Baicalein is neuroprotective in rat MCAO model: Role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2

Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice

“…Mounting reports have shown that it has various biological activities including antiviral, antioxidant, anti-inflammatory, neuroprotective and anticancer activities (Shen et al, 2003;Bochorakova et al, 2003;Cui et al, 2010;Ikemoto et al, 2000). A previous report has already speculated that baicalein could activated AMPK in human tumor cells (Ding et al, 2011).…”

The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain

“…Although the pathophysiological mechanisms of ICH are still unclear, inflammatory reaction and oxidative stress are two major factors leading to brain injuries after ICH (Wu et al, 2002;Nakamura et al, 2005;Zhang et al, 2006;Wang, 2010). Accumulating evidences have showed that Toll-like receptor4 (TLR4), nuclear factor kappa-B (NF-kB), 12/15 lipoxygenase (12/15-LOX), phosphorylated p38 mitogen activated protein kinase (phospho-p38 MAPK), and cytosolic phospholipase A2 (cPLA2) are major mediators responsible for inflammatory and oxidative brain damages after ICH (Hickenbottom et al, 1999;Zhao et al, 2007;Wagner, 2007;Nito et al, 2008;Teng et al, 2009;He et al, 2009;Cui et al, 2010aCui et al, , 2010b. Thus, any interventions that inhibit TLR4, NF-kB, 12/15-LOX, phospho-p38 MAPK and cPLA2, may be expected to reduce the severity of hemorrhagic brain injury.…”

Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative–nitrosative stress and p38 MAPK activation

“…Baicalein (5,6,7-trihydroxyflavone), a flavonoid originally isolated from the roots of Scutellaria baicalensis , has been employed for many centuries in traditional Chinese herbal medicine as antibacterial and antiviral remedy (Huang et al, 2005). In addition to its antioxidant properties, baicalein has been described to inhibit xanthine oxidase, 12/15-lipoxygenase, p38 MAPK, cytosolic phospholipase A2, inflammatory response, as well as sorbitol accumulation in animal and cell culture models of chronic disease (Huang et al, 2005; Cui et al, 2010; Zhou and Zhang 1989). Reports suggest good efficacy of baicalein against experimental renin-dependent hypertension (Huang et al, 2005), endothelial dysfunction associated with cardiovascular diseases (Huang et al, 2005), cerebral ischemia (Pallast et al, 2010), cancer (Androutsopoulos et al, 2010), Parkinson disease (Hong et al, 2008), dermatitis (Yun et al, 2010), liver fibrosis (Sun et al, 2010), as well as pain of inflammatory origin (Yoo et al, 2009).…”