Author Correction: Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

Pizato, Nathalia; Luzete, Beatriz Christina; Kiffer, Larissa Fernanda Melo Vasconcelos; Corrêa, Luís Henrique; Santos, Igor de Oliveira; Assumpção, José Antônio Fagundes; Ito, Marina; Magalhães, Kelly Grace

doi:10.1038/s41598-018-27850-y

Cited by 12 publications

(8 citation statements)

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“…Pyroptosis is a new cell death mediated by proteases activated within inflammasomes. It is also a prominent target to mediate anti-tumour treatments [24]. In ALA loaded lipid/ PLGA MBs mediated SDT, we also observed pyroptosis in AsPC-1 and BxPC-3 cells.…”

Section: Discussionsupporting

confidence: 52%

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5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells

Yang

Liu

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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5-Aminolevulinic acid hydrochloride (ALA)-mediated sonodynamic therapy (SDT) had anti-tumour effect on pancreatic cancer cells. Hence, ALA loaded lipid/poly(lactic-co-glycolic acid) (PLGA) microbubbles (MBs)-mediated SDT for pancreatic cancer has great potential. The average size of ALA-lipid MBs and ALA-PLGA MBs was about 3.0 mm. The two kinds of MBs had good biocompatibility to normal HPDE6-C7 cells and were not toxic to pancreatic cancer cells. Compared with ALA-induced SDT, a statistically significant decrease in cell viability was observed in ALA lipid/PLGA MBs combined with ultrasound groups in AsPC-1 and BxPC-3 cells (p < .05). Obvious effect on the apoptotic rate, apoptosis and pyroptosis morphology, enhanced reactive oxygen species was found in ALA-lipid/PLGA MBs mediated SDT in vitro. Through in vivo study, we found ALA-lipid/PLGA MBs-mediated SDT was a promise treatment for pancreatic cancer.

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Section: Discussionsupporting

confidence: 52%

“…In ALA loaded lipid/ PLGA MBs mediated SDT, we also observed pyroptosis in AsPC-1 and BxPC-3 cells. Pore formation in cell membrane is the most important event in pyroptosis [24]. In the ALA loaded lipid/PLGA MBs mediated SDT group, the MBs destruction and cavitation may take part in the membrane pore formation in pyroptosis.…”

Section: Discussionmentioning

confidence: 99%

5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells

Yang

Liu

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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“…9). Subsequently, an increasing number of chemical target drugs, reagents, and natural products have been found to cause pyroptosis in various types of cancers, many of which imbue antitumor effects [234][235][236][237][238][239][240][241] (Table 2).…”

Section: Chemotherapymentioning

confidence: 99%

Role of pyroptosis in inflammation and cancer

et al. 2022

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Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses. Pyroptosis, an innate immune response, can be triggered by the activation of inflammasomes by various influencing factors. Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11, both of which cleave gasdermin D to release its N-terminal domain, which can bind membrane lipids and perforate the cell membrane. Here, we review the latest advancements in research on the mechanisms of pyroptosis, newly discovered influencing factors, antitumoral properties, and applications in various diseases. Moreover, this review also provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and finally challenges and future directions in the field.

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“…Recent studies have revealed the roles of pyroptosis in several types of cancers, including colon cancer, gastric cancer, lung cancer, breast cancer, liver cancer, and glioma. However, no studies have focused on the pyroptosis in PDAC (18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis

Cui

Zhou

Yang

et al. 2019

Molecular Cancer Research

108

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Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, and its incidence is increasing annually. It is critical to reveal and delineate the molecular mechanism promoting PDAC development and progression. Mammalian STE20-like kinase 1 (MST1) is a proapoptotic cytoplasmic kinase and also one of the core components of the Hippo pathway. Here, we showed that MST1 expression was decreased in PDAC, and restored expression of MST1 promoted PDAC cell death and suppressed the proliferation, migration, invasion, and cell spheroid formation of PDAC via caspase-1-induced pyroptosis. Further studies demonstrated that pyroptosis induced by MST1 was independent of the Hippo pathway, but mediated by reactive oxygen species (ROS). And ROS scavenger N-acetyl-cysteine attenuated the activation of caspase-1 induced by MST1 and the effect of MST1 in PDAC cell death, proliferation, migration, and invasion. Collectively, our study demonstrated that MST1 suppressed the progression of PDAC cells at least partly through ROS-induced pyroptosis.Implications: In this study, we identified a new mechanism of MST1 in inhibiting PDAC development and progression and revealed that MST1 would be a potential prognostic and therapeutic target for PDAC.

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Author Correction: Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Cited by 12 publications

References 0 publications

5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells

5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells

Role of pyroptosis in inflammation and cancer

MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis

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