2008
DOI: 10.1016/j.cardfail.2007.10.015
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Atorvastatin Attenuates Cardiomyocyte Loss in Adult Rats From Protein-Restricted Dams

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Cited by 19 publications
(11 citation statements)
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“…These findings support the importance of nitrogen for healthy development and growth of the fetus. Similar results have been obtained in rats fed a low-protein diet by various other treatments, like perinatal administration of folate [113], metyrapone (11β-​hydroxylase inhibitor) [114] or lazaroid (an inhibitor of lipid peroxidation) [115], as well as postnatal treatment with fish oil (ω-3 polyunsaturated fatty acids) [116] or atorvastatin (cholesterol-lowering and anti-atherosclerotic drug) [117]. …”
Section: Proposed Mechanistic Pathways Of Iugrsupporting
confidence: 70%
“…These findings support the importance of nitrogen for healthy development and growth of the fetus. Similar results have been obtained in rats fed a low-protein diet by various other treatments, like perinatal administration of folate [113], metyrapone (11β-​hydroxylase inhibitor) [114] or lazaroid (an inhibitor of lipid peroxidation) [115], as well as postnatal treatment with fish oil (ω-3 polyunsaturated fatty acids) [116] or atorvastatin (cholesterol-lowering and anti-atherosclerotic drug) [117]. …”
Section: Proposed Mechanistic Pathways Of Iugrsupporting
confidence: 70%
“…The stereological parameter of collagen volume density (Vv) was estimated from the remote region by point counting for collagen according to the following formula: Vv[collagen]  =  PP[collagen]/72; where PP is the number of points that hit the structure and 72 is the total number of test points. A points test system was used for analysis in a standard test area of 0.15 mm 2 (21). …”
Section: Methodsmentioning
confidence: 99%
“…Maternal protein restriction impairs various organ functions due to an important reduction of functional cells such as beta cells in pancreas (Boujendar et al, 2002), glomeruli in kidney (Villar-Martini et al, 2009), and cardiomyocytes in heart (Bezerra et al, 2008). Therefore, it programs to Type 2 diabetes, hypertension, and heart failure later in life.…”
Section: Discussionmentioning
confidence: 99%