Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats

Yağcı, Gökhan; Gül, Hüsamettin; Şimşek, Abdurrahman; Buyukdogan, Varol; Öngürü, Önder; Zeybek, Nazif; Aydın, Ahmet; Balkan, Müjdat; Yıldız, Oğuzhan; Şen, Derviş

doi:10.1007/s00535-003-1287-4

Cited by 48 publications

(29 citation statements)

References 32 publications

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“…These functions were recovered with NAC treatment despite ongoing pancreatitis. Yagci et al [8] found that leucocyte infiltration and production of lipid peroxidation were lower in NAC-treated group. Due to direct scavenging effects of NAC on ROS, higher remaining nitric oxide may have been beneficial to regulation of microcirculation in the pancreatic tissue in NAC-treated group.…”

Section: Discussionmentioning

confidence: 95%

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Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Atayoğlu¹,

Gurleyik

Demirel³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Systemic inflammatory responses and extrapancreatic vital organ impairment are mediated by activated neutrophil functions and products, such as oxygen-derived free radicals, in patients with acute pancreatitis (AP). The present study is an examination of effects of an antioxidant, N-acetylcysteine (NAC), on local and systemic histopathological changes and neutrophil functions during AP.

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Section: Discussionmentioning

confidence: 95%

“…It has been investigated as an antioxidant compound in various experimental studies. [7,8] Various antioxidants have no useful effects in taurocholate-induced pancreatitis, but NAC was found to be beneficial. Therefore, OFR formation may be an important factor in taurocholate-induced pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Atayoğlu¹,

Gurleyik

Demirel³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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“…In addition, in the NAC-treated rats, while serum nitrite/nitrate levels were significantly increased, serum concentration of the lipid peroxidation product was significantly decreased. The beneficial effect of NAC may result from its antioxidant activity and the production of and/or inhibition of degradation of nitric oxide [5] . In a similar study, Vaquero et al