Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort

Schiel, Julian; Tamm, Sandra; Holub, Florian; Petri, Roxana; Dashti, Hassan S.; Domschke, Katharina; Feige, Bernd; Lane, Jacqueline M.; Riemann, Dieter; Rutter, Martin K.; Saxena, Richa; Tahmasian, Masoud; Wang, Heming; Kyle, Simon D.; Spiegelhalder, Kai

doi:10.1016/j.biopsych.2022.05.023

Cited by 22 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, patients with insomnia do not necessarily have increased emotional reactivity to novel experiences, i.e., they do not show stronger initial emotional responses. A recent study with 25,758 participants of the United Kingdom Biobank showed no association between insomnia symptoms and limbic brain activation during an emotional task ( Schiel et al, 2022 ). However, the differences from regular sleepers become evident after sleeping ( Wassing and D’Rozario, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

Schalkwijk

Someren²,

Nicolai³

et al. 2023

Front. Hum. Neurosci.

View full text Add to dashboard Cite

IntroductionA new line of insomnia research focuses on the developmental trajectories from early live stress to insomnia in adulthood. Adverse childhood experiences (ACE’s) might create a vulnerability for later maladaptive coping with distress, as seen in chronic hyperarousal or insomnia. In an functional magnetic resonance imaging (fMRI) study, failure to dissociate the neurobiological components of shame from autobiographical shameful memories in insomnia was reflected by continued activation of the dorsal anterior cingulate cortex (dACC), which may be a result of maladaptive coping in the wake of ACE’s. Following up on that study, the current pilot study explores the relation between ACE’s, shame coping-styles, adult insomnia, hyperarousal, and neurobiology of autobiographical memory.MethodsWe used existing data (N = 57) from individuals with insomnia (N = 27) and controls (N = 30), and asked these participants to complete the childhood trauma questionnaire (CTQ). Two structural equation models were used to test the hypotheses that shame-coping styles and insomnia symptom severity mediate the association between ACE’s and (1) self-rated hyperarousal symptoms and (2) dACC activation to recall of autobiographical memories.ResultsFor the association between ACE’s and hyperarousal, there was a significant mediation of shame-coping style (p < 0.05). This model also indicated worse shame coping with more ACE’s (p < 0.05) and worse insomnia symptoms with more ACES’s (p < 0.05), but no association between shame coping and insomnia symptoms (p = 0.154). In contrast, dACC activation to recall of autobiographical memories could only be explained by its direct association with ACE’s (p < 0.05), albeit that in this model more ACE’s were also associated with worse insomnia symptoms.DiscussionThese findings could have an implication for the approach of treatment for insomnia. It could be focused more on trauma and emotional processing instead of conventional sleep interventions. Future studies are recommended to investigate the relationship mechanism between childhood trauma and insomnia, with additional factors of attachment styles, personality, and temperament.

show abstract

Section: Introductionmentioning

confidence: 99%

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

Schalkwijk

Someren²,

Nicolai³

et al. 2023

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Resting on this theoretical consideration and previous researches examining associations between different sleep measures and health outcomes 345 , sleep health mainly consists of six domains of sleep and circadian functioning: Regularity in sleep, Satisfaction with sleep/sleep quality, Alertness during waking hours, Timing of sleep, Sleep E ciency/Continuity, and Sleep Duration (Ru-SATED). Emerging studies also pointed out that there exit other domains that can be considered as relevant to the construction of sleep health, such as sleep quality 6 , insomnia symptoms 7 and sleep medication use 7 .…”

