Association of skin autofluorescence with periodontal inflammation in adults with type 1 diabetes

Duda-Sobczak, Anna; Lipski, Jakub; Tarnowski, Mateusz; Surdacka, Anna; Zozulińska‐Ziółkiewicz, Dorota; Wyganowska‐Świątkowska, Marzena

doi:10.20452/pamw.4129

Cited by 6 publications

(5 citation statements)

References 1 publication

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“…Plaque accumulation is generally associated with tooth-brushing habits. In our previous study, we showed that the bleeding score was independent of oral hygiene in patients with T1D and was associated with long-term metabolic control of diabetes (the assessment of the tissue accumulation of advanced glycation end products (AGEs) by measuring skin autofluorescence, AF) [ 16 ]. According to the published data, the TSH level correlates with the vessel’s condition [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease—A Preliminary Study

Duda-Sobczak

Zozulińska−Ziółkiewicz

Wyganowska

2023

IJERPH

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Periodontal disease has been postulated as one of the chronic complications of diabetes. The prevalence of autoimmune thyroiditis in type 1 diabetes (T1D) is higher. The aim of the study was to determine the association between the presence of thyroiditis and gingival status in adults with T1D. A total of 264 patients, 119 men aged 18–45, diagnosed with T1D were included. For further analysis, the study group was divided into two subgroups, with or without autoimmune thyroiditis. Gingival status was assessed with the use of gingival indices. Patients diagnosed with T1D and thyroiditis presented lower plaque accumulation (p = 0.01) and lower-grade gingivitis (p = 0.02). Approximal Plaque Index (API) in all study groups correlated positively with age (Rs = 0.24; p = 0.0001), body mass index (BMI) (Rs = 0.22; p = 0.0008), hemoglobin A1c (HbA1c) (Rs = 0.18; p = 0.006), high-sensitivity C-Reactive Protein (hsCRP) (Rs = 0.17; p = 0.009), total cholesterol (T-Chol) (Rs = 0.17; p = 0.01) and negatively with thyroid-stimulating hormone (TSH) (Rs = −0.2; p = 0.02). Stepwise multivariate linear regression analysis indicated TSH, BMI and gender as independent predictors of dental plaque accumulation in patients with T1D. Autoimmune thyroiditis was associated with a lower accumulation of dental plaque and better gingival status in patients with T1D.

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Section: Discussionmentioning

confidence: 99%

Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease—A Preliminary Study

Duda-Sobczak

Zozulińska−Ziółkiewicz

Wyganowska

2023

IJERPH

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“…Further periodontal parameters such as CAL or PD, however, were not investigated. The authors conclude that sAF may be an indicator of early microvascular changes in gingival tissues appearing before any other periodontal conditions are visible [ 39 ]. Whether it is actually useful to measure sAF in routine dental diagnostic procedures must be clarified in further studies.…”

Section: Discussionmentioning

confidence: 99%

Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)

Reichert

Hofmann

Kohnert

et al. 2022

JCM

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Tissue concentrations of advanced glycation end product (AGE) and peripheral soluble receptor of AGE (sRAGE) levels may be associated with periodontitis severity. Both parameters and periodontitis might serve as outcome predictors for patients undergoing coronary artery bypass grafting (CABG). This study aimed to investigate possible associations between periodontitis and AGE/sRAGE. Ultimately, we wanted to examine whether AGE, sRAGE, and severe periodontitis are associated with the incidence of new cardiovascular events within 3 years of follow-up after CABG. Ninety-five patients with coronary vascular disease (CVD) (age 69 years, 88.3% males) needing CABG surgery were included. Periodontal diagnosis was made according to the guidelines of the “Centers for Disease Control and Prevention (CDC)” (2007) and staged according to the new classification of periodontal diseases (2018). AGE tissue concentrations were assessed as skin autofluorescence (sAF). sRAGE levels were determined by using a commercially available enzyme-linked immunoabsorbance assay (ELISA) kit. Univariate and multivariate baseline and survival analyses were carried out with Mann–Whitney U test, Chi² test, Kaplan–Meier curves with Log-Rank test, and logistic and Cox regression. sAF was identified as an independent risk indicator for severe periodontitis with respect to the cofactors age, gender, plaque index, and diabetes (adjusted odds ratio [OR] = 2.9, p = 0.028). The degree of subgingival inflammation assessed as a percentage of sites with bleeding on probing (BOP) was inversely correlated with sRAGE concentration (r = −0.189, p = 0.034). Both sAF (Hazard Ratio [HR] = 2.4, p = 0.004) and sRAGE (HR = 1.9, p = 0.031) increased the crude risk for new adverse events after CABG. The occurrence of severe periodontitis trends towards a higher risk for new cardiovascular events (HR = 1.8, p = 0.115). Applying multivariate Cox regression, only peripheral arterial disease (adjusted HR = 2.7, p = 0.006) and history of myocardial infarction (adjusted HR = 2.8, p = 0.010) proved to be independent risk factors for cardiovascular outcome. We conclude that sAF may represent a new, independent risk indicator for severe periodontitis. In contrast, sAF, sRAGE, and severe periodontitis were not independent prognostic factors for postoperative outcome in patients undergoing CABG.

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“…22 Moreover, gingival bleeding was shown to correlate positively with accumulation of AGEs in the skin assessed by measurement of skin autofluorescence in adults with T1D maintaining good oral hygiene. 23 The increased levels of inflammatory cytokines and growth factors and the activation of leukocytes are observed in chronic hyperglycemia. Presence of the subgingival bacterial biofilm yields interaction between bacterial by-products with mononuclear phagocytes and fibroblasts further inducing the release of proinflammatory cytokines.…”

Section: Pathomechanisms Linking Diabetes and Periodontal Diseasementioning

confidence: 99%

Type 1 Diabetes and Periodontal Health

Duda-Sobczak

Zozulińska−Ziółkiewicz

Wyganowska‐Świątkowska

2018

Clinical Therapeutics

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It is well established that hyperglycemia affects periodontal outcomes. A body of evidence, predominantly over the past 20 years supports significant independent associations between periodontal disease and glycemic control or complications of diabetes. Association between periodontal tissue and hyperglycemia is possible through altered cellular immunity, increased proliferation of bacteria, microangiopathy, and formation of the advanced glycation end products. However, most studies focus solely on patients with type 2 diabetes or diabetes in general. There is still the paucity of data concerning patients with type 1 diabetes (T1D). Here, the authors consider the possible mechanisms linking periodontal disease with diabetes, focusing mainly on T1D and discuss possible diagnostic and therapeutic approaches.

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Association of skin autofluorescence with periodontal inflammation in adults with type 1 diabetes

Cited by 6 publications

References 1 publication

Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease—A Preliminary Study

Better Gingival Status in Patients with Comorbidity of Type 1 Diabetes and Thyroiditis in Comparison with Patients with Type 1 Diabetes and No Thyroid Disease—A Preliminary Study

Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)

Type 1 Diabetes and Periodontal Health

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