Aromatic DNA adducts in lymphocytes of humans working at high and low traffic density areas

Ke, Yang; Airoldi, Luisa; Pastorelli, Roberta; Restano, Jolanda; Guanci, Marco; Hemminki, Kari

doi:10.1016/0009-2797(96)03720-9

Cited by 27 publications

(10 citation statements)

References 27 publications

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“…Drivers who spent most of their working hours in central Copenhagen had a higher adduct level than suburban and semirural drivers. In contrast, no difference in DNA adduct level could be observed in street vendors in Milan, Italy, working in areas of high and low traffic density (30). However, the Italian study included both smokers and nonsmokers, and smoking is known to increase the adduct level (31).…”

Section: Discussionmentioning

confidence: 88%

Biomarkers for exposure to ambient air pollution--comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress.

Autrup

Daneshvar

Dragsted

et al. 1999

Environ Health Perspect

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Human exposure to genotoxic compounds present in ambient air has been sdied using selected biomarkers in nonsmoking Danish bus drivers and pol workers. A li n variadion in biomarker levels was observed. Significantly higher levels of bulky carcinogen-DNA adducts (75.42 adducts/108 nucleotides) and of 2-amino-apidic semialdehyde (AAS) in plasma proteins (56.7 pmollmg protein) were observed in bus drivers working in the central part of Copenhagen, Denmark In contrast, significantly higher levels of AAS in hemoglobin (55,8 pmollmg protn), malondialdeh in plasma (0.96 nol/m plasma) nd polycic aromatic hydrocarbon (PAH)-albumin adduct (3.38 finol/pg lbumin) were observed in the suburban group. The biomarker levels in postal workers were similar to the levels in suburban bus drivers. In the combined group of bus drivers and postal workers, negative corlations were observed between bulky carcinogen-DNA adduct and PAH-albumin levels (p -0.005), and between DNA adduct and .y-glutamyl semialdhyde (GGS)

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Section: Discussionmentioning

confidence: 88%

Biomarkers for exposure to ambient air pollution--comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress.

Autrup

Daneshvar

Dragsted

et al. 1999

Environ Health Perspect

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“…In studies by Nielsen et al, 32 Omland et al, 83 Schoket et al, 45 Van Schooten et al, 21 Yang et al, 88 and Ovrebo et al 43 none of these teams reported statistically significant differences, although some did observe a quantitatively higher DNA-adduct concentration among smokers than among nonsmokers. Only Van Schooten et al 21 observed an increase, and only among exposed workers.…”

Section: Adductsmentioning

confidence: 91%

Validity of Biomarkers in Environmental Health Studies: The Case of PAHs and Benzene

Dor¹,

Dab

Empereur‐Bissonnet

et al. 1999

Critical Reviews in Toxicology

114

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Exposure biomarkers, which have long been restricted to the framework of occupational hygiene, currently arouse increasing interest in the field of environmental pollution. To assess their validity, we propose here a conceptual framework that is based on their intrinsic characteristics and on properties related to the procedures for their analysis. The most important criteria are specificity for the toxic substance under consideration and sensitivity, that is, the ability to distinguish contrasted levels of exposure. Their analytic sensitivity and specificity are also important. Fulfilling these criteria is especially important in the context of environmental pollution, because the levels of exposure, and thus the contrasts, are low. This framework is used to assess the validity of some biomarkers for polycyclic aromatic hydrocarbons (1-hydroxypyrene and DNA adducts) and for benzene (urinary and serum benzene, trans,trans muconic acid, and S-phenylmercapturic acid). This evaluation shows that the most relevant biomarkers for estimating individual exposure to environmental pollution are 1-hydroxypyrene for polycyclic aromatic hydrocarbons and urinary benzene and S-phenylmercapturic for benzene.

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“…When a surrogate tissue (white blood cells) was used, different results were observed from various laboratories. Some studies indicated a correlation between adduct levels in blood cells and lung as well as higher DNA adducts in smokers than in non smokers [ 26 – 28 ], while others demonstrate that white blood cells are not a good surrogate tissue [ 29 , 30 ] and still others that similar DNA adduct levels occur in blood cells from smokers and non-smokers [ 31 , 32 ], using 8-hydroxydeoxyguanosine as a marker of oxidative DNA damage [ 25 , 33 ]. With the same method other authors [ 34 , 35 ] report a significant increase in oxidative DNA damage in leukocytes from subjects exposed to environmental tobacco smoke and a correlation between DNA damage and tobacco exposure, measured by plasma cotinine levels.…”

Section: Biomarkers Of Active and Passive Smoke Exposurementioning

confidence: 99%

Biomarkers of Induced Active and Passive Smoking Damage

Lodovici

Bigagli

2009

IJERPH

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Abstract:In addition to the well-known link between smoking and lung cancer, large epidemiological studies have shown a relationship between smoking and cancers of the nose, oral cavity, oropharynx, larynx, esophagus, pancreas, bladder, kidney, stomach, liver, colon and cervix, as well as myeloid leukemia. Epidemiological evidence has reported a direct link between exposure of non-smokers to environmental tobacco smoke and disease, most notably, lung cancer. Much evidence demonstrates that carcinogenic-DNA adducts are useful markers of tobacco smoke exposure, providing an integrated measurement of carcinogen intake, metabolic activation, and delivery to the DNA in target tissues. Monitoring accessible surrogate tissues, such as white blood cells or bronchoalveolar lavage (BAL) cells, also provides a means of investigating passive and active tobacco exposure in healthy individuals and cancer patients. Levels of DNA adducts measured in many tissues of smokers are significantly higher than in non-smokers. While some studies have demonstrated an association between carcinogenic DNA adducts and cancer in current smokers, no association has been observed in ex or never smokers. The role of genetic susceptibility in the development of smoking related-cancer is essential. In order to establish whether smoking-related DNA adducts are biomarkers of tobacco smoke exposure and/or its carcinogenic activity we summarized all data that associated tobacco smoke exposure and smoking-related DNA adducts both in controls and/or in cancer cases and studies where the effect of genetic polymorphisms involved in the activation and deactivation of carcinogens were also evaluated. In the future we hope we will be able to screen for lung cancer susceptibility by using specific biomarkers and that subjects of compared groups can be stratified for multiple potential modulators of biomarkers, taking into account various confounding factors.

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Aromatic DNA adducts in lymphocytes of humans working at high and low traffic density areas

Cited by 27 publications

References 27 publications

Biomarkers for exposure to ambient air pollution--comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress.

Biomarkers for exposure to ambient air pollution--comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress.

Validity of Biomarkers in Environmental Health Studies: The Case of PAHs and Benzene

Biomarkers of Induced Active and Passive Smoking Damage

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