Association of lymphocytic colitis and lactase deficiency in pediatric population

Sun, Jihong; Ji, Lin; Parashette, Kalayan; Zhang, Jianjun; Fan, Rong

doi:10.1016/j.prp.2014.11.009

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…The difference in prevalence of insufficient lactase production in the patients with and without LC and EGID could indicate that there was an association between these two conditions and insufficient lactase production, as found in other studies . Thus, it seems important to screen for lactase deficiency in LC and EGID, as some cases may be linked to lactase deficiency, primary or acquired, and may be treated effectively by a lactose‐free diet .…”

Section: Discussionmentioning

confidence: 64%

“…It is unknown if lactase deficiency is transitional or secondary to some other unidentified aetiology of LC or EGID, but generally, besides LC and EGID, gastrointestinal endoscopy in patients with RAP can reveal insufficient lactase production and the RAP can be eliminated with a lactose‐free diet .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, enzyme activity testing of duodenal disaccharides was performed from small bowel tissue samples. This clarified any occurrence of lactase deficiency as a possible cause of RAP and any possible association between lactase deficiency and LC or EGID . Samples were evaluated at a biochemical department.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Retrospective study recommends endoscopy when diagnosing lymphocytic colitis or eosinophilic gastrointestinal disorder in children with abdominal pain

Tilma

2018

Acta Paediatrica

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Retrospective study recommends endoscopy when diagnosing lymphocytic colitis or eosinophilic gastrointestinal disorder in children with abdominal pain

Tilma

2018

Acta Paediatrica

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“…The variable presentations of CSID, also called GSID, can also delay diagnosis until teenage years and even adulthood. Furthermore, disaccharidase deficiencies can coexist with other gastrointestinal disorders, such as IBD, celiac disease, and lymphocytic colitis [25]. It is important to note that the prevalence of disaccharidase deficiency in many study populations is biased, as the children that were tested were being investigated for a gastrointestinal complaint, thus it may not represent the prevalence of their deficiency in the pediatric population at large.…”

Section: Discussionmentioning

confidence: 99%

“…In a retrospective study spanning eleven years, Sun et al (2015) reviewed the histologic specimens from ten pediatric patients, aged 5 to 18 years, who met diagnostic criteria for lymphocytic colitis. The authors identified a statistically significant correlation between lymphocytic colitis and lactase deficiency, indicating that disaccharidase deficiencies could be an additional mechanism of diarrhea in this group of patients [25].…”

Section: Disaccharidase Deficiencies Can Coexist With Organic Disementioning

confidence: 99%

The Role of Disaccharidase Deficiencies in Functional Abdominal Pain Disorders—A Narrative Review

Puertolas

Fifi

2018

Nutrients

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Disaccharidase deficiencies are reportedly underdiagnosed in pediatric populations. Though typically thought to cause diarrheal disease, they can also be a cause of abdominal pain and dyspepsia, and patients diagnosed with these functional disorders may actually have associated enzyme deficiencies. While the effects of lactose deficiency have been widely studied, sucrase, maltase, and isomaltase are less frequently considered when approaching a patient with an apparent functional abdominal pain disorder. This review seeks to provide an up-to-date narrative on the current scientific literature on the possible role of sucrase, maltase, and isomaltase deficiency in pediatric functional gastrointestinal disorders.

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Bacterial lactase genes diversity in intestinal mucosa of dysbacterial diarrhea mice treated with Qiweibaizhu powder

Long

Liu

et al. 2018

3 Biotech

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The current research tried to investigate the effect of Qiweibaizhu powder (QWBZP) on intestinal mucosa bacterial lactase gene from dysbacterial diarrhea mice, as the good therapeutic mechanism of QWBZP on antibiotics-induced diarrhea. Dysbacterial diarrhea mice model was constructed by gastric perfusion with mixture of cephradine capsules and gentamicin sulfate (23.33 mL kg −1 day −1 ) for 5 days. After the success of establishing diarrhea, the mice in treatment group were gavaged with QWBZP for 3 days. Intestinal mucosa in each group was collected, and diversity of bacterial lactase genes in intestinal mucosa of mice was carried out by Miseq metagenome sequencing. The results showed the Chao1, ACE, Simpson and Shannon indices in treatment group were lower than model group and were similar to control group. The same result was obtained from the operational taxonomic units (OTUs). There were 298, 435 and 254 OTUs in the control group, model group and treatment group, respectively. Principal component analysis (PCA) indicated that samples distribution in both normal and treatment groups were relatively intensive, distances among individuals were small, while opposite results were observed in model group. Moreover, antibiotics increased the diversity and abundance of bacterial lactase genes at phylum and genus levels. However, they decreased and were similar to control group after treating with QWBZP. Our results indicate that QWBZP has a positive effect on the recovery of bacterial lactase gene diversity to normal level. In addition, QWBZP increase the abundance of Lysobacter and Eukaryota.

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Association of lymphocytic colitis and lactase deficiency in pediatric population

Cited by 12 publications

References 21 publications

Retrospective study recommends endoscopy when diagnosing lymphocytic colitis or eosinophilic gastrointestinal disorder in children with abdominal pain

Retrospective study recommends endoscopy when diagnosing lymphocytic colitis or eosinophilic gastrointestinal disorder in children with abdominal pain

The Role of Disaccharidase Deficiencies in Functional Abdominal Pain Disorders—A Narrative Review

Bacterial lactase genes diversity in intestinal mucosa of dysbacterial diarrhea mice treated with Qiweibaizhu powder

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