Atypical plasma lipid profile in cancer patients: Cause or consequence?

Munir, Rimsha; Usman, Hina; Hasnain, Shahida; Smans, Karine; Kalbacher, Hubert; Zaidi, Nousheen

doi:10.1016/j.biochi.2014.03.010

Cited by 39 publications

(27 citation statements)

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“…Despite these efforts the previous reports fail to provide us with consistent and peculiar trends that could be associated with plasma lipid profiles of the leukemia patients [9]. These inconsistencies in the literature are often attributed to various limitations of the previous works [9]. Most of these studies have overlooked the confounding effects of related risk-factors including gender, age and BMI [1][2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies have attempted to outline the peculiar features of the lipid profiles in these patients [9]. Despite these efforts the previous reports fail to provide us with consistent and peculiar trends that could be associated with plasma lipid profiles of the leukemia patients [9]. These inconsistencies in the literature are often attributed to various limitations of the previous works [9].…”

Section: Discussionmentioning

confidence: 93%

“…Most of the previous reports have demonstrated a decrease in total cholesterol (TC) [1][2][3][4][5][6] and various lipoprotein subfractions particularly, high-density lipoprotein cholesterol (HDL-C) [1][2][3][4][5][6][7][8], whereas an increase in the serum triglyceride (TG) concentrations of the leukemia patients is also a frequently observed phenomenon [1,3,4,[6][7][8]. Nevertheless there are several inconsistencies in the previous reports [9]. For instance it has been reported that though the TC concentrations in leukemia patients are higher than the control group, this difference is not statistically significant [1].…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Revisiting the dyslipidemia associated with acute leukemia

Usman

Rashid

Ameer

et al. 2015

Clinica Chimica Acta

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Revisiting the dyslipidemia associated with acute leukemia

Usman

Rashid

Ameer

et al. 2015

Clinica Chimica Acta

Self Cite

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“…Lipid metabolism is an emerging field in cancer research, and there is increasing evidence that lipid biomarkers should be considered a crucial hallmark of cancer . Recently, the Raman‐based approach has gained exciting new perspectives for better understanding of the role of lipid droplets (LDs) in health and diseases . LDs typically consist of neutral lipids in the form of triacylglycerols, cholesteryl esters or retinyl esters surrounded by a phospholipid monolayer and proteins at the surface of LDs.…”

Section: Discussionmentioning

confidence: 99%

“…[39][40][41] Recently, the Raman-based approach has gained exciting new perspectives for better understanding of the role of lipid droplets (LDs) in health and diseases. [41][42][43][44] LDs typically consist of neutral lipids in the form of triacylglycerols, cholesteryl esters or retinyl esters surrounded by a phospholipid monolayer and proteins at the surface of LDs. In the present study, the weak Raman band observed at 1740 cm À1 appears only in the control tissues (group II) and is caused by changes in the C¼O stretching vibration of triglycerides and cholesterol esters.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Raman spectroscopy for prediction of antitumor response to silibinin and its nanoparticulates in DMBA‐induced oral carcinogenesis

Gohulkumar

Kumar

Krishna

et al. 2016

J Raman Spectroscopy

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Raman spectroscopy is a vibrational spectroscopic technique that can be used to monitor the therapeutic efficacy of anticancer drugs during carcinogenesis in a non‐invasive and label‐free manner. The present study aims to investigate the biochemical changes exerted upon free silibinin (SIL) and its nanoparticulate (SILNPs) treatment against 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced oral carcinogenesis in the fingerprint region of 1800–500 cm−1 using HE‐785 Raman spectrometer. Raman spectra differed significantly between the control and tumor tissues, with tumor tissues characterized by increased intensities of vibrational bands such as nucleic acids, phenylalanine and tryptophan and a lower percentage of lipids when compared to the control tissues. Further, oral administration of free SIL and SILNPs significantly increased lipids and decreased the levels of tryptophan, phenylalanine and nucleic acid contents. Overall, the treatment of nanoparticulate SIL was found to be a more potent antitumor effect than free SIL in preventing the formation of tumor and also brought back the several Raman bands to a normal range in the buccal mucosa of hamsters during DMBA‐induced oral carcinogenesis. In addition, the detailed secondary structure of proteins in the control and experimental groups is also presented. Furthermore, the diagnostic algorithms based on principal component linear discriminant analysis (PC‐LDA) achieved an overall sensitivity of 94–100% and specificity of 76–100%. These results further demonstrate that Raman spectroscopy associated with PC‐LDA diagnostic algorithms could be a valuable tool for rapid and sensitive detection of specific biomolecular changes at the molecular level in response to anticancer drug. Copyright © 2015 John Wiley & Sons, Ltd.

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Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

Qahremani,

Rabizadeh,

Mirmiranpoor

et al. 2023

Health Science Reports

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Background and AimThe role of lecithin: cholesterol acyltransferase (LCAT) and oxidized low‐density lipoprotein (ox‐LDL) in endometrial cancer (EC) or EC with concurrent type 2 diabetes is still unclear. This study investigated the LCAT activity, ox‐LDL, and lipid profile in EC patients with or without type 2 diabetes and compared them with healthy individuals and patients with type 2 diabetes alone.MethodsIn this cross‐sectional, case–control study, 93 female participants were recruited. The participants were divided into four groups, including EC with type 2 diabetes (n = 19), EC without type 2 diabetes (n = 17), type 2 diabetes (n = 31), and healthy controls (n = 26). Sociodemographic information, the LCAT activity, triglyceride (TG), total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and ox‐LDL levels were collected. One‐way analysis of variance and analysis of covariance, Student's t‐test, Mann–Whitney U‐test, and χ2‐test were used to compare demographic features and laboratory results among studied groups. Regression analyses were also performed to evaluate the interaction effect between EC and type 2 diabetes on serum LCAT activity.ResultsThe LCAT activity was significantly lower, and ox‐LDL levels were significantly higher in all patient groups compared to the healthy controls (p < 0.001). EC patients had significantly lower LCAT activity and higher ox‐LDL levels than type 2 diabetes and healthy groups (p < 0.05). Higher levels of TG and lower levels of HDL‐C were observed in all patient groups compared to the healthy group (all p < 0.001). Patients with EC and concomitant type 2 diabetes had significantly lower serum LDL‐C levels than healthy and type 2 diabetes groups (p < 0.05).ConclusionsThe combination of EC and type 2 diabetes had a subadditive effect on LCAT activity and ox‐LDL level. The lowest LCAT activity and the highest ox‐LDL levels were observed in patients with EC and concurrent type 2 diabetes.

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Atypical plasma lipid profile in cancer patients: Cause or consequence?

Cited by 39 publications

References 100 publications

Revisiting the dyslipidemia associated with acute leukemia

Revisiting the dyslipidemia associated with acute leukemia

Evaluation of Raman spectroscopy for prediction of antitumor response to silibinin and its nanoparticulates in DMBA‐induced oral carcinogenesis

Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

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