Cirrhosis and Hepatocellular Carcinoma

“…Analysis of AgNOR counts showed a significant difference between tumor and residual liver tissues of HCC or normal liver (P < 0.001) and this is in agreement with several studies (Shemizu et al, 1995;Siddiqui et al, 1999;Politi et al, 2004). However, Chen et al (2003) revealed that AgNOR area and AgNOR area-count ratio are the most valuable features for differential diagnosis of normal, preneoplastic, and cancer cells. Spolidorio et al (2002) found that the morphometric results were statistically different for normal mucosa, dysplasia, and microinvasive oral carcinoma and they concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy.…”

Value of Silver Binding Nucleolar Organiser Regions (AgNOR) in Squamous Cell Carcinomas of Upper Aero-digestive Tract

“…Many studies have clearly brought out the usefulness of AgNOR in squamous cell carcinomas in this regard. [2][3][4] Thus studies have shown that AgNOR values can serve as a useful prognostic parameter and a marker for tumour progression in squamous cell carcinomas [3,4,10,11].…”