Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population

Abstract

Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in the elimination of tumor cells in the human body. We recruited 357 patients with non-small cell lung cancer (NSCLC) and 414 controls to evaluate the correlation between two genetic variations (IL18-607C/A and IL18-137G/C) and the pathogenesis of NSCLC. We used polymerase chain reaction-restriction fragment length polymorphism to genotype IL18-607C/A and IL18-137G/C. Statistical analysis revealed that individuals harboring the AA genotype of IL18-607C/A had an increased risk of NSCLC compared to those harboring the CC genotype (OR = 2.20, 95%CI = 1.30-3.74). Individuals expressing the A allele of IL18-607C/A had an elevated risk of developing NSCLC compared to those expressing the C allele (OR = 1.31, 95%CI = 1.06-1.62). In summary, our analysis shows that the IL18-607C/A genetic variation is related to the risk of NSCLC, whereas the IL18-137G/C variation is not. Therefore, the IL18-607C/A variation is related to the pathogenesis of NSCLC in the Chinese population studied.

Genetic Polymorphism of Cytokines as a Predictor of Phenotypic Development of Chronic Pain Syndrome in Cancer Patients

“…(5,28,29) SNPs of the following genes are reported to be associated with the burden of pain and with the development of depression and fatigue in patients with lung malignancy NOS3 (1474 T>A, rs1800783), IL1B (allele 31C, rs1143627), TNFR2 (Met196Arg, rs1061622), PTGS2 (837T>C, rs5275), IL10RB (Lys47Glu, rs2834167) (30) against the background of existing non-genetic factors (the patient's sex, the stage of cancer). (31,32) SNP 174G>C (rs1800795) of the promoter of the IL-6 gene is associated with alterations in the serum level of the cognominal cytokine IL-6. Homozygous carriers of the GG genotype have a higher level of IL-6 expression in comparison with homozygous carriers of the CC genotype.…”

“…The risk of non-small cell lung cancer in the Chinese population (32) The risk of pancreatic cancer (50) IL4 IL-4R 590 C>T (rs2243250) rs2243228 rs2227284 rs2070874…”

The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer

“…IL-18 is involved in the carcinogenesis of multiple cancers. Accumulating evidence indicated that the IL-18 promoter genotype was correlated with the risk of PC, nasopharyngeal carcinoma (NPC), HCC and NSCLC [182,183,184,185]. Moreover, genetic polymorphisms of IL-18 were linked with the prognosis and survival of patients with acute myeloid leukemia (AML) [186].…”

Cytokine Gene Polymorphisms as Predictors of Chronic Pain Syndrome in Oncology

“…С тяжелым бременем развития боли, депрес-сии и усталости у пациентов с ЗНО легких свя-заны ОНП следующих генов: ENOS (1474 T>A, rs1800783), IL1BT (аллель 31C, rs1143627), TNFR2 (Met196Arg, rs1061622), PTGS2 (837T>C, rs5275), IL10RB (Lys47Glu, rs2834167) [30] на фоне имею-щихся не генетических факторов (пол пациента, стадия ЗНО) [31,32].…”