Association of adverse outcomes of intrahepatic cholestasis of pregnancy with zonulin levels

Deniz, Çiğdem; Özler, Sibel; Sayın, Fatma Kübra

doi:10.1080/01443615.2020.1820463

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Previous studies have revealed that intrahepatic cholestasis of pregnancy has consistently been associated with an increased incidence of adverse perinatal outcomes, including spontaneous preterm delivery, non-reassuring fetal status, meconium staining of the amniotic fluid, and stillbirth [3,6,33]. However, there has been much debate in the literature regarding the precise nature of the risk to the fetus and the true incidence of these outcomes [32,34]. The results of our study showed that although the incidence of MSAF does vary significantly, there was no significant difference in the incidence of neonatal asphyxia among the mothers without intrahepatic cholestasis of pregnancy, with mild and severe intrahepatic cholestasis of pregnancy groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

Huang

Liu

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Discussionmentioning

confidence: 99%

Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

Huang

Liu

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Deniz et al were the first to reveal the association between zonulin and ICP in the literature [ 23 ]. They evaluated the plasma zonulin levels and perinatal outcomes of 44 pregnant women with ICP and 44 controls.…”

Section: Discussionmentioning

confidence: 99%

“…The dissociation of tight junctions by zonulin through epidermal growth factor receptor activation increases intestinal permeability [ 25 ]. Systemic low-grade inflammation triggered by zonulin leads not only to chronic inflammatory diseases, such as multiple sclerosis, celiac disease, and ankylosis spondylitis, but also to GDM and ICP [ 23 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…The study evaluated only the serum zonulin concentrations, but not the fecal zonulin levels. Most of published studies examined only the zonulin concentrations [ 20 , 22 , 23 ] in plasmatic samples; thus, the authors compared results with these studies. Furthermore, because BMI is not an adjustable and changeable parameter, it constitutes a confounding factor.…”

Section: Discussionmentioning

confidence: 99%

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How Do Serum Zonulin Levels Change in Gestational Diabetes Mellitus, Pregnancy Cholestasis, and the Coexistence of Both Diseases?

Güvey¹,

Çelik

Çalışkan

et al. 2021

IJERPH

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We investigated the question of how serum zonulin levels change in intrahepatic cholestasis of pregnancy (ICP) and gestational diabetes mellitus (GDM) and, in the case of the coexistence of ICP and GDM, evaluated the eventual increase in zonulin plasmatic levels. Participants were enrolled for the study between 25 February 2021 and 20 August 2021. The prospective case-control study included: group 1 of 95 pregnant women diagnosed with ICP; group 2 of 110 pregnant women diagnosed with GDM; group 3 of 16 women diagnosed with both GDM and ICP; group 4 of 136 healthy pregnant women as the control group. The groups were compared in terms of age, body mass index (BMI), gravidity, parity, gestational week of delivery, plasma zonulin levels, delivery type, birth weight, first- and fifth-minute APGAR scores, newborn intensive care unit (NICU) admission, and meconium staining of amniotic fluid parameters. The results suggested that the plasma zonulin levels of ICP (group 1), GDM (group 2), and GDM with ICP (group 3) patients were higher than those of the healthy pregnant women of group 4 (p < 0.001). Among the patient groups, the highest median plasma zonulin levels were found in group 3 (110.33 ng/mL). Zonulin levels were also associated with the severity of ICP and adverse pregnancy outcomes. High serum zonulin levels were related to GDM, ICP, and adverse perinatal outcomes. The coexistence of GDM and ICP led to higher serum zonulin concentrations.

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“…There is substantial evidence linking ICP to an increased risk of negative pregnancy outcomes such as preterm delivery (both spontaneous and induced), foetal distress, amniotic fluid meconium staining, and stillbirth (Fu and Xu, 2021). Pregnancy problems are more likely in women with more severe cholestasis because of an increase in maternal serum bile acid levels (Deniz et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review On Complications of Intrahepatic Cholestasis of Pregnancy

Chaudhary¹,

Anjum²,

Khan³

et al. 2022

PJMHS

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A potentially dangerous liver condition called intrahepatic cholestasis of pregnancy (ICP) can appear during pregnancy. Primarily manifesting in the third trimester, characteristic symptoms include pruritus (itching) of the soles and palms, elevated blood bile acid levels, and impaired liver function. Several medications have been demonstrated to significantly improve biochemical indicators and gestational age of birth in patients with ICP, and they also alleviate the pruritus experienced by the mother. The use of these drugs during pregnancy may have serious consequences. This systematic review aims to describe maternal and foetal outcomes related to ICP and identify major biochemical and clinical predictors of foetal problems in women diagnosed with ICP. To provide context for the current investigation, Google Scholar and PubMed were searched for articles published between 2012 and 2022. References and bibliographies were employed in manual searches in addition to internet resources. Critical Appraisal Skills Program (CASP) evaluated all selected research papers. Findings were presented using descriptive summary table besides critical analysis. Risks of adverse perinatal outcomes, such as stillbirth and early delivery, were associated with twin pregnancies with ICP. But, premature delivery and neonatal hypoxia are more common in IVF-created twin pregnancies than in naturally conceived twin births. Severe ICP effects are linked with higher risks of stillbirth, admission to a neonatal intensive care unit, and preterm delivery. Some perinatal issues are associated with a mother's serum bile acid levels rising during pregnancy. Congenital disabilities, premature birth, and postpartum bleeding are all associated with ICP. Extreme instances of ICP frequently result in the abrupt and unexpected death of the fetus inside the uterus. ICP and stillbirth develop early in twin pregnancies. Therefore, delivering at 37 weeks may not be desirable. Enhancing fetal prognosis, particularly in twin pregnancies generated through IVF, requires early and correct diagnosis and proper medical intervention. To reduce the likelihood of an indicated preterm delivery, the decision to terminate a pregnancy in pregnancies created through IVF should be made carefully. Despite the fact that there was a clear link between ICP and preeclampsia and GDM, ICP did not raise the risk of stillbirth. Bile acid levels between the mother and fetus correlate, suggesting a causative link between BA levels, prenatal problems, and bad outcomes. Keywords: Intrahepatic cholestasis of pregnancy; pregnancy outcomes; gynecology; women health

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Association of adverse outcomes of intrahepatic cholestasis of pregnancy with zonulin levels

Cited by 6 publications

References 37 publications

Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

How Do Serum Zonulin Levels Change in Gestational Diabetes Mellitus, Pregnancy Cholestasis, and the Coexistence of Both Diseases?

A Systematic Review On Complications of Intrahepatic Cholestasis of Pregnancy

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