Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11 → q21 segment of chromosome 6

Harbitz, I.; Chowdhary, Bhanu P.; Thomsen, Preben D.; Davies, William A.; Kaufmann, Uwe; Kran, Sissel; Gustavsson, I.; Christensen, K.; Hauge, Jens G.

doi:10.1016/0888-7543(90)90278-3

Cited by 84 publications

(35 citation statements)

References 23 publications

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“…The exact order of HAL and the marker loci was found to be S, HAL, PHI, H, PO-2 and PGD . Additionally, Harbitz et al (1990) placed the Ca^"" release channel gene, a candidate gene for the PSS, on the long arm of chromosome 6.…”

Section: Chromosomal Locationmentioning

confidence: 99%

Effects of porcine stress syndrome genotype on maternal traits in swine

Stalder

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Section: Chromosomal Locationmentioning

confidence: 99%

Effects of porcine stress syndrome genotype on maternal traits in swine

Stalder

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“…Since the RYR1 gene has been physically mapped to Chr 6 (6pl 1-> q21); Davies et al 1988;Harbitz et al 1990), this chromosome is a good candidate for the use of a directed cloning approach. We report here the production of Chr 6 libraries with flow-sorted Chr 6 material and the detection of 15 new microsatellites markers from these libraries.…”

Section: Introductionmentioning

confidence: 99%

Mapping of microsatellite markers developed from a flow-sorted swine chromosome 6 library

et al. 1997

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“…In pigs, MH has been associated with a recessive mutation in the gene coding for the porcine calcium release channel, also called the ryanodine receptor gene (ryr-1 locus) or halothane gene (Hal) (Fujii et al, 1991), which is located on chromosome 6 (Harbitz et al, 1990). The primary defect resides in a single point mutation (Arg614Cys) in the porcine RYR1 protein.…”

mentioning

confidence: 99%

Frequency of the malignant hyperthermia gene in the South African pig industry

Soma¹,

Marle-Köster²,

Frylinck³

2015

SA J. An. Sci.

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Porcine stress syndrome (PSS) is a genetic disorder caused by a recessive mutation in the halothane (HAL) gene and results in sudden death of pigs when placed under stress during transport and preslaughtering conditions. Animals that are affected by this mutation tend to develop pale, soft and exudative (PSE) meat, which results in an economic loss. In South Africa, the frequency of the number of carriers (Nn) and recessive (nn) pigs has increased by 21% to 30% from 2000 to 2003. This study aims to determine the prevalence of the malignant hyperthermia (MH) gene in breeding boars at nucleus or seed-stock level, and the prevalence at commercial abattoirs across the South African pig industry. Results indicate a low number of carriers (Nn = 17) and recessive (nn = 1) pigs at seed-stock level. For commercial abattoirs, 96.4% of the pigs tested did not carry the mutation. The low incidence of the MH mutation from breeding stock should eliminate a contributory factor to PSE meat in South Africa. Transport over long distances to abattoirs may ultimately have an effect on pork obtained even from non-carriers of the MH mutation. ______________________________________________________________________________________

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Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11 → q21 segment of chromosome 6

Cited by 84 publications

References 23 publications

Effects of porcine stress syndrome genotype on maternal traits in swine

Effects of porcine stress syndrome genotype on maternal traits in swine

Mapping of microsatellite markers developed from a flow-sorted swine chromosome 6 library

Frequency of the malignant hyperthermia gene in the South African pig industry

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