Association of IL‐1β +3954 C/T and IL‐10‐1082 G/A Cytokine Gene Polymorphisms with Susceptibility to Tuberculosis

Abstract

Tuberculosis (TB) constitutes the major cause of death due to infectious diseases. Cytokines play a major role in defence against Mycobacterium tuberculosis infection. Polymorphisms in the genes encoding various cytokines have been associated with tuberculosis susceptibility. Household contacts (HHC) are at increased risk of developing the disease. In this study, we examined the association of IL-1b and IL-10 cytokine gene polymorphisms with risk of developing tuberculosis in TB patients, their HHC and healthy controls (HC) using JavaStat and SPSS. Multifactor dimensionality reduction (MDR) analyses were performed to explore the potential gene-gene interactions. The genotype and allele frequencies of IL-1b +3954C/T polymorphism did not vary significantly between TB patients and HC. GG (P < 0.005, OR = 0.219 and 95% CI = 0.059-0.735) and GA (P < 0.0001, OR = 2.938 and 95% CI = 1.526-5.696) genotypes of IL-10-1082 G/A polymorphism were found to be significantly associated with patients versus HC. HHC with CC (P < 0.03, OR = 1.833 and 95% CI = 1.1-3.35) genotype in IL-1b and GA (P < 0.0001, OR = 4.612 and 95% CI = 2.225-9.702) genotype in IL-10 were at increased risk of developing tuberculosis. MDR tests revealed high-risk genotypes in IL-1b and IL-10 based on the association model. Our results demonstrate that the polymorphisms of IL-1b and IL-10 genes may be valuable markers to predict the risk for the development of TB in household contacts.

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

“…Previous studies have reported that cytokine genes contribute to susceptibility of TB, such as interferon-1β, interleukin (IL)-3, IL-6, IL-10, and IL-12B IL-17 as well as IL-18 (Selvaraj et al, 2008;Abhimanyu et al, 2011;Meenakshi et al, 2013;Feng et al, 2014;Tiwari et al, 2014;Zhang et al, 2014). However, the results have been inconsistent.…”

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

“…There are 29 case-control studies concerning -1082G/A polymorphism [16]–[44], 14 case-control studies concerning -819T/C polymorphism [16], [18], [20]–[23], [25], [31], [33], [37]–[39], [42], [45], and 16 case-control studies concerning -592A/C polymorphism [16], [20]–[25], [28], [31], [33], [37]–[40], [45], [46]. Among the 31 eligible studies, 17 of them were of Asians [16], [18], [19], [26], [28], [30]–[32], [34], [36], [39], [41]–[44], [46], 6 studies were of Europeans [17], [21], [25], [27], [35], [37], 5 studies were of Africans [20], [22], [29], [33], [38], and 3 studies were of Americans [23], [24], [40]. Controls were selected from healthy population in all studies and most studies used frequency-matched controls to the cases by age, sex, or ethnicity.…”

IL-1β +3953C/T, −511T/C and IL-6 −174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis

“…1. The search of the selected databases retrieved 15 potentially relevant articles (Amirzargar et al, 2006;Bellamy et al, 1998;Wilkinson et al, 1999;Delgado et al, 2002;Awomoyi et al, 2005;Gomez et al, 2006;Sun et al, 2007;Naslednikova et al, 2009;Trajkov et al, 2009;Meenakshi et al, 2013;Oral et al, 2006;Henao et al, 2006;Selvaraj et al, 2008;Ansari et al, 2011;Zhang et al, 2012), including 3983 cases and 3996 controls, according to inclusion and exclusion criteria. There were 7 case-control studies concerning IL1β +3953C/T polymorphism, 8 case-control studies for IL1β-511T/C polymorphism, and 7 case-control studies about IL-6 − 174G/C polymorphism.…”