Autocrine/Paracrine Platelet-Derived Growth Factor Regulates Proliferation of Neural Progenitor Cells

Erlandsson, Anna; Brännvall, Karin; Gústafsdóttir, Sigrún M.; Westermark, Bengt; Forsberg-Nilsson, Karin

doi:10.1158/0008-5472.can-06-0900

Cited by 60 publications

(60 citation statements)

References 33 publications

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“…Signaling through this receptor is critical for important events that dictate the fate of gonocytes, the precursors of the SSC, including resumption of proliferation, inhibition of apoptosis, and migration. Analogously to what was reported in neurons (52), PDGFR activation could act as a mitogen in the early phase of stem cell differentiation to expand the pool of immature gonocytes. Furthermore, PDGFR-␤ could stimulate the differentiation of gonocytes toward SSC.…”

Section: Discussionsupporting

confidence: 56%

Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes

et al. 2008

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Section: Discussionsupporting

confidence: 56%

Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes

et al. 2008

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“…Next we investigated whether estrogens would modulate the effect of PDGF, a mitogen for oligodendrocyte precursor cells (3). We found that the number of NG2-positive cell was 42 ± 3.0% in the presence of PDGF (Fig.…”

Section: Effect Of E2 or Bpa On Differentiation Of Nscsmentioning

confidence: 96%

Effects of estrogens on proliferation and differentiation of neural stem/progenitor cells

et al. 2008

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We investigated the effect of the female hormone 17β-estradiol (E2) and the hormone mimic bisphenol A (BPA) on the proliferation and differentiation of rat neural stem/progenitors cells (NS/ PCs) cultured from the telencephalon of embryonic day-15 rats. Basic fibroblast growth factor (FGF-2) is a potent mitogen of early generated NS/PCs, and is used for the proliferation of NS/ PCs in vitro. Administration of E2 or BPA alone to the NS/PCs stimulated their proliferation in the absence but not in the presence of FGF-2. E2-or BPA-treatment increased the ratio of the oligodendrocytes generated from the NS/PCs to total cells; however, this ratio did not change when the cells were stimulated with platelet-derived growth factor (PDGF), a mitogen for oligodendrocyte precursors, or with neurotrophin-3, an oligogenic factor for glial progenitor cells. These results suggest that estrogens would influence the fate of NS/PCs when the cells are poorly supplied with mitogens or differentiation factors during the early stages of neurogenesis.

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“…Recent in vitro studies on the effects of PDGF signaling on neural stem/progenitor cell differentiation also demonstrate a growth-promoting effect on progenitor cells and an inhibition of differentiation [Erlandsson et al, 2006]. Exposure to PDGF in the first half of the differentiation paradigm resulted in a delay in both neuron and oligodendrocyte differentiation.…”

Section: Pdgfr ␣ -Expressing Astrocytes In the Svz Are Primary Progenmentioning

confidence: 99%

Characterization of Adult Neural Stem Cells and Their Relation to Brain Tumors

Jackson

Alvarez-Buylla²

2008

Cells Tissues Organs

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The adult mammalian brain contains neural stem cells that are capable of generating new neurons and glia over the course of a lifetime. Neural stem cells reside in 2 germinal niches, the subventricular zone (SVZ) and the dentate gyrus subgranular zone. These primary progenitors have been identified in their niche in vivo; these cells have characteristics of astrocytes. Recent studies have shown that adult SVZ stem cells are derived from radial glia, the stem cells in the developing brain, which in turn are derived from the neuroepithelum, the earliest brain progenitors. Thus, SVZ stem cells are a continuum from neuroepithelium to radial glia to astrocytes, and are contained within what has been considered the lineage for astrocytes. However, it seems that only a small subset of the astrocytes present in the adult brain have stem cell properties. Recent findings have shown that SVZ stem cell astrocytes express a receptor for platelet-derived growth factor (PDGF), suggesting that the ability to respond to specific growth factor stimuli, such as PDGF, epidermal growth factor and others, may be unique to these stem cell astrocytes. Intriguingly, activation of these same signaling pathways is widely implicated in brain tumor formation. Since the adult brain has very few proliferating cells capable of accumulating the numerous mutations required for transformation, the adult neural stem and/or progenitor cells may be likely candidates for the brain tumor cell of origin. Indeed, activation of the PDGF or epidermal growth factor pathways in adult neural stem or progenitor cells confers tumor-like properties on these cells, lending support to this hypothesis.

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Autocrine/Paracrine Platelet-Derived Growth Factor Regulates Proliferation of Neural Progenitor Cells

Cited by 60 publications

References 33 publications

Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes

Platelet-Derived Growth Factor Receptor β-Subtype Regulates Proliferation and Migration of Gonocytes

Effects of estrogens on proliferation and differentiation of neural stem/progenitor cells

Characterization of Adult Neural Stem Cells and Their Relation to Brain Tumors

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