Atrovirisidone B, a New Prenylated Depsidone with Cytotoxic Property from the Roots of Garcinia atroviridis

Permana, Dharma; Abas, Faridah; Maulidiani, M.; Shaari, Khozirah; Stanslas, Johnson; Ali, Abdul Manaf; Lajis, Nordin Hj

doi:10.1515/znc-2005-7-802

Cited by 22 publications

(14 citation statements)

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“…Previous studies have reported the isolation of flavonoids such as naringenin, binarigenin, morelloflavone and fukugiside from G. atroviridis . In addition, other phenolic compounds such as xanthone (atroviridin), benzoquinone (atrovirinone), depsidone (atrovirisdone and atrovirisdone B), hydroquinone (4‐methylhydroatrovirinone), cambogin, garcinol, camboginal and isogarcinol were also found in G. atroviridis . The present study found that the polyphenolic compounds in the methanolic extract of G. atroviridis leaves and ripe fruit rind are mostly made up of flavonoids, whereas for the methanol extracts of other parts they are made up of a mixture of flavonoid and non‐flavonoid phenolic compounds.…”

Section: Resultsmentioning

confidence: 50%

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

2013

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Aqueous and methanol extracts of G. atroviridis showed higher antihyperlipidemic and antioxidant effects, respectively. Total phenolic and flavonoid contents showed significant correlations with antioxidant but not with antihyperlipidemic activities, indicating the involvement of other compounds. Contrary to the traditional belief, the present findings suggest that the fruit has higher antihyperlipidemic potential than the fruit rind.

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Section: Resultsmentioning

confidence: 50%

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

2013

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“…These metabolites were identified by analysing their spectroscopic data and comparing them with the literature data. Compounds (3) and (4) have been isolated previously from G. travancoria [10], while compound (2) from G. atroviridis [11]. Besides, compound (5) has been reported previously from G. cowa [12].…”

Section: Resultsmentioning

confidence: 90%

Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Salleh¹,

Sazali²,

Ahmad³

et al. 2017

mpj

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The phytochemical and biological activity of the leaves and stem barks of Garcinia griffithii have been investigated. Extraction and chromatographic purification of the leaves and stem barks extracts have successfully afforded five biflavonoids namely amento-4''-methylether (1), 3,8''-binaringenin (2), morelloflavone (3), 3,8''-binaringenin-7''-O-glucoside (4) and morelloflavone-7''-Oglucoside (5), together with squalene (6), canophyllol (7), friedelin (8) and β-amyrin (9) which were characterized spectroscopically.All extracts and phytochemicals were tested for antioxidant, antityrosinase and antibacterial activities. The antioxidant assay on DPPH radical scavenging showed that the n-hexane extract of the stem barks had the highest radical scavenging activity with IC 50 value of 96.4 μg/mL, while compound (3) was found to be the strongest antioxidant compound with IC 50 value of 57.6 μg/mL. The methanol extract of the leaves showed the highest total phenolic content with 444.1 mg/g of gallic acid equivalent (GAE/L) and 423.1 mg/g of cathechin equivalent (CE/L). The extracts and all compounds were found to have weak antityrosinase activity. The antimicrobial assays of all the extracts were carried out by minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC). The methanol extract of the leaves showed the most significant antimicrobial activity towards E. faecalis and K. pneumoniae with MIC and MBC value ranged between 225-450 μg/mL compared to the other extracts.

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“…The fruit rind is used in rickets and enlargement of spleen and to heal bone fractures [13]. In Southeast Asian folkloric medicine, a decoction of G. atroviridis (leaves and roots) is sometimes used for the treatment of cough, dandruff, earache, stomach pains associated with pregnancy, and throat irritation [49]. The dried fruit of G. atroviridis is used for improving blood circulation, for the treatment of coughs, as a laxative, and as a expectorant.…”

Section: Uses In Traditional Medical Systemsmentioning

confidence: 99%

Updates on Antiobesity Effect ofGarciniaOrigin (−)-HCA

Chuah¹,

Beh

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Garcinia is a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)-hydroxycitric acid has been identified as a potential supplement for weight management and as antiobesity agent. Various in vivo studies have contributed to the understanding of the anti-obesity effects of Garcinia/hydroxycitric acid via regulation of serotonin level and glucose uptake. Besides, it also helps to enhance fat oxidation while reducing de novo lipogenesis. However, results from clinical studies showed both negative and positive antiobesity effects of Garcinia/hydroxycitric acid. This review was prepared to summarise the update of chemical constituents, significance of in vivo/clinical anti-obesity effects, and the importance of the current market potential of Garcinia/hydroxycitric acid.

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Atrovirisidone B, a New Prenylated Depsidone with Cytotoxic Property from the Roots of Garcinia atroviridis

Cited by 22 publications

References 0 publications

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

Effect of extraction solvents and plant parts used on the antihyperlipidemic and antioxidant effects ofGarcinia atroviridis: a comparative study

Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

Updates on Antiobesity Effect ofGarciniaOrigin (−)-HCA

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