Association of Helicobacter pylori infection with atrophic gastritis and intestinal metaplasia

Abstract

These results suggest that atrophic gastritis is not a normal aging process, but instead is likely to be the result of H. pylori infection, while intestinal metaplasia is caused by both the aging process and H. pylori infection. A decreased risk of intestinal metaplasia found in uninfected female subjects may partly explain the lower prevalence of gastric cancer in females than in males.

Histopathological spectrum of gastrointestinal lesions - an experience in a tertiary care centre in South India

“…In this study, intestinal metaplasia along with chronic gastritis and H.Pylori positivity was found in two gastric biopsies 3 .…”

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

“…Whereas, atrophic gastritis appeared highly at range of age 41-50 years, intestinal metaplasia at range of age 51-60 years, gastric cancer at range of age 61-70 years, compared to chronic which manifests at early age of 21-40 years. These results are reinforced by the study of Kenji et al [28] which demonstrated the existence of a strong significant positive association between age, H. pylori infection and the risk of gastric atrophy and intestinal metaplasia [28]. Also, Salles et al [29] have revealed that H. pylori infection is a chronic gastric infection increased with age.…”

Helicobacter pylori and histopathological findings in patients with dyspepsia

“…They found the rate of atrophic gastritis as 82.9% in the Hp-infected group and as 9.8% in the non-infected group. Similarly, the rates of IM were 43.1% and 6.2% in the infected and non-infected groups, respectively (37,38). Topal et al (39) showed that the greater the intensity of Hp, the greater the degree of chronic gastritis and atrophy; a statistically significant positive correlation was defined between them.…”