Association of HPV genotypes with external anogenital warts: a cross sectional study

Al‐Awadhi, Rana; Al-Mutairi, Nawaf; Albatineh, Ahmed N.; Chehadeh, Wassim

doi:10.1186/s12879-019-4005-4

Cited by 21 publications

(23 citation statements)

References 29 publications

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“…In line with this study, a cross-sectional study in Kuwait on 156 patients with genital warts showed that 102/156 (65.4%) of the patients were infected by LR-HPV and 54/156 (34.6%) of the patients were infected by HR-HPV. About 88.4% of the patients in the aforementioned study had single infection and 11.6% had multiple infections (Al-Awadhi et al, 2019). Another study in Spain showed that the frequency of LR-HPV infection was 63/138 (45.6%) in their patients and 71/138 (41.4%) of anogenital warts patients were infected by HR-HPV (Arroyo et al, 2016).…”

Section: P16 Ink4a Expression In Ca Lesionsmentioning

confidence: 80%

p16INK4A Expression in Condyloma Acuminata Lesions Associated with High-Risk Human Papillomavirus Infection

Mastutik

Rahniayu

Arista

et al. 2021

Asian Pac J Cancer Prev

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Objective: The objective of this study was to discover the possible correlation between p16INK4A expression and the LR/HR-HPV infection in condyloma acuminate (CA) lesions. Materials and Method: This cross-sectional study was conducted during January-December 2017 on 33 CA patients. The expression of p16 INK4A was detected by immunohistochemistry (IHC) staining. The positive interpretation was carried out by scoring which score 0 was negative, score 1 was sporadic, score 2 was focal, and score 3 was diffuses. The HPV genotypes were identified by reverse line blot, and 40 genotypes of HPV detected, including HR-HPV (HPVs 16, 18, 26, 31, 33,35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68a, 68b, 69, 73, and 82) and LR-HPV (HPVs 6, 11, 40, 42, 43, 44, 54, 55, 61, 62, 64, 70, 71, 72, 81, 83, 84, 87, 89, and 90). Results: The expression of p16 INK4A was significantly correlated with HR-HPV infection. Patients infected with HR-HPV had 0.644 times higher possibility to express p16 INK4A gene compared to those infected with LR-HPV. LR-HPV genotypes detected in CA patients were HPVs 6, 11, 42, 61, 54, 81, 87, 89, and 90 and HR-HPV genotypes were HPVs 18, 26, 45, 51, 52, 67, 68B, 69, and 82. LR-HPV was found in 19/33 of patients and HR-HPV was in 14/33 of patients. The expression of p16 INK4A in CA lesions was diffuse in15.2% of patients, was focal in 24.2% of patients , was sporadic in 39.4% of patients were, and was negative in 21.2% of patients . In LR-HPV group, there was no diffuse expression, focal expression was observed in 15.8%, sporadic in 47.4%, and negative in 36.8%, while in HR-HPV group, p16 INK4A expression was detected in all lesions , in a way that its expression was diffuse in 35.7%, focal in 35.7%, and sporadic in 28.6%. Conclusion: IHC is a routine method in histopathological diagnosis, therefore the detection of p16 INK4A expression by IHC can be used as a biomarker for HR-HPV infection diagnosis.

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Section: P16 Ink4a Expression In Ca Lesionsmentioning

confidence: 80%

p16INK4A Expression in Condyloma Acuminata Lesions Associated with High-Risk Human Papillomavirus Infection

