Assessment of Cocaethylene Lethality in Long–Evans Female and Male Rats

Sobel, B.-F. X.; Hutchinson, A. C. W.; Diamond, Hilary F.; Etkind, Susan A; Ziervogel, S.D.; Ferrari, Carolyn M.; Riley, Anthony L.

doi:10.1016/s0892-0362(97)00132-3

Cited by 4 publications

(1 citation statement)

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“…Female rats also appear to be more sensitive than males to the behavioral activating effects of amphetamine (Becker, 1990, 1999; Forgie & Stewart, 1994), alcohol (Almeida, Shoaib, Deicke, Fischer, Darwish, & Patchev, 1998), cocaethylene (Sobel et al, 1998), cocaine (Sell, Scalzitti, Thomas, & Cunningham, 2000), and pentobarbital (Suzuki, Koike, Yoshi, & Yanaura, 1985), and recent evidence indicates that some of these sensitization effects may be estrogen dependent (Sell et al, 2000). The present results indicate greater sensitivity in females to the suppressant effects of ketoconazole, but only when behavior is elevated by food restriction.…”

Section: Discussionmentioning

confidence: 99%

Ketoconazole suppresses food restriction–induced increases in heroin self-administration in rats: Sex differences.

Carroll¹,

Campbell²,

Heideman³

2001

Experimental and Clinical Psychopharmacology

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The effects of ketoconazole, an inhibitor of corticosterone synthesis, were examined during food satiation and food restriction in male and female rats to determine whether increases in heroin self-administration prompted by food restriction were due to a stress response. Females self-administered more heroin infusions than males under both feeding conditions. Food restriction increased heroin infusions by an average of 96% for both females and males. Ketoconazole suppressed the increase due to food restriction in females but not in males. Corticosterone reversed the effect of ketoconazole in a group of 8 females, suggesting an interaction between feeding conditions, sex, and the stress response in rats.

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