Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows

Haruna, Ishaku L.; Li, Yunhai; Ekegbu, Ugonna J.; Najafabadi, Hamed Amirpour; Zhou, Huitong; Hickford, Jonathan G. H.

doi:10.3390/ani10091447

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Polimorfisme gen MSTN diketahui memiliki peran penting dalam proses hipertrofi, peningkatan massa otot dan pertumbuhan sel. Banyak penelitian telah melaporkan asosiasi positif antara polimorfisme gen MSTN dengan sifat pertumbuhan dan sifat karkas pada beberapa spesies ternak, termasuk sapi (Zhang et al 2007, Fiems, 2012, Khasanah et al 2016, Haruna et al 2020, kambing (An et al 2011;Batubara 2017), domba (Haren et al 2020), ayam (Zhang et al 2020) dan itik (Lu et al 2011). Pada Tabel 1 ditampilkan polimorfisme gen MSTN pada beberapa bangsa sapi.…”

Section: Polmorfisme Gen Myostatin Dan Asosiasinya Terhadap Sifat Pertumbuhan Dan Karkasunclassified

“…Sebagaimana diketahui, inaktivasi gen MSTN dapat menghasilkan individu dengan fenotip unggul, berupa adanya peningkatan masa otot rangka, atau dikenal sebagai "double muscling". Polimorfisme gen MSTN juga dilaporkan pada sapi Bali, sapi Pasundan, sapi lokal di China, Korea dan Selandia Baru (Han et al 2012;Khasanah et al 2016;Nugroho et al 2017;Anwar et al 2020;Haruna et al 2020).…”

Section: Polmorfisme Gen Myostatin Dan Asosiasinya Terhadap Sifat Pertumbuhan Dan Karkasunclassified

“…Kombinasi dari SNP tersebut menghasilkan 4 tipe genotip, yaitu AA, AB, AC dan AD. Sapi bergenotip AD memiliki kadar asam lemak C10:0, C12:0 dan C12:1 yang lebih rendah dari pada sapi bergenotip AA (Haruna et al 2020).…”

Section: Polmorfisme Gen Myostatin Dan Asosiasinya Terhadap Sifat Pertumbuhan Dan Karkasunclassified

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Myostatin Gene as a Genetic Marker for Growth and Carcass Traits in Beef Cattle

Prihandini¹,

Hariyono

Tribudi

2021

WARTAZOA

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<p>Growth and carcass traits are of economic importances in livestock breeding, because they affect the profitability of animal production. The phenotypic expression of these traits is controlled by multiple genes (polygenes), such as myostatin (MSTN) gene. This paper aims to discuss the expression, polymorphism and potential application of MSTN gene as a marker-assisted selection (MAS) for growth and carcass traits in beef cattle based on data from published studies. MSTN gene or known as growth and differentiation factor 8 (GDF8) is a member of the transforming growth factor-β (TGF-β) superfamily, which acts as a negative regulator of skeletal muscle mass deposition. Several published studies showed that mutations in the MSTN gene can inhibit the activation of myostatin, which leads to an increased muscle mass (hypertrophy). Several <em>MSTN</em> gene polymorphisms were reported to be associated with growth and carcass traits in local cattle in several countries, including Indonesia, namely Bali cattle. Based on several assumptions: 1) there is MTSN gene polymorphisms in a population, 2) there is a significant association between MSTN gene polymorphisms and growth and carcass traits, as reported in several beef cattle populations and 3) those cattle with superior genotype have better growth performances, we expect that there will be improvement in growth performances in the future if those cattle are selected. Understanding MSTN gene polymorphisms would be useful to make strategies for the genetic improvement for growth and carcass traits of local cattle.</p>

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Section: Polmorfisme Gen Myostatin Dan Asosiasinya Terhadap Sifat Pertumbuhan Dan Karkasunclassified

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Myostatin Gene as a Genetic Marker for Growth and Carcass Traits in Beef Cattle

Prihandini¹,

Hariyono

Tribudi

2021

WARTAZOA

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“…European cattle breeds with heterozygous genotype variations, such as Limousine, exhibited better meat quality and growth performance than homozygous genotypes. However, it has been established that MSTN gene polymorphism and its association with growth traits in European cattle breeds [ 37 ], Angus cattle [ 11 , 12 ], Belgian Blue cattle [ 26 ], and Nellore cattle [ 25 , 27 ] and the association between the MSTN gene polymorphism and growth traits in SO cattle, one of the Bos indicus breed, have not been studied in depth. To date, the MSTN gene is considered polymorphic in other Ongole crossbred cattle, such as PO cattle, Bengali, or Zebu cattle ( B. indicus ) [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Gaina¹,

Amalo²

2022

J Adv Vet Anim Res

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Objective: As one of the most valuable genetic resources of Ongole beef cattle globally, the Sumba Ongole (SO) cattle population is being studied in this investigation of myostatin (MSTN) gene polymorphism and its association with growth traits. Materials and Methods: Blood samples from 161 SO cattle were collected and analyzed. Deoxyribonucleic acid (DNA) was isolated. The DNA was electrophoresed and extracted, and finally, the annealing temperature was optimized, followed by amplification and sequencing. Next, we used a Basic local alignment search tool to assess the sequencing data. Results: The analysis revealed 22 single nucleotide polymorphisms (SNPs) in the MSTN gene in this region that showed genetic variation. Two SNPs, c.424 G > A, and c.467 G > C, were found to be significantly associated with SO cattle phenotypes of wither height, heart girth, and hip height (p < 0.05) but not with body weight or body length (p > 0.05). Conclusion: As a result of our findings, the MSTN gene polymorphism and its correlation with growth traits in SO cattle may be employed as a candidate marker in SO cattle and other beef cattle breeds.

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“…The significant effect of FASN gene polymorphisms was also confirmed by other authors [ 10 ]. Additionally, other gene polymorphisms were studied in relation to the FA profile, for example, GH ( growth hormone ), MSTN ( myostatin ), FADS2 ( fatty acid desaturase 2 ), CPM ( carboxypeptidase ), THRSP ( thyroid hormone-inducible hepatic protein ), ACACA ( acetyl-CoA carboxylase alpha ), AGPAT3 ( 1-acylglycerol-3-phosphate O-acyltransferase 3 ) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The authors suggest that some of them could be useful as a marker selection for FA composition in milk.…”

Section: Introductionmentioning

confidence: 99%

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Samková

Čítek

Brzáková

et al. 2021

Animals

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This study aimed to analyze the factors affecting the fatty acid (FA) profile in cow’s milk. The effects of a farm, lactation parity and stage, breed and polymorphisms in the AGPAT6, DGAT1, LEP, FASN and SCD1 genes were evaluated. A total of 196 Holstein cows, 226 Simmental cows and seven crosses were sampled 751 times. The cows were kept at five farms and were in the first up to the sixth lactation, and 49 individual FAs and 11 groups were analyzed. The farm significantly affected the proportion of all FAs except for C16:1n-7c and isoC14:0. Additionally, the lactation stage was significant for most FAs, and the opposite was true for lactation parity. The effect of the breed was negligible. For the gene polymorphisms, the SCD1 TT genotype exceeded the CC in C10:0, C12:0, C14:0, C16:1n-7c and C18:2, and the opposite was true for C10:1, C12:1, C14:1n-5c, isoC17:0, C16:1 and C18:1, i.e., the TT genotype was higher for saturated FAs, and the CT genotype was higher for monounsaturated FAs. The results hint at the intermediary heredity of the SCD1 gene. The FASN gene was strongly associated with four FAs and branched-chain FAs, and genotype AG was better than GG. LEP was significant for five individual FAs and branched-chain FAs. The differences in FA composition among genotypes were rather small, which could lead to overestimation of the effect and needs to be considered in the next research.

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Associations between the Bovine Myostatin Gene and Milk Fatty Acid Composition in New Zealand Holstein-Friesian × Jersey-Cross Cows

Cited by 7 publications

References 31 publications

Myostatin Gene as a Genetic Marker for Growth and Carcass Traits in Beef Cattle

Myostatin Gene as a Genetic Marker for Growth and Carcass Traits in Beef Cattle

Genetic polymorphism of myostatin gene in Sumba Ongole (Bos indicus) cattle and its association with growth traits

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

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