Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

Fang, Ziwei; Zhou, Lei; Bao, Yuanyuan; Ding, Wei; H, Shi; Luo, Xinping; Hu, Renming

doi:10.1371/journal.pone.0022563

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…All these findings support the significant association between plasma serglycin levels and SS observed in our study. As a well-known acute phase protein in cardiovascular diseases, hsCRP has been confirmed to be of a diagnostic value in CAD and to be associated with coronary angiographic severity [18]. Our data showed that plasma serglycin levels had a similar diagnostic value to that of hsCRP levels for SAP.…”

Section: Discussionsupporting

confidence: 67%

The association between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris

et al. 2018

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Section: Discussionsupporting

confidence: 67%

The association between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris

et al. 2018

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“…As a well-known acute phase protein in cardiovascular diseases, hsCRP has been confirmed to be a diagnostic factor for CAD and to be associated with coronary angiographic severity. [ 25 ] Our data showed that plasma AAT levels had a similar diagnostic value to that of hsCRP levels for SAP. However, the plasma AAT level was more powerful than the hsCRP level for identifying SAP patients with a higher GS.…”

Section: Discussionsupporting

confidence: 58%

Plasma α1-antitrypsin

Chai

et al. 2015

Chinese Medical Journal

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Background:As an acute phase protein, α1-antitrypsin (AAT) has been extensively studied in acute coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP). The purpose of the present study was to investigate the association between AAT plasma levels and SAP.Methods:Overall, 103 SAP patients diagnosed by coronary angiography and clinical manifestations and 118 control subjects matched for age and gender were enrolled in this case-control study. Plasma levels of AAT, high-sensitivity C-reactive protein (hsCRP), lipid profiles and other clinical parameters were assayed for all participants. The severity of coronary lesions was evaluated based on the Gensini score (GS) assessed by coronary angiography.Results:Positively correlated with the GS (r = 0.564, P < 0.001), the plasma AAT level in the SAP group was significantly higher than that in the control group (142.08 ± 19.61 mg/dl vs. 125.50 ± 19.67 mg/dl, P < 0.001). The plasma AAT level was an independent predictor for both SAP (odds ratio [OR] = 1.037, 95% confidence interval [CI]: 1.020–1.054, P < 0.001) and a high GS (OR = 1.087, 95% CI: 1.051–1.124, P < 0.001) in a multivariate logistic regression model. In the receiver operating characteristic curve analysis, plasma AAT level was found to have a larger area under the curve (AUC) for predicting a high GS (AUC = 0.858, 95% CI: 0.788–0.929, P < 0.001) than that of hsCRP (AUC = 0.665, 95% CI: 0.557–0.773, P = 0.006; Z = 2.9363, P < 0.001), with an optimal cut-off value of 137.85 mg/dl (sensitivity: 94.3%, specificity: 68.2%).Conclusions:Plasma AAT levels correlate with both the presence and severity of coronary stenosis in patients with SAP, suggesting that it could be a potential predictive marker of severe stenosis in SAP patients.

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“…10 Mechanisms that contribute to accelerated atherosclerosis as age increases include increased fibrinogen, coagulation factor changes (V, VIII, IX and XIIa), von-Willebrand factor and increased plasminogen activator inhibitor that may inhibit fibrinolysis process.…”

Section: Methodsmentioning

confidence: 99%

Correlation between Carotid Intimal-Media Thickness and Coronary Artery Disease Severity in Stable Coronary Artery Disease Patients

Haris

Hariawan

Ismail

et al. 2018

Acta Cardiol Indones

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Background: Atherosclerosis is a fundamental process in the natural course of coronary heart disease (CHD), carotid artery disease and peripheral artery disease. Atherosclerosis is caused by an imbalance of homeostasis in the level of the endothelial layer and the presence of risk factors. The manifestations of coronary atherosclerosis have a wide spectrum of diseases, ranging from subclinical to clinical phases. In patients without CHD symptoms, changes in carotid artery morphology include carotid intimal-media thickness (CIMT) and carotid plaques which correlated with CHD. This study aims to see the relationship between CIMT with the severity of coronary lesions in stable coronary artery disease. Methods: The study was an analytical observational research using cross sectional design. Data was taken by consecutive sampling from outpatient hospital clinic. The CIMT score was obtained from the examination of a communis carotid artery using a B-mode ultrasound device. The value of CIMT is divided into 2 groups based on the value of the sensitivity curve and the specificity curve. The value of Syntax was obtained from the catheterization laboratory and the factors that influenced it were recorded. Pearson correlation test is used to analyze the relationship of CIMT and Syntax value. The logistic regression test used for multivariate test. Results: Of the 58 patients, there were 33 subjects who had a CIMT score of > 0.71 mm and 25 subjects who had a CIMT score of ≤0.71 mm. There is a positive correlation (r = 0.403; p <0.05) between CIMT value and Syntax value. Subjects who have high Syntax value in the group with a CIMT value >0.71 mm compared to CIMT values ≤0.71 mm were 29 versus 4 (RR: 1.831; CI 95%: 1.194-2.807; p = 0.01). A multivariate test showed CIMT consistently as a independent risk factor of Syntax value in stable coronary artery disease with RP 5.27 (CI 95%: 1.306-25.047; p = 0.021). Conclusion:The increase in CIMT value has a significant positive correlation with the Syntax value. A CIMT > 0.71 mm is a independent risk factor of high Syntax value in stable coronary artery disease with prevalence ratio 5.27.

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Association of NT-proBNP and Multiple Biomarkers with Severity of Angiographic Coronary Artery Disease in Diabetic and Pre-Diabetic Chinese Patients

Cited by 11 publications

References 23 publications

The association between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris

The association between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris

Plasma α1-antitrypsin

Correlation between Carotid Intimal-Media Thickness and Coronary Artery Disease Severity in Stable Coronary Artery Disease Patients

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