Bacterial Penetration Through Antibiotic‐Loaded Guided Tissue Regeneration Membranes

Cheng, C.S. Agnes; Lee, Ya-Yun; Yang, Lin; Chen, Yen Ting; Hung, Shan Ling; Li, Ling

doi:10.1902/jop.2009.090044

Cited by 28 publications

(31 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, most of the membrane materials used for GTR/GBR, such as collagen, has no inhibitory effect on bacterial growth. Previous studies showed that GTR membranes loaded with antibiotic drugs could delay and/or reduce bacterial penetration30 and enhance the formation of the attachment of PDL cells in the presence of oral pathogens 31. Therefore, using materials that possess antibacterial property as GTR membranes should achieve the same effect as the above and will present more superiority.…”

Section: Periodontal Regenerationmentioning

confidence: 99%

Chitosan as a barrier membrane material in periodontal tissue regeneration

et al. 2012

View full text Add to dashboard Cite

Periodontal regeneration is defined as regeneration of the tooth-supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes.

show abstract

Section: Periodontal Regenerationmentioning

confidence: 99%

Chitosan as a barrier membrane material in periodontal tissue regeneration

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In addition, most of the membranes-also called barriers-protect the defects from the periosteum, which is necessary for angiogenesis. Due to this, wound healing disturbances often occur 11 and reduce the positive effect of augmentation.…”

Section: Guided Tissue Regenerationmentioning

confidence: 99%

“…Wound healing disturbances occur in a high amount of surgical treatments in this position. 2,11 Some authors report on adding platelet-rich plasma (PRP) to the augmentation material to enhance the bone development and healing of the soft tissue. [12][13][14] The use of PRP therapy in surgery was introduced in the late 1990s.…”

Section: Introduction and Scientific Backgroundmentioning

confidence: 99%

Bone Tissue Engineering in Oral Surgery: A New Method of Bone Development in Periodontal Surgery

Schuckert¹,

Osadnik²

2011

Tissue Engineering Part C: Methods

View full text Add to dashboard Cite

This article describes the development of a new surgical approach to periodontal treatment. Twenty patients who suffered from bone defects without existing bony walls due to adult periodontitis were treated in three different groups using methods of bone tissue engineering. At that time no surgical technique existed that could be applied to those patients to generate new bone. The periodontal surgeries were performed between 2004 and 2008. All patients received follow-up examinations at 6, 12, and 24 months after surgical procedure. Measured parameters were compared to baseline. The surgical approach and the augmentation material have been improved based on the results of the previous group. This strategy was applied because of the ethical fact that a medical treatment of patients has to be carried out with the knowledge and experience of previous settings. All groups received recombinant human bone morphogenetic protein 2 and platelet-rich plasma. The above-mentioned procedure had been approved in other indications in the field of oral and maxillofacial surgery. The first group underwent conventional muco-periosteal flap technique and obtained an augmentation with absorbable collagen sponge (ACS). The second and third groups were treated using endoscopically assisted microsurgery due to wound healing disturbances that appeared in the first group. The augmentation was carried out with demineralized bone matrix (DBM) instead of ACS (group 2) or tricalciumphosphate as a further development instead of DBM (group 3). The radiological control 12 months (group 1), 18 months (group 2), and 2 years (group 3) after surgery proved the following results-first group: 1.7 mm (average) vertical bone development (VBD); second group: 2.5 mm (average) VBD; third group: 3.2 mm (average) VBD. These results of single patient treatment open new ways into periodontal surgery. They have to be confirmed by prospective case series and multicenter studies.

show abstract

“…One study assessed explicitly the penetration of prokaryotic cells, namely of S. mutans and A. actinomycetemcomitans through guided tissue regeneration (GTR) membranes using a device consisting of an inner tube and an outer bottle filled with culture media. The study showed differences in the behavior of the evaluated membranes and -not surprisingly -that an incorporation of an antibiotic into the membrane was effective in controlling bacterial percolation [6]. According to the authors' knowledge studies using such models are, however, still lacking the evaluation of eukaryotic cells.…”

Section: Introductionmentioning

confidence: 96%