Mastutik

Rahniayu

Arista

et al. 2021

Asian Pac J Cancer Prev

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“…Blomberg et al indicated that the persistent HPV infection is the strongest risk factor for developing HPV-associated precancers and cancers [ 20 ]. The literature data indicate that patients with anogenital warts of one to six months duration were three times more likely to have oncogenic HPV infection compared to those with less than one month [ 7 , 21 ]. Hasanzadeh et al have shown that the coexistence of high-risk and low-risk HPV types infection may be associated with both an increased risk of the development of genital warts and the risk of persistent and recurrent HPV infections [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Those findings are confirmed by the results of our research, in which the presence of high-risk HPV types was associated with a worse clinical clearance rate and eradication rate of HPV ( p = 0.05, Figure 2 C) in comparison to the low-risk ones ( p = 0.0003). Thus, the HPV DNA detection is the indicator of the infection severity and the prognostic factor of treatment duration [ 5 , 7 , 12 ]. Wang et al made the duration of ALA-PDT treatment dependent on obtaining HPV DNA eradication confirmed by two negative tests [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Genital warts are commonly associated with HPV6 and HPV11. However, studies conducted in patients with clinical lesions have shown the possibility of additional infection with many other types of HPV [ 4 , 5 , 6 , 7 ]. Therapeutic approaches used in the treatment of genital warts can be divided into surgical ones such as cryotherapy, surgical excision, curettage, electrocoagulation or ablative laser treatment, and pharmacological methods, which include local immune modulators such as 5% imiquimod cream or antimitotic agents such as the drug podophyllotoxin [ 1 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients

Owczarek

Słowińska

Walecka

et al. 2021

Life

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: Background: Genital warts are the manifestation of the human papillomavirus (HPV) infection, which may last for weeks or months before the clinical presentation. The primary aim of the study was the correlation of the DNA HPV genotypes eradication with the treatment response in male patients with persistent genital warts. Methods: Twenty-one male patients (age range: 22–58) after failure of cryotherapy and podophyllotoxin treatment were enrolled in the study. Genetic tests (Real Time - PCR method) analyzed the presence of DNA-HPV before and 6 months after four sessions (4 weeks apart) of photodynamic therapy with 5-aminolaevulinic acid (ALA-PDT). The treatment efficacy was evaluated before each PDT session and at the end of the study. Results: The single HPV DNA type was present in 15/21 of the patients (13/15 HPV6). The high-risk HPV types were found in 8/21 subjects, of which 6/8 had several types. Six months after four sessions of PDT, complete response was found in 16/21 (76.19%; p = 0.0007) of patients, and DNA HPV clearance was found in 66.67% (p = 0.03). The eradication rate differed among patients with primary low-risk and high-risk HPV types—76.92% (10/13; p = 0.0003) and 50% (4/8; p = 0.05) respectively. Conclusion: ALA-PDT is an effective treatment even after the failure of previous modalities. The persistence of clinical lesions and high oncological risk HPV types should be an indication for treatment prolongation.

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“…It has been concluded that HPV carries a burden on almost a third of the communities worldwide. 5 , 2 Human papillomavirus has several genotypes, some of which are mainly responsible for the genital warts, namely genotypes 6 and 11. In contrast, the high-risk genotypes 16 and 18 are responsible for approximately 70% of all cervical cancers.…”

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confidence: 99%

Epidemiological characteristics of cervical cancer in a tertiary care hospital, western Saudi Arabia

Farahat

Faqih

Alharbi

et al. 2021

SMJ

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Objectives: To investigate the epidemiological characteristics of cervical cancer cases reported at a tertiary care teaching hospital in western Saudi Arabia. Methods: A retrospective chart review was conducted on medical records of patients diagnosed with cervical cancer at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Data were collected on demographic characteristics, histological types and stage, treatment modalities, and disease outcomes. Results: Cervical cancer was diagnosed among 89 patients from 2002 to 2018. History of pap smear was reported among 31 cases (34.8%). Squamous cell carcinoma was the most common reported histopathological subtype. Almost one third (29.2%) of the patients were at stage III or IV at the time of diagnosis. The most frequent treatment regimen was combined radio/chemotherapy. Kaplan-Meier analysis showed an overall survival rate of 81.5%. Conclusion: The lack of an effective screening program for cervical cancer increases the likelihood of a late diagnosis and higher rates of complications and mortality. Public health programs should focus on cancer screening, screening, and reporting HPV infections, and supporting HPV vaccination activities.

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Association of HPV genotypes with external anogenital warts: a cross sectional study

Cited by 21 publications

References 29 publications

p16INK4A Expression in Condyloma Acuminata Lesions Associated with High-Risk Human Papillomavirus Infection

p16INK4A Expression in Condyloma Acuminata Lesions Associated with High-Risk Human Papillomavirus Infection

Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients

Epidemiological characteristics of cervical cancer in a tertiary care hospital, western Saudi Arabia

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