Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography

Finke, Markus; Kantelhardt, Sven R.; Schlaefer, Alexander; Bruder, Ralf; Lankenau, Eva; Giese, Alf; Schweikard, Achim

doi:10.1002/rcs.1425

Cited by 50 publications

(34 citation statements)

References 22 publications

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“…The use of fluorescent markers is challenging due to potential toxicity, biological side effects and 'low' specificity [21]. As a result of its technical nature, OCT is a non-real-time scanning technique which is best suitable for relatively small areas [22]. Despite these developments, a real-time non-invasive and specific technique for nerve identification is still not available.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of collimated polarized light imaging for real-time intraoperative selective nerve identification in the human hand

Chin¹,

Engelsman²,

Chin³

et al. 2017

Biomed. Opt. Express

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Abstract:Intraoperative peripheral nerve lesions are common complications due to misidentification and limitations of surgical nerve identification. This study validates a realtime non-invasive intraoperative method of nerve identification. Long working distance collimated polarized light imaging (CPLi) was used to identify peripheral radial nerve branches in a human cadaver hand by their nerve specific anisotropic optical reflection. Seven ex situ and six in situ samples were examined for nerves, resulting after histological validation, in a 100% positive correct score (CPLi) versus 77% (surgeon). Nerves were visible during a clinical in vivo observation using CPLi. Therefore CPLi is a promising technique for intraoperative nerve identification. for high resolution fat-suppressed imaging of the brachial and lumbosacral plexuses," Eur.

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Section: Introductionmentioning

confidence: 99%

Evaluation of collimated polarized light imaging for real-time intraoperative selective nerve identification in the human hand

Chin¹,

Engelsman²,

Chin³

et al. 2017

Biomed. Opt. Express

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“…For giving an intuitive view of brain tissue, some researchers have designed and manufactured a neurosurgical probe of OCT, including endoscopic, needle-type, hand-held probe, and other kinds of neurosurgical OCT robotic arms (68,(72)(73)(74)(75)(76)(77)(78)(79) intrinsic brain tumors (68). In microsurgery, Kang et al proposed a common-path OCT system with an applicable fiber-optic endoscopic probe (74,76).…”

Section: Neurosurgical Guidance With Intraoperative Oct Imaging and Imentioning

confidence: 99%

“…Some novel techniques may assist surgeons to achieve micrometer precision incisions, reducing the risks of damage to the surrounding tissue, and minimizing intraoperative complications (92). Overlaying microscopy images with depth information from OCT could lead to improved detection of residual tumor cells (58,93). Combining OCT imaging with an operating microscope (94,95) can offer intuitionistic viewing of the surgical area.…”

Section: Neurosurgical Guidance With Intraoperative Oct Imaging and Imentioning

confidence: 99%

Optical coherence tomography for precision brain imaging, neurosurgical guidance and minimally invasive theranostics

Fan

Xia

Zhang

et al. 2018

BST

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“…For clinical use in neurosurgery, OcT can be integrated into surgical microscopes and neuroendoscopes [25][26][27]. The spatial resolution of OcT (unlike MPT) cannot provide subcellular visualization and differentiation between benign and malignant brain tumors.…”

Section: No4 65 сLinical Medicinementioning

confidence: 99%

Multiphoton Tomography and Cross-Polarization Optical Coherence Tomography for Diagnosing Brain Gliomas: Pilot Study

Dudenkova¹,

Yashin²,

Kiseleva³

et al. 2016

Sovrem Tehnol Med

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Progress in the surgery of infiltratively growing gliomas is closely related to intraoperative diagnostics. currently the most promising methods of optical imaging in the field of intraoperative identification of glioma boundaries and of grade of tumor are those providing high spatial resolution, such as optical coherence tomography (OcT) and multiphoton tomography (MPT). Nevertheless, for routine clinical use, evidence-based criteria are required. In this work the results of parallel ex vivo analysis of specimens of different grades of gliomas and of peritumoral areas obtained through the use of MPT and cross-polarization OcT (cP OcT) are compared with simultaneous histological descriptions and are presented in order to reveal the usefulness of each method in neurooncology.Key words: multiphoton tomography (MPT); cross-polarization optical coherence tomography (cP OcT); brain tumor rat model; glioma; glioblastoma; intraoperative diagnostics.For contacts: Konstantin S. Yashin, e-mail: jashinmed@gmail.com Gliomas constitute a considerable part (34%) of all intracranial tumors in people aged over 18 [1, 2]. Their distinctive feature is infiltrative growth into the surrounding white matter of the brain making it difficult to differentiate the boundary between the tumor and the brain tissue. According to the growth rate and the degree of invasion, astrocytic tumors are conditionally divided into slow-growing and fast-growing ones. The first group consists of pilocytic astrocytomas (Grade I) and diffuse astrocytomas (Grade II), while the latter types are anaplastic astrocytomas (Grade III) and glioblastomas (Grade IV) [3]. The higher the degree of malignancy, the more aggressive are both the tumor growth and the nature of invasion.

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Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography

Abstract: We demonstrated that it is possible to automatically acquire an OCT image of the complete resection cavity. Overlaying microscopy images with depth information from OCT could lead to improved detection of residual tumour cells.

Cited by 50 publications

References 22 publications

Evaluation of collimated polarized light imaging for real-time intraoperative selective nerve identification in the human hand

Evaluation of collimated polarized light imaging for real-time intraoperative selective nerve identification in the human hand

Optical coherence tomography for precision brain imaging, neurosurgical guidance and minimally invasive theranostics

Multiphoton Tomography and Cross-Polarization Optical Coherence Tomography for Diagnosing Brain Gliomas: Pilot Study

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