Axial Myopia Is Associated with Visual Field Prognosis of Primary Open-Angle Glaucoma

Qiu, Chen; Qian, Sheng; Sun, Xinghuai; Zhou, Chuandi; Meng, Fanrong

doi:10.1371/journal.pone.0133189

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…Literature shows nonsignificant effect of myopia on NTG,[ 16 , 26 , 27 , 29 , 32 , 34 ] and even protective role in some studies. [ 15 , 16 , 34 , 35 ] Caution is needed in a perspective that the progressive course of myopic NTG might differ from nonmyopic NTG. It has been suggested that RNFL defects in myopia might not progress further.…”

Section: Discussionmentioning

confidence: 99%

“…[ 12 , 14 , 37 ] Axial myopia was associated with progression in open-angle glaucoma. [ 15 ] In studies with NTG patients in Japanese population, myopia was a positive factor for glaucoma progression. [ 27 , 34 , 35 ] Meanwhile, there are other studies reporting absence of difference in glaucoma progression between myopic and nonmyopic group.…”

Section: Introductionmentioning

confidence: 99%

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Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

2017

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PurposeTo identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons. Patients and methodsMedical records of NTG patients with asymmetric and symmetric VF losses were retrospectively reviewed. The criterion for asymmetry in VF was 6 dB difference of mean deviation. Refractive error, intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient. Intereye comparison was performed for asymmetric group, symmetric group, and myopic and nonmyopic asymmetric subgroups. ResultsWe included 155 patients; 110 patients in asymmetric group and 45 patients in symmetric group. In intereye comparison for total asymmetric group, refractive error (P = 0.006), initial IOP (P = 0.001), ovality index (P = 0.008), and PPA (P < 0.001) were significantly asymmetric. For myopic subgroup, refractive error (P = 0.004), ovality index (P = 0.001), and PPA (P = 0.003) were significant factors. For nonmyopic subgroup, initial IOP (P = 0.003) and PPA (P = 0.007) were significant factors. Symmetric group showed no significant difference between the eyes. Multivariate analysis demonstrated that refractive error (P = 0.002) and PPA (P = 0.028) were significant factors in myopic subgroup, and initial IOP (P = 0.022) and PPA (P = 0.002) were significant factors in nonmyopic subgroup. ConclusionsIn this intereye comparison, the more myopic eye in myopic NTG patient, and the more pressured eye in nonmyopic NTG patient demonstrated more severe VF loss. Myopic and nonmyopic patients may follow different pathophysiologic processes. Discriminative attentions should be paid to NTG patients by subtypes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

2017

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“…Although elevated intraocular pressure (IOP) is the most common and the only modifiable risk factor of POAG, there are many other factors that can contribute to optic nerve damage or disease progression. [ 4 – 8 ] One hypothetical cause may be insufficient ocular blood flow leading to optic nerve ischemia and glaucomatous optic neuropathy. [ 6 , 9 – 11 ] In animal models, diminished ocular perfusion has been shown to induce retinal ganglion cell loss in spite of a normal IOP.…”

Section: Introductionmentioning

confidence: 99%

Patients with Primary Open-Angle Glaucoma May Develop Ischemic Heart Disease More Often than Those without Glaucoma: An 11-Year Population-Based Cohort Study

Chen

Chu

et al. 2016

PLoS ONE

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ObjectivesTo investigate whether patients with primary open angle glaucoma (POAG) have a higher proportion of ischemic heart disease (IHD) development.DesignA population-based retrospective cohort study, using the National Health Insurance Database (NHID) from 1st January, 2001, to 31st December, 2011, in Taiwan.Methods3510 subjects with POAG were enrolled into the POAG group and 14040 subjects without glaucoma into the comparison group. The comparison group consisted of randomly selected individuals, matched with the POAG group based on age, gender, and index date (date of enrollment) at a ratio of 1:4. The participants of both groups should have no IHD before the index date, and they were followed until the end of 2011 to see whether they had new-onset IHD or not. Kaplan-Meier curves were used to compare the cumulative incidence of IHD between the two groups. Frailty model, a specialized form of Cox regression analysis, was used to estimate the crude and adjusted hazard ratio (HR) of IHD. Analyses were adjusted by age, gender, and systemic comorbidities (i.e. diabetes, hypertension, hyperlipidemia, atrial fibrillation and congestive heart failure).ResultsThe mean age of the cohort was 57.6±11.0 years. There were slightly more males than females (51.6% vs. 48.4%). A log-rank test comparing Kaplan-Meier curves of the two groups revealed a significantly higher cumulative incidence of IHD in the POAG group (p-value<0.001). In the univariate analysis by Frailty model, POAG patients had a significantly higher hazard of IHD (unadjusted HR = 2.32; 95% confidence interval 1.93 to 2.79). After adjustment, results remained significant (adjusted HR = 1.41; 95% confidence interval 1.16 to 1.72).ConclusionPeople with POAG may suffer from IHD more often than those without glaucoma.

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“…Although the pathophysiological mechanism of the impact of myopia on VF progression in OAG is still unknown, one possible hypothesis is that the difference of axial length might positively affect IOP fluctuation. 36 , 37 Axial length is one of the major factors contributing to myopia. Loewen et al 38 reported that basal 24-hour habitual IOP fluctuation was negatively correlated with axial length in a comparison of healthy adults with hyperopia, emmetropia, and myopia.…”

Section: Discussionmentioning

confidence: 99%

Relationship between visual field progression and baseline refraction in primary open-angle glaucoma

Naito¹,

Yoshikawa²,

Mizoue³

et al. 2016

OPTH

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PurposeTo analyze the relationship between visual field (VF) progression and baseline refraction in Japanese patients with primary open-angle glaucoma (POAG) including normal-tension glaucoma.Patients and methodsIn this retrospective study, the subjects were patients with POAG who had undergone VF tests at least ten times with a Humphrey Field Analyzer (Swedish interactive thresholding algorithm standard, Central 30-2 program). VF progression was defined as a significantly negative value of mean deviation (MD) slope at the final VF test. Multivariate logistic regression models were applied to detect an association between MD slope deterioration and baseline refraction.ResultsA total of 156 eyes of 156 patients were included in this analysis. Significant deterioration of MD slope was observed in 70 eyes of 70 patients (44.9%), whereas no significant deterioration was evident in 86 eyes of 86 patients (55.1%). The eyes with VF progression had significantly higher baseline refraction compared to those without apparent VF progression (−1.9±3.8 diopter [D] vs −3.5±3.4 D, P=0.0048) (mean ± standard deviation). When subject eyes were classified into four groups by the level of baseline refraction applying spherical equivalent (SE): no myopia (SE > −1D), mild myopia (−1D ≥ SE > −3D), moderate myopia (−3D ≥ SE > −6D), and severe myopia (−6D ≥ SE), the Cochran–Armitage trend analysis showed a decreasing trend in the proportion of MD slope deterioration with increasing severity of myopia (P=0.0002). The multivariate analysis revealed that baseline refraction (P=0.0108, odds ratio [OR]: 1.13, 95% confidence interval [CI]: 1.03–1.25) and intraocular pressure reduction rate (P=0.0150, OR: 0.97, 95% CI: 0.94–0.99) had a significant association with MD slope deterioration.ConclusionIn the current analysis of Japanese patients with POAG, baseline refraction was a factor significantly associated with MD slope deterioration as well as intraocular pressure reduction rate. When baseline refraction was classified into four groups, MD slope in myopia groups was less deteriorated as compared to those in the emmetropic/hyperopic group.

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Axial Myopia Is Associated with Visual Field Prognosis of Primary Open-Angle Glaucoma

Cited by 19 publications

References 27 publications

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

Patients with Primary Open-Angle Glaucoma May Develop Ischemic Heart Disease More Often than Those without Glaucoma: An 11-Year Population-Based Cohort Study

Relationship between visual field progression and baseline refraction in primary open-angle glaucoma

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