Association between gastroesophageal reflux disease and depression disorder

Liu, Yu; Zhou, Panpan; Zhang, Shixiong; Wu, Huiqing; Yang, Zeqi; Xu, Miaochan; Liu, Shaowei; Wang, Yangang

doi:10.1097/md.0000000000022696

Cited by 2 publications

(2 citation statements)

References 22 publications

(15 reference statements)

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“…In addition, the symptoms of GERD also increase the risk of psychological disorders, including depression [ 44 ]. The meta-analysis also demonstrated the relationship between depression and gastroesophageal reflux disease [ 45 , 46 ]. Otherwise, These findings imply that due consideration should be given to the preventive measures and diagnostic approaches for the other ailment in the presence of either MD or GERD.…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization study of gastroesophageal reflux disease and major depression

Zheng,

Zhou,

Tong

et al. 2023

PLoS ONE

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This study systematically investigated the causal relationship between gastroesophageal reflux disease (GERD) and major depression (MD). Single-nucleotide polymorphisms (SNPs) associated with disorders of interest were screened via the genome-wide association study (GWAS) enrolling individuals of European descent. Summary-level data for GERD and MD were extracted from the UK Biobank. The inverse-variance-weighted (IVW) method was utilized as the primary analysis. Sensitivity analyses were performed using the MR-Egger method, the Maximum likelihood method, the MR-pleiotropy residual sum outlier (MR-PRESSO) method, and MR-robust adjusted profile score (MR-RAPS) method. MR-Egger regression, heterogeneity tests, pleiotropy tests, and leave-one-out tests were also performed to analyze sensitivity. The MR Steiger test was used to verify the directionality of the exposure to the outcome. An available website tool (https://shiny.cnsgenomics.com/mRnd/) was used to calculate the statistical power of MR analysis. Meta-analysis was applied to test MD’s average genetically predicted effect on GERD. Our MR study showed a bidirectional causal association between MD and GERD. Regarding MD to GERD, there was a positive association between them; the ORs were 1.500 (95% CI = 1.320–1.704; P = 4.91E-10) and 2.058 (95% CI = 1.868–2.267; P = 2.20E-48) in the IVW method, respectively. In addition, the meta-analysis also showed a strong positive causal association between MD and GERD. When exposure and outcome were reversed, genetic predisposition to GERD was significantly associated with the overall Risk of advanced MD (ieu-a-1187, OR = 1.982, 95% CI = 1.694–2.319, P = 1.41E-17; ieu-b-102, OR = 1.612, 95% CI = 1.530–2.700, P = 1.15E-70). Our study provides 100% power to detect the causal effect of MD on GERD and vice versa. Genetically predicted MD was positively associated with higher GERD risk, and vice versa. Our study reminds clinicians to pay attention to screening for GERD when diagnosing and treating MD and vice versa. Moreover, there may be positive feedback between MD and GERD when treating and preventing one disorder may benefit the treatment and prevention of the other.

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Section: Discussionmentioning

confidence: 99%

Mendelian randomization study of gastroesophageal reflux disease and major depression

Zheng,

Zhou,

Tong

et al. 2023

PLoS ONE

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“…Gastroesophageal reflux disease (GERD) is a disease that presents with troubling symptoms and complications due to stomach reflux into the esophagus. In developing countries, GERD is one of the most prevalent gastrointestinal disorders [1]. GERD plays a pivotal role in the health-associated quality of life (QOL) by causing difficulties in daily social activities and also in the emotional and physical well-being of the affected patients.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population?

Paul¹,

Abbas²,

Nassar³

et al. 2022

Cureus

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Gastroesophageal reflux disease (GERD) is a condition characterized by the reflux of stomach contents into the esophagus which leads to heartburn and regurgitation. GERD has been categorized its types according to severity. The categories that have been discussed in this study are reflux esophagitis (RE), non-erosive reflux disease (NERD), and Barrett's esophagus. Our study compared various studies and showed that the subjects with GERD had a high level of anxiety and depression. Gastroesophageal reflux disease has a significant negative impact on the quality of life (QoL) by perturbing daily activities. The majority of GERD patients use antacid drugs to control their acid symptoms. However, these symptoms are sometimes difficult to control, even with the most potent proton-pump inhibitors (PPIs) and these patients tend to have a lower response rate. According to the clinical data, Anxiety, and Depression are linked to the development of GERD. A major focus of this study is to explore psychological influences such as anxiety and depression, and how they relate to GERD. This study also reviews the effect of these conditions on the younger population. It is concluded that the QoL of subjects with GERD is reduced by depression and anxiety.

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Association between gastroesophageal reflux disease and depression disorder

Cited by 2 publications

References 22 publications

Mendelian randomization study of gastroesophageal reflux disease and major depression

Mendelian randomization study of gastroesophageal reflux disease and major depression

Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population?

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