Association of serum lncRNA H19 expression with inflammatory and oxidative stress markers and routine biochemical parameters in chronic kidney disease

Okuyan, Hamza Malik; Doğan, Serdar; Terzi̇, Menderes Yusuf; Begen, Mehmet A.; Turğut, Faruk

doi:10.1007/s10157-021-02023-w

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…In diabetic rats with cardiac and renal complications, lncRNA H19 and Mfn-2 mRNA showed altered expression with a statistically significant downregulation of Mfn-2 mRNA expression in renal tissues 50 . In a case-control study, lncRNA H19 expressions were increased in CKD patients which had a significant correlation with decreased inflammation, glomerular filtration rate in these patients 51 .…”

Section: The Functions Of H19 In Diabetic Nephropathymentioning

confidence: 96%

“…Glucose metabolism Hippocampal neuron apoptosis and [25] Wnt3, β-catenin, TCF-1, Bax, caspase-8, caspase-3, GSK-3β, Bel-2, Wnt signaling [28] CNS complications Glucose homeostasis and β cell function [9,[13][14] MiR-let 7, PI3K/AKT [9] H19/miR-1 40/HE4 [17] Fox O1 [18] Hnf4a [21] Diabetic cardiomyopathy Oxidative stress, inflammation, apoptosis, and autophagy [32][33] H 19/microRNA-675 axis, VDAC 1 [33,[36][37] Diabetic retinopathy Endothelial-mesenchymal transition [40] NOX4 and eNOS/NO signalings [43] Diabetic nephropathy Vitamin D receptor, miR-675 [45] EGR1 [45] Diabetic enteropathy IECs [49] MiR-141-3p, β-catenin [49] Diabetic wounds Angiogenesis [51] H 19/let-7, insulin-PI3 KA-kt pathway [9] Proliferation activity of keloid fibroblasts [53] Lymphatic endothelial cells [60] EZH2-mediated histone methylation, HIF-1a signal pathway [61] Gestational diabetes Igf2 and H 19 gene expression [13] Methylation of the H 19-Igf2 ICR [72] CNS: Central nervous system; ICR: Imprinting control region; IECs: Intestinal epithelial cells; EGR1: Early growth response protein 1.…”

Section: Dm and Complications Functions [Ref]mentioning

confidence: 99%

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Recent Advances of LncRNA H19 in Diabetes

Wang

Sun

2022

Horm Metab Res

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Diabetes mellitus (DM) causes damage to major organs, including the heart, liver, brain, kidneys, eyes, and blood vessels, threatening the health of the individuals. Emerging evidence has demonstrated that lncRNAs has important functions in the pathogenesis of human diseases, such as cancers, neurodegenerative diseases, cardiac fibroblast phenotypes, hypertension, heart failure, atherosclerosis and diabetes. Recently, H19, a lncRNA, has been reported to shown to participate in the regulatory process of muscle differentiation, glucose metabolism, and tumor metastasis, as well as endometrial development. However, the roles of H19 in DM were still not completely understood. This review was conducted to summarize the functions of H19 in diabetes and discuss the challenges and possible strategies of H19 in DM.

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Section: The Functions Of H19 In Diabetic Nephropathymentioning

confidence: 96%

Section: Dm and Complications Functions [Ref]mentioning

confidence: 99%

Recent Advances of LncRNA H19 in Diabetes

Wang

Sun

2022

Horm Metab Res

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“…Correlation analysis revealed a relation between oxidative stress and lipoperoxidation products, highlighting the role of these components in the deterioration of renal structures, which increases in severity as the disease progresses (Okuyan et al, 2021, Rajeshwari et al, 2019.…”

Section: Discussionmentioning

confidence: 99%

Indicators of Oxidative Stress and Antioxidant Defense in Diabetic Nephropathy

Mohammed¹,

Zohra²,

Zohra³

et al. 2022

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Diabetes mellitus is a chronic metabolic disorder, which can cause damage to multiple organs; one of the long-term effects of diabetes is diabetic nephropathy; oxidative stress is thought to play a role in the development of diabetic nephropathy, as it can induce an inflammatory response and damage cells by disrupting their redox homeostasis; The study's goal was to assess the levels of oxidative damage and antioxidant protection in diabetic nephropathy patients. During routine medical examinations, 105 patients and 101 controls were selected; in serum, the reaction of thiobarbituric acid with malondialdehyde can be quantified by measuring the intensity of a pink color produced at 95°C. The same method is used to assess the degree of oxidation of free-cholesterol-LDL; total plasma antioxidant status was determined by a colorimetric enzymatic peroxidase method. Erythrocyte superoxide dismutase activity was determined by xanthine oxidase, catalase and glutathione peroxidase activities were measured by a colorimetric method; ascorbic acid was measured in an acidic solution using a colorimetric technique at a wavelength of 465 nanometers. Retinol and tocopherol were isolated from serum by liquid-liquid extraction and immediately injected into a high-performance liquid chromatography system. The results show that patients had 1.77 times higher serum TBARS, 2.77 times higher free-cholesterol-LDL-TBARS, 1.43 times lower total antioxidant status, 1.30 times lower superoxide dismutase activity, 1.19 times lower catalase activity, 1.28 times lower glutathione peroxidase activity, 1.83 times lower α-tocopherol, 1.33 times lower ascorbic acid, and 1. 15 times lower retinol than controls; the results of the present research also demonstrate that significant differences were observed between patients and controls in blood urea (p=.013), serum creatinine (p=.007), uric acid (p=.015), albumin (p=.018), and glomerular filtration rate (GFR) (p=.006). In diabetic nephropathy, there is a negative correlation between glomerular filtration rate and oxidant status parameters, while there is a positive correlation with antioxidant status indicators.

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“…H19 lncRNA, together with miR-17 and fibronectin, forms a regulatory network involved in renal fibrosis [ 92 ]. Its expression has been significantly correlated with oxidative stress and inflammatory markers such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in patients with CKD [ 93 , 94 ].…”

Section: The Role Of Lncrna In Kidney Diseasementioning

confidence: 99%

The Mission of Long Non-Coding RNAs in Human Adult Renal Stem/Progenitor Cells and Renal Diseases

Giannuzzi

Maiullari

Gesualdo

et al. 2023

Cells

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Long non-coding RNAs (lncRNAs) are a large, heterogeneous class of transcripts and key regulators of gene expression at both the transcriptional and post-transcriptional levels in different cellular contexts and biological processes. Understanding the potential mechanisms of action of lncRNAs and their role in disease onset and development may open up new possibilities for therapeutic approaches in the future. LncRNAs also play an important role in renal pathogenesis. However, little is known about lncRNAs that are expressed in the healthy kidney and that are involved in renal cell homeostasis and development, and even less is known about lncRNAs involved in human adult renal stem/progenitor cells (ARPC) homeostasis. Here we give a thorough overview of the biogenesis, degradation, and functions of lncRNAs and highlight our current understanding of their functional roles in kidney diseases. We also discuss how lncRNAs regulate stem cell biology, focusing finally on their role in human adult renal stem/progenitor cells, in which the lncRNA HOTAIR prevents them from becoming senescent and supports these cells to secrete high quantities of α-Klotho, an anti-aging protein capable of influencing the surrounding tissues and therefore modulating the renal aging.

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Association of serum lncRNA H19 expression with inflammatory and oxidative stress markers and routine biochemical parameters in chronic kidney disease

Cited by 18 publications

References 13 publications

Recent Advances of LncRNA H19 in Diabetes

Recent Advances of LncRNA H19 in Diabetes

Indicators of Oxidative Stress and Antioxidant Defense in Diabetic Nephropathy

The Mission of Long Non-Coding RNAs in Human Adult Renal Stem/Progenitor Cells and Renal Diseases

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