Association of three insulin resistance indices with hypertension and body weight among Uyghur adults in rural areas of Xinjiang, China

Abstract

Obesity and insulin resistance are significant contributors to hypertension. There is a high prevalence of obesity among Uyghurs in the rural areas of Xinjiang, China. Therefore, this study aimed to explore the association between insulin resistance indices and hypertension according to different body weights in rural Uyghur residents of Xinjiang, China. A total of 12 813 local Uyghur residents were recruited for the study. Excluding those with incomplete data and those using antihypertensive, lipid-lowering, or glycemic drugs, 9577 permanent residents were eligible for the study. Three insulin resistance indicators were calculated: triglyceride to high-density lipoprotein cholesterol ratio, product of fasting triglyceride and glucose (TYG), and metabolic score for insulin resistance. Multivariate logistic regression analysis was performed to estimate the association between the three non-insulin-based insulin resistance indices and the risk of hypertension for different body weights. TYG was significantly associated with hypertension in the normal-weight group, particularly in women. In the obese group that was obese, all three indicators were associated with hypertension. Since TYG was associated with hypertension in the groups with normal weight and obesity, it may be useful as a reference indicator for insulin resistance. This indicator may provide a basis for the identification and management of hypertension risk among adults in the Uyghur population.

Association Between the Metabolic Score for Insulin Resistance and Hypertension in Adults: A Meta-Analysis

“…4b, p for subgroup difference all > 0.05). Results of meta-analysis with METS-IR analyzed in continuous variables also showed that METS-IR was associated with the risk of hypertension (four datasets [26][27][28], RR for 1-unit increment of METS-IR: 1.15, 95 % CI: 1.08 to 1.23, p < 0.001, I 2 = 79 %; ▶ Fig. 5).…”

“…As shown in Table 1 , eight observational studies, including two cohort studies 21 28 and six cross-sectional studies 22 23 24 25 26 27 , were included in the meta-analysis. These studies were published between 2019 and 2022, and performed in Mexico 21 , China 22 23 24 25 , 27 28 , and Japan 26 .…”

“…As shown in Table 1 , eight observational studies, including two cohort studies 21 28 and six cross-sectional studies 22 23 24 25 26 27 , were included in the meta-analysis. These studies were published between 2019 and 2022, and performed in Mexico 21 , China 22 23 24 25 , 27 28 , and Japan 26 . Four of them included community-derived adult population 21 23 , 26 27 , and the other four included adults for routine health check 22 24 , 25 28 .…”

“…These studies were published between 2019 and 2022, and performed in Mexico 21 , China 22 23 24 25 , 27 28 , and Japan 26 . Four of them included community-derived adult population 21 23 , 26 27 , and the other four included adults for routine health check 22 24 , 25 28 . Overall, 305 341 adults were included in the meta-analysis, and 47 887 (15.7%) of them had hypertension.…”

“…Then, an additional 147 articles were excluded since the contents of the titles and abstracts indicated that they were not relevant to the aim of the meta-analysis, which made a total of 18 studies for the full-text review. Finally, after excluding ten studies through full-text review, eight studies [21][22][23][24][25][26][27][28] were included. The reasons for the removing of the ten studies are also presented in ▶Fig.…”