Association of galactose and insulin resistance in polycystic ovary syndrome: A case-control study

Na, Zhijing; Jiang, Hongsheng; Meng, Yaxin; Song, Jiahui; Feng, Di; Fang, Yuanyuan; Shi, Bei; Li, Da

doi:10.1016/j.eclinm.2022.101379

Cited by 4 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another pathway revealed by the analysis of the most enriched and impacted metabolic mechanisms was galactose metabolism. Higher galactose levels have been correlated with IR in patients with polycystic ovary syndrome . In the d -galactose-induced aging model, a higher concentration of galactose leads to cardiac dysfunction .…”

Section: Discussionmentioning

confidence: 99%

“…Higher galactose levels have been correlated with IR in patients with polycystic ovary syndrome. 38 In the D-galactoseinduced aging model, a higher concentration of galactose leads to cardiac dysfunction. 39 In the present study also, galactose metabolic pathways were positively associated with IR in the HFD-induced mice model, validating the role of galactose metabolism in IR development.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct Metabolomic Profiling of Serum Samples from High-Fat-Diet-Induced Insulin-Resistant Mice

Tomar

Sharma

Araniti

et al. 2023

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

High-fat-diet (HFD)-induced obesity is associated with an elevated risk of insulin resistance (IR), which may precede the onset of type 2 diabetes mellitus and associated metabolic complications. Being a heterogeneous metabolic condition, it is pertinent to understand the metabolites and metabolic pathways that are altered during the development and progression of IR toward T2DM. Serum samples were collected from C57BL/6J mice fed with HFD or chow diet (CD) for 16 weeks. Collected samples were analyzed by gas chromatography−tandem mass spectrometry (GC−MS/MS). Data on the identified raw metabolites were evaluated using a combination of univariate and multivariate statistical methods. Mice fed with HFD had glucose and insulin intolerance associated with impairment of insulin signaling in key metabolic tissues. From the GC−MS/MS analysis of serum samples, a total of 75 common annotated metabolites were identified between HFD-and CD-fed mice. In the t-test, 22 significantly altered metabolites were identified. Out of these, 16 metabolites were up-accumulated, whereas 6 metabolites were down-accumulated. Pathway analysis identified 4 significantly altered metabolic pathways. In particular, primary bile acid biosynthesis and linoleic acid metabolism were upregulated, whereas the TCA cycle and pentose and glucuronate interconversion were downregulated in HFD-fed mice in comparison to CD-fed mice. These results show the distinct metabolic profiles associated with the onset of IR that could provide promising metabolic biomarkers for diagnostic and clinical applications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinct Metabolomic Profiling of Serum Samples from High-Fat-Diet-Induced Insulin-Resistant Mice

Tomar

Sharma

Araniti

et al. 2023

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

show abstract

“…4.1 mmol/l; and HDL-C < 1.0 mmol/l, fulfilling at least one of the above criteria (Table S3). 15 According to the criteria proposed by the American Association of Clinical Endocrinologists/American College of Endocrinology, the manifestation of three or more of the following factors is sufficient for the diagnosis of metabolic syndrome 16 :BMI [?] 25 kg/m 2 ; TG [?]…”

Section: Subgroups Of Participantsmentioning

confidence: 99%

Fructose-associated elevation of serum uric acid levels may be involved in metabolic disorders in polycystic ovary syndrome: A case-control study

Feng

Song

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Objective To investigate the relationship between serum fructose and uric acid levels in patients with polycystic ovary syndrome (PCOS). Design A case-control study. Setting University-affiliated in vitro fertilization clinic. Population 292 patients with PCOS and 482 controls. Main Outcome Measures Serum fructose, uric acid and metabolic measurements. Results Compared with controls, serum fructose and uric acid levels were significantly increased in women with PCOS and patients with PCOS accompanied by metabolic disorders exhibited higher serum fructose and uric acid levels (P < 0.001). Restricted cubic splines indicated that serum uric acid levels linearly and positively correlated with serum fructose levels in women with PCOS (Poverall < 0.001, Pnon-linear = 0.30), whereas no correlation was found in controls (Poverall = 0.712, Pnon-linear = 0.43). Additionally, even after adjusting for confounding factors, serum fructose levels were an independent risk factor for hyperuricemia in patients with PCOS (P = 0.001; odds ratio, 1.380; 95% confidence interval, 1.207–1.577). Conclusions There was a significantly positive association of elevated uric acid levels with serum fructose levels in PCOS and was closely correlated with PCOS-related metabolic disorders, highlighting the importance of further research into the biological mechanisms of fructose and uric acid in the development of PCOS. Funding National Natural Science Foundation of China (No. 82071607 and 32100691); LiaoNing Revitalization Talents Program (No. XLYC1907071); Fok Ying Tung Education Foundation (No. 151039); Key Research and Development Program of Liaoning Province (No. 2018225062); Outstanding Scientific Fund of Shengjing Hospital (No. 202003). Keywords Fructose; Uric acid; PCOS; Metabolic disorder

show abstract

Metformin improves d-galactose induced premature ovarian insufficiency through PI3K-Akt-FOXO3a pathway

Ellibishy,

Tarek,

Abd-Elsalam

et al. 2024

Advances in Medical Sciences

View full text Add to dashboard Cite

Association of galactose and insulin resistance in polycystic ovary syndrome: A case-control study

Cited by 4 publications

References 26 publications

Distinct Metabolomic Profiling of Serum Samples from High-Fat-Diet-Induced Insulin-Resistant Mice

Distinct Metabolomic Profiling of Serum Samples from High-Fat-Diet-Induced Insulin-Resistant Mice

Fructose-associated elevation of serum uric acid levels may be involved in metabolic disorders in polycystic ovary syndrome: A case-control study

Metformin improves d-galactose induced premature ovarian insufficiency through PI3K-Akt-FOXO3a pathway

Contact Info

Product

Resources

About