Association between selected trace elements and body mass index and waist circumference: A cross sectional study

Zohal, Mohammad Ali; Jam-Ashkezari, Saeedeh; Namiranian, Nasim; Moosavi, Amin; Ghadiri‐Anari, Akram

doi:10.1016/j.dsx.2019.01.019

Cited by 16 publications

(22 citation statements)

References 32 publications

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“…This discrepancy may be driven by the small sample size in the study by Zaky et al [74] (24 obese individuals and 14 healthy controls) compared to the current study (437 participants). The current study also showed a tendency for increased WC with increased Zn tertiles while a previous study reported low serum Zn levels in the high WC group [75]. This study did not find a significant association between CMR factors and Zn levels in the multivariable adjusted model.…”

Section: Discussioncontrasting

confidence: 68%

“…This study did not find a significant association between CMR factors and Zn levels in the multivariable adjusted model. Differences are possibly a reflection of the small sample size in this previous report [ 75 ]. Previous animal studies have suggested that low serum Zn levels increases cholesterol concentration by increasing the production of phospholipids [ 76 ] because Zn has an essential role in expressing lipid metabolism-related regulatory enzymes [ 77 ].…”

Section: Discussionmentioning

confidence: 72%

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The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

et al. 2021

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Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between trace minerals and CMR were estimated by logistic regression. Partial correlation was performed to test the strength of the associations. Zn was not strongly correlated (p-value ˃ 0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p ˂ 0.001), pulse rate (PR) (0.18; p ˂ 0.001), total cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p ˂ 0.001); and negatively with diastolic blood pressure (DBP) (−0.13; p = 0.01). High plasma Cu significantly decreased the risk of metabolic syndrome (MetS) (0.121; p ˂ 0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p ˂ 0.01), and DBP (0.14; p ˂ 0.01); and negatively with BMI (−0.19; p ˂ 0.001), PR (−0.17; p ˂ 0.001), and HDL (−0.27; p ˂ 0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p ˂ 0.001) and MetS (5.570; p ˂ 0.01). These findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 72%

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

et al. 2021

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“…Several non-communicable diseases have been associated with alterations in the levels of some minerals, among them low magnesium levels. Evidence has suggested that magnesium depletion may play an essential role in the pathophysiology of diabetes mellitus, hypertension, obesity, and dyslipidemia (6,(11)(12)(13). In this context, there is a biological plausibility to associate hypomagnesemia with metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Serum magnesium levels in relation to metabolic syndrome: A national population-based cross-sectional study from Jordan

Addin¹,

Batieha²,

Khader³

et al. 2021

Preprint

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Background/Aims: Individuals with metabolic syndrome are at higher risk to develop cardiovascular disease, diabetes type 2, and certain types of cancers such as pancreatic, liver, and colorectal cancers. Studies suggest a potential association between hypomagnesemia and metabolic syndrome with conflicting results. The present study aims to estimate the prevalence of metabolic syndrome and its components in Jordan and to further explore the association between low magnesium levels and metabolic syndrome and its components. Methods Data were derived from the national population-based household survey conducted in Jordan in 2009. The study was multipurpose and collected a wide array of data including interview data, anthropometric measurements, and laboratory data. The present report deals, exclusively, with subjects aged ≥ 20 years. There was a total of 4,520 subjects (1113 men and 3407 women). Results We found alarmingly high prevalence rates of metabolic syndrome and its components defined by IDF (international diabetic federation) criteria (39.8%) with the highest burden being among women (40.7% in women and 37.4% in men). Among metabolic syndrome components, central obesity and low HDL were the most commonly occurring components of metabolic syndrome (62.6% and 65.5%, respectively). We observed a significant inverse association between serum magnesium levels and metabolic syndrome after adjusting for age (OR = 1.57, p value = 0.048). Among metabolic syndrome components, low serum magnesium levels were significantly associated with low serum HDL levels (OR = 2.15, p value = 0.001). Conclusion Metabolic syndrome prevalence in Jordan is considerably high. Our findings suggest that serum magnesium levels are inversely associated with metabolic syndrome.

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“…In addition to Ca, phosphorus is also essential for bone tissue -together they form hydroxyapatite (Itkonen et al, 2017). Furthermore, plasma levels of P inversely correlate with body weight (Zohal et al, 2019).…”

Section: Introductionmentioning

confidence: 98%

“…It affects the action of insulin and is an integral part of many antioxidant enzymes. Its deficiency damages the synthesis of these enzymes, which increases oxidative stress (Zohal et al, 2019). A high incidence of Zn in the brain (amygdala, hippocampus, neocortex) has been observed and found to have several important effects on the CNS.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the intake of selected minerals in population of premenopausal women based on specific socio-demographic indicators

Jančichová

Habánová

Mrázová

et al. 2020

Potr. S. J. F. Sci.

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Eating behavior interventions are a modifiable risk factor for chronic diseases. The aim of this study was to monitor the intake of selected minerals – calcium, phosphorus, zinc, copper, selenium, and chromium in the diet of premenopausal women (n = 30) and to highlight the possible adverse effects of disbalanced intake of these elements. At the same time, we investigated whether socio-demographic factors and choice of food store have an impact on the intake of these substances. We assessed the intake of selected minerals using three-day nutritional protocols and subsequently processed the data. The participants were women between 40 and 50 years old, from districts of Partizánske and Prievidza, for whom menopause has not yet begun. Women provided information about their place of residence (urban or rural area), type of home they live in (family house or apartment), and the type of food store where they grocery shop. The results indicate an impact of the place of residence: higher intake of zinc (p = 0.012) and selenium (p = 0.020) were observed in the participants from the urban area. The impact of the type of home was proven on the intake of chromium (p = 0.049), copper (p = 0.048), and carbohydrates (p = 0.021) with higher intake in the apartment-dwelling group. The impact of food store choice has not been confirmed. Based on the observed values, we conclude that the observed population might be at a higher risk of skeletal disorders and osteoporosis due to deficient calcium intake and the unfavorable ratio of Ca:P; increased Zn and Se intake levels may stimulate the development of cardiovascular risk factors and may also elevate the risk for type 2 diabetes mellitus.

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Association between selected trace elements and body mass index and waist circumference: A cross sectional study

Cited by 16 publications

References 32 publications

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

Serum magnesium levels in relation to metabolic syndrome: A national population-based cross-sectional study from Jordan

Assessment of the intake of selected minerals in population of premenopausal women based on specific socio-demographic indicators

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