Associations between XRCC1 Gene Polymorphisms and Coronary Artery Disease: A Meta-Analysis

Ma, Wen-Qi; Han, Xi‐Qiong; Wang, Xin; Wang, Ying; Zhu, Yi; Liu, Naifeng

doi:10.1371/journal.pone.0166961

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…Secondly, environmental factors may also affect relationship between PAI‐1 rs1799889 A/G polymorphism and PAI. Unfortunately, the majority of eligible publications only focused on genetic associations, so we could not estimate genetic‐environmental interactions in this meta‐analysis . Thirdly, this meta‐analysis was designed to assess associations between all PAI‐1 polymorphisms and VTE.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the majority of eligible publications only focused on genetic associations, so we could not estimate genetic-environmental interactions in this meta-analysis. 19 Thirdly, this meta-analysis was designed to assess associations between all PAI-1 polymorphisms and VTE. Nevertheless, only rs1799889 polymorphism was analyzed by us because no any other PAI-1 polymorphisms were studied by at least two different studies.…”

Section: Discussionmentioning

confidence: 99%

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Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

Huang

Wang

et al. 2019

Clinical Cardiology

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BackgroundAssociation between plasminogen activator inhibitor‐1 (PAI‐1) rs1799889 polymorphism and venous thromboembolism (VTE) were explored by many previous studies, yet the findings of these studies were conflicting.Hypothesis PAI‐1 rs1799889 polymorphism may serve as a genetic marker of VTE. We aimed to better clarify the relationship between PAI‐1 rs1799889 polymorphism and VTE in a larger combined population by performing a meta‐analysis.MethodsLiteratures were searched in Pubmed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI). We used Review Manager to combine the results of individual studies.ResultsForty‐eight studies involving 14 806 participants were eligible for inclusion. Combined results revealed that PAI‐1 rs1799889 polymorphism was significantly associated with VTE in Caucasians (dominant comparison: odds ratio [OR] 1.20, 95% confidence interval [CI] 1.09‐1.32; recessive comparison: OR 0.84, 95% CI 0.76‐0.94; allele comparison: OR 1.08, 95% CI 1.02‐1.15) and East Asians (dominant comparison: OR 1.60, 95% CI 1.17‐2.19; allele comparison: OR 1.53, 95% CI 1.21‐1.93). Further analyses obtained similar significant associations in these with deep vein thrombosis (DVT) and these with Factor V Leiden mutation.ConclusionsOur findings supported that PAI‐1 rs1799889 polymorphism may serve as one of the predisposing factors of VTE in both Caucasians and East Asians, especially in these with DVT and these with Factor V Leiden mutation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

Huang

Wang

et al. 2019

Clinical Cardiology

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“…Firstly, our integrated analyses results were derived from unadjusted pooling of previous studies. Without access to raw data of eligible studies, we can only assess associations between GST null polymorphisms and the risk of CAD based on re-calculations of raw genotypic frequencies provided by eligible studies, and we need to admit that lack of further adjustment for baseline characteristics such as age, gender or co-morbid conditions may possibly influence reliability of our findings [21]. Secondly, environmental factors such as smoking status, eating habits or exercise levels may also influence associations between polymorphisms in GST null polymorphisms and the risk of CAD.…”

Section: Discussionmentioning

confidence: 99%

GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis

Cao

et al. 2020

Thrombosis J

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Background: Whether glutathione S-transferase (GST) null polymorphisms, namely GSTM1 null, GSTP1 null and GSTT1 null polymorphisms, influence the risk of coronary artery disease (CAD) or not remains unclear. Thus, the authors performed a meta-analysis to more robustly estimate associations between GST null polymorphisms and the risk of CAD by integrating the results of previous publications. Methods: Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible studies, and 45 genetic association studies were finally selected to be included in this meta-analysis. Results: We found that GSTM1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.37, p = 0.003) and mixed population (OR = 1.61, p = 0.004), GSTP1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23, p = 0.03), whereas GSTT1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23, p = 0.02), Caucasians (OR = 1.23, p = 0.02) and East Asians (OR = 1.38, p < 0.0001). Conclusions: This meta-analysis demonstrated that GSTM1 null, GSTP1 null and GSTT1 null polymorphisms were all significantly associated with an increased risk of CAD.

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“…The current meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist [ 20 – 22 ].…”

Section: Methodsmentioning

confidence: 99%

Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis

Zhang

Cao

Zhang

et al. 2019

BMC Cardiovasc Disord

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BackgroundWhether adiponectin (ADIPOQ) polymorphisms are associated with coronary artery disease (CAD) remain controversial. Therefore, we performed this meta-analysis to better explore potential roles of ADIPOQ polymorphisms in CAD.MethodsPubMed, Web of Science, Embase and CNKI were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsTotally 45 studies were included for pooled analyses. A significant association with the susceptibility to CAD was detected for rs2241766 (dominant model: p = 0.0009, OR = 0.82, 95%CI 0.73–0.92; recessive model: p = 0.04, OR = 1.29, 95%CI 1.02–1.64; allele model: p < 0.0001, OR = 0.80, 95%CI 0.73–0.88) polymorphism in overall population. Further subgroup analyses by ethnicity showed that rs1501299 polymorphism was significantly associated with the susceptibility to CAD in East Asians, whereas rs2241766 polymorphism was significantly associated with the susceptibility to CAD in Caucasians, East Asians and South Asians.ConclusionsOur findings indicated that rs1501299 and rs2241766 polymorphisms both affect the susceptibility to CAD in certain populations.

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Associations between XRCC1 Gene Polymorphisms and Coronary Artery Disease: A Meta-Analysis

Cited by 9 publications

References 31 publications

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis

Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis

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