Avancées dans la physiopathologie de la pré-éclampsie : place de la réponse inflammatoire

Bretelle, Florence; Sabatier, Florence; Shojai, R.; Agostini, Aubert; Dignat-George, Françoise; Blanc, B.; D’ercole, C.

doi:10.1016/j.gyobfe.2003.12.015

Cited by 16 publications

(3 citation statements)

References 93 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of cardiovascular risk factors in SSA women is not negligeable. The median prevalences were: hypertension (29%), diabetes (7%), overweight (35%), obesity (11%), alcohol consumption (13%), tobacco (2%) [24][25][26]. Apart from tobacco, there is a significant prevalence of cardiovascular risk factors in SSA women.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of observational studies of the impact of cardiovascular risk factors on preeclampsia in sub-saharan Africa

Hounkpatin

Amidou

Houehanou

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Maternal mortality is a public health issue, particularly in low- and middle-income countries (LMIC). Sub-Saharan Africa (SSA) is the region most affected worldwide by maternal mortality, and preeclampsia is one of the main causes. We performed a systematic review of observational studies to identify the impact of cardiovascular risk factors on preeclampsia in SSA with a more representative sample. Methods Databases: PubMed and Google Scholar were searched to identify published studies. Studies were included if they reported results on the link between at least one cardiovascular risk factor and preeclampsia. Relevant studies quality was assessed with the Newcastle-Ottawa Scale (NOS). Odds ratios and relative risk (RR) were reported with their confidence intervals. Results Twelve articles (8 case-controls, 3 cohorts, 1 cross-sectional) were included in this review, with a total of 24,369 pregnant women. Cardiovascular risk factors such as chronic hypertension, overweight, obesity, diabetes and alcohol were significantly associated with a high risk of preeclampsia. Very few data were available concerning some risk factors. None of the articles reported tobacco consumption as a preeclampsia risk factor. There is a lack of data from French-speaking SSA countries. Conclusion Cardiovascular risk factors increase the risk of preeclampsia. Our results suggest the need for prospective cohort studies to ascertain this association in order to reduce maternal mortality due to preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

Systematic review of observational studies of the impact of cardiovascular risk factors on preeclampsia in sub-saharan Africa

Hounkpatin

Amidou

Houehanou

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Nutritional balance in pregnant women, such as food antioxidant intake and oxidative stress status in maternal, can cause IUGR. 42 IUGR often occurs in PE but the plasma levels of pregnant women influenced by vitamin C and E contents significantly increase live births with normal weight and length. 43 HSP-70 originates from ischemic and PE placenta that is oxidatively suppressed; it is regulated in pre-eclamptic placental tissue but not in normal placenta.…”

Section: Discussionmentioning

confidence: 99%

Study of Combination of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) Effects in the Expression of Malondialdehyde (MDA), Heat Shock Protein-70 (HSP70) and Placental Histology of Preeclamptic Rats

2019

View full text Add to dashboard Cite

Background: Pre-eclampsia (PE) contributes to the second cause of maternal death in Indonesia. Andaliman is a typical spice of the Batak ethnic in Northern Sumatera Province, Indonesia. This study aimed to explore the potential of novel herbal medicine compound of nanoherbal andaliman and extra virgin olive oil (EVOO) as PE treatment. Methods: Nanoherbal andaliman was generated using High-energy Milling (HEM). The treatments were divided into the following five groups: K- (control): pregnant rats; K+: PE model rats; P1: PE model rats + 0.45 g of EVOO/200 g BW on the 13th–19th day of pregnancy; P2: PE model rats + nanoherbal andaliman 100 mg/200 g BW on the 13th– 19th day of pregnancy; and P3: PE model rats + combination of 0.45 EVOO/200 g BW and nanoherbal andaliman 100 mg/200 g BW on the 13th–19th day of pregnancy. Rats were dissected on the 20th day of pregnancy. The observed parameters were blood pressure, proteinuria, malondialdehyde (MDA), Heat Shock Protein-70 HSP-70 and histology of placenta. Results: A significant difference was noticed (p<0.05) in blood pressure, proteinuria, foetal weight, haematocrit, erythrocytes and trophoblastic cells after the administration of combined nanoherbal andaliman and EVOO. No significant differences in placental weight, foetal number, leukocytes, MDA and HSP-70 were found (p>0.05). Conclusion: The combination of nanoherbal andaliman and EVOO decreased systolic blood pressure and induced the expression of MDA and HSP-70, as well as placental histology of pre-eclamptic rats.

show abstract

“…La prééclampsie est un syndrome spé-cifique de la grossesse, diagnostiquée après 20 semaines d'aménorrhée (SA) chez une femme qui était jusque-là normotendue, elle correspond cliniquement à l'apparition d'une hypertension artérielle associée à une protéinu-rie (> 300 mg/24 heures). L'étiologie de la prééclampsie demeure inconnue à ce jour [2], mais sa physiopathologie impliquerait un trouble de la placentation entraînant une diminution de la perfusion sanguine de l'unité foetoplacentaire, ce qui conduirait à un stress oxydatif suivi d'une dysfonction de l'endothélium maternel [3,4]. La prééclampsie est responsable d'une mortalité maternelle variable selon les pays de 0,1 à 5 % mais surtout d'une morbidité foetale importante par le biais de la préma-turité qu'elle induit souvent et du retard de croissance intra-utérin.…”

Section: Introductionunclassified

Facteurs de risque de la prééclampsie en cas de grossesse unique

Merviel

Touzart

Deslandes

et al. 2008

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

View full text Add to dashboard Cite

Avancées dans la physiopathologie de la pré-éclampsie : place de la réponse inflammatoire

Cited by 16 publications

References 93 publications

Systematic review of observational studies of the impact of cardiovascular risk factors on preeclampsia in sub-saharan Africa

Systematic review of observational studies of the impact of cardiovascular risk factors on preeclampsia in sub-saharan Africa

Study of Combination of Nanoherbal Andaliman (Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) Effects in the Expression of Malondialdehyde (MDA), Heat Shock Protein-70 (HSP70) and Placental Histology of Preeclamptic Rats

Facteurs de risque de la prééclampsie en cas de grossesse unique

Contact Info

Product

Resources

About