Section: Introductionmentioning

confidence: 99%

A Brain Connectome Biomarker for Sleep Health

Wang

Genon²,

Dong

et al. 2023

Preprint

View full text Add to dashboard Cite

Sleep health is both conceptually and operationally a composite concept containing multiple domains of sleep. In line with this, high dependence and interaction across different domains of sleep health encourage a transition in sleep health research from categorical to dimensional approaches that integrate neuroscience and sleep health. Here, we seek to identify the covariance patterns between multiple-sleep health domains and distributed intrinsic functional connectivity by applying a multivariate approach (partial least squares). This multivariate analysis revealed a composite sleep health dimension co-varying with connectivity patterns involving the attentional and thalamic networks and which appear relevant at the neuromolecular level. These findings were further replicated and generalized to several unseen independent datasets. Critically, the identified sleep-health related connectome showed diagnostic potential for insomnia disorder. These results together delineate a brain connectome biomarker for sleep health with high potential for clinical translation.

show abstract

“…We then examined how cognitive control activations changed as an effect of time on task, and whether such changes were related to any of the sleep health measures. Age, sex, years of education, as well as fMRI task performance were selected as covariates a-priori, to control for possible confounding factors related to sleep health, cognitive control function, and BOLD activation (Price et al 2006; Yarkoni et al 2009; Olsen et al 2015; Schiel et al 2022; Wassing and D’Rozario 2022).…”

mentioning

confidence: 99%

“…In fact, other dimensions of sleep health, in particular, the timing and variability of sleep, appear to be at least as closely linked to cognitive and brain function as sleep duration itself (Fuligni and Hardway 2006;Mezick et al 2009;Lemola et al 2013;Bei et al 2016;Owens et al 2016;Molzof et al 2018;Facer-Childs et al 2019;Gomez Fonseca and Genzel 2020;Hershner 2020;Lunsford-Avery et al 2020;Zhang et al 2020;Bredeli et al 2022;Stefansdottir et al 2022). To further elucidate the links between sleep, cognitive performance, and brain function, there is a need to include multidimensional assessment of sleep health within the context of normal, habitual sleep (van de Langenberg et al 2022;Schiel et al 2022).…”

mentioning

confidence: 99%

“…The interplay between sleep and cognitive function is likely mediated by brain structure and functioning (Avinun et al 2017; Alfini et al 2020; Grumbach et al 2020; Tahmasian et al 2020; Schiel et al 2022). Measures of poorer sleep health have been associated with lower white matter integrity (Yaffe et al 2016; Khalsa et al 2017; Grumbach et al 2020), lower gray matter volume and thickness (Sexton et al 2014; Cheng et al 2020; Kim et al 2021; Wang et al 2021), as well as altered functional connectivity within and between widespread brain regions (Curtis et al 2016; Cheng et al 2018; Tashjian et al 2018; Lunsford-Avery et al 2020).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Poorer Sleep Health is Associated With Altered Brain Activation During Cognitive Control Processing in Healthy Adults

Smevik

Habli

Saksvik

et al. 2022

Preprint

View full text Add to dashboard Cite

This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data was acquired from 81 healthy adults with normal sleep (41 females, age 20.96 - 39.58 years) during a test of cognitive control ("Not-X CPT"). Sleep health was assessed in the week before MRI scanning, using both objective (actigraphy) and self-report measures. Multiple measures indicating poorer sleep health - including later/more variable sleep timing, later chronotype preference, more insomnia symptoms and lower sleep efficiency - were associated with stronger and more widespread BOLD activations (adjusted for age, sex, education, and fMRI task performance). Poorer sleep health was predominantly associated with stronger reactive cognitive control activation, indicating an overall "hyper-reactive" brain state. Analysis of time-on-task effects showed that, with longer time on task, poorer sleep health was predominantly associated with increased proactive cognitive control activation, indicating recruitment of more neural resources over time. Finally, shorter objective sleep duration was associated with poorer task performance and lower BOLD activation with time on task. In conclusion, even in normal sleepers, relatively poorer sleep health is associated with altered cognitive control processing, possibly reflecting compensatory mechanisms and / or inefficient neural processing.

show abstract

Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort

Cited by 22 publications

References 62 publications

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

A Brain Connectome Biomarker for Sleep Health

Poorer Sleep Health is Associated With Altered Brain Activation During Cognitive Control Processing in Healthy Adults

Contact Info

Product

Resources

About