Avaliação da atividade leishmanicida do látex de Symphonia globulifera

Lopes, Ricardo Kind; Carvalho, Carlos Eduardo Garção de; Marques, Delcio Dias; Ferreira, Almecina Balbino; Almeida, Raquel M. de; Aguilar, Mariana Guerra de; Ferraz, Vany

doi:10.34117/bjdv6n4-005

Cited by 3 publications

(3 citation statements)

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“…In the study by David et al (2019) the researchers found for the latexes of Brosimum parinarioides and Parahancornia amapa the presence of the following phytochemical groups (alkaloids and derivatives of coumarins) and (organic acids, alkaloids, anthraquinones, depside & depsidones, and purines), respectively. Lopes et al (2020) they observed many phytochemical classes present in Symphonia globulifera latex such as saponins, reducing sugars, polysaccharides, phenolics, tannins, flavanones, flavanonols, catechins, xanthones, anthraquinones, depsides & depsidons and coumarins. Gallardo-Vásquez et al (2019) verified the presence of flavonoids, tannins, phenolic alkaloids, carbohydrates, steroids and triterpenes in the latex of J. curcas.…”

Section: Resultsmentioning

confidence: 99%

Triagem fitoquímica e atividade citotóxica do látex de Manilkara zapota (L.) P. Royen

et al. 2022

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Manilkara zapota espécie frutífera de áreas tropicais e neotropicais paresentam como produto do metabolismo especial o látex, com propriedades farmacológicas. Este estudo teve por objetivo avaliar a composição fitoquímica qualitativa e a atividade toxicológica sobre Artemia salina avaliado em diferentes concentrações do extrato coletado do pedicelo do fruto de M. zapota. O látex foi coletado e imediatamente, foi realizada a solubilidade em diferentes solventes polares e apolares, a prospecção fitoquímica utilizando diferentes reagentes e o ensaio de totoxicidade sobre larvas de A. salina em diferentes concentrações de látex. O látex apresentou resultado de solubilidade apenas para água e etanol. Foram observadas diversas classes fitoquímicas com resultados positivos em especial para flavonoides, fenólicos, esteroides e saponinas. O ensaio toxicológico sobre A. salina apresentou dose letal de 17.9 µg mL-1 considerada moderada. O látex de Manilkara zapota demonstrou grande aptidão para novos estudos quantitativos e de avaliação para outros modelos biológicos.

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Section: Resultsmentioning

confidence: 99%

Triagem fitoquímica e atividade citotóxica do látex de Manilkara zapota (L.) P. Royen

et al. 2022

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“…The advancement of the dissemination of multidrug-resistant bacterial strains has become a worldwide reality and is considered a serious public health problem as it affects not only the hospital community but also the community environment [12]. Reports of multidrug-resistant bacteria have been associated with contaminated environments such as urban rivers [13] and the use of antibiotics in agricultural practices [14]. In addition, within the context of a public health problem, leishmaniasis is neglected, occurring in underdeveloped countries with more vulnerable populations, thereby restricting access to quality health services [15].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Antibacterial, Antileishmanial, and Cytotoxic Potential of the Secondary Metabolites of Streptomyces sp. ARH (A3)

de Azevedo,

Rosa,

Dias

et al. 2024

Microorganisms

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This study aimed to evaluate the antibacterial, leishmanicidal, and cytotoxic potential of metabolites produced by bacteria isolated from rhizosphere soil samples. The bacterium was identified by genome sequencing as Streptomyces kronopolitis. A preliminary screening was carried out for the antimicrobial activity of S. kronopolitis, demonstrating activity against Staphylococcus aureus ATCC 6538, Corynebacterium diphtheriae ATCC 27010, C. diphtheriae ATCC 27012, and Mycobacterium abscessus, with inhibition halos of sizes 25, 36, 29, and 33 mm, respectively. To obtain secondary metabolites, the bacteria were subjected to submerged fermentation, and the metabolites were extracted using the liquid–liquid method with ethyl acetate. There was a similar MIC for M. abscessus and the two strains of C. diphtherium, reaching a concentration of 12.5 µg/mL, while that of S. aureus was 0.048 µg/mL. Assays for leishmanicidal activity and cytotoxicity against HEp-2 cells and red blood cells were performed. The metabolite showed an IC50 of 9.0 ± 0.9 µg/mL and CC50 of 221.2 ± 7.0 µg/mL. This metabolite does not have hemolytic activity and is more selective for parasites than for mammalian cells, with a selectivity index of 24.6. Thus, the studied metabolite may be a strong candidate for the development of less toxic drugs to treat diseases caused by pathogens.

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“…with contaminated environments such as urban rivers [11] and the use of antibiotics in agricultural practices [12]. In addition, within the context of a public health problem, leishmaniasis is considered to be neglected, occurring in underdeveloped countries with more vulnerable populations, thereby restricting access to quality health services [13]. Anthropozoonosis is a disease that affects approximately 88 countries and is endemic to Brazil [14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antibacterial, Antileishmanial, and Cytotoxic Potential of Secondary Metabolites of Streptomyces Kronopolitis

Rosa

Azevedo

Dias

et al. 2023

Preprint

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This study aimed to evaluate the antibacterial, leishmanicidal, and cytotoxic potential of metabolites produced by bacteria isolated from rhizosphere soil samples. The bacterium was identified by molecular techniques as Streptomyces kronopolitis. A preliminary screening was carried for the antimicrobial activity of S. kronopolitis, demonstrating activity against Staphylococcus aureus ATCC 6538, Corynebacterium diphtheriae ATCC 27010, C. diphtheriae ATCC 27012, and Mycobacterium abscessus, with inhibition halos of sizes 25, 36, 29, and 33 mm, respectively. To obtain secondary metabolites, the bacteria was subjected to submerged fermentation, and the metabolites were extracted using the liquid-liquid method with ethyl acetate. There was a similar MIC for M. abscessus and the two strains of C. diphtherium, reaching a concentration of 0.125 mg/mL, while that of S. aureus was 0.048 mg/mL. Assays for leishmanicidal activity and cytotoxicity against HEp-2 cells and red blood cells were performed. The metabolite showed IC50 of 9.0 ± 0.9 µg/mL and CC50 of 226.2 µg/ ml. This metabolite does not have hemolytic activity and is more selective for parasites than for mammalian cells, with a selectivity index of 24.85. Thus, the studied metabolite may be a strong candidate for the development of less-toxic drugs to treat diseases caused by pathogens.

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Avaliação da atividade leishmanicida do látex de Symphonia globulifera

Abstract: Avaliação da atividade leishmanicida do látex de Symphonia globulifera Evaluation of the leishmanicida activity of Symphonia globulifera latex

Cited by 3 publications

References 4 publications

Triagem fitoquímica e atividade citotóxica do látex de Manilkara zapota (L.) P. Royen

Triagem fitoquímica e atividade citotóxica do látex de Manilkara zapota (L.) P. Royen

An Evaluation of the Antibacterial, Antileishmanial, and Cytotoxic Potential of the Secondary Metabolites of Streptomyces sp. ARH (A3)

Evaluation of the Antibacterial, Antileishmanial, and Cytotoxic Potential of Secondary Metabolites of Streptomyces Kronopolitis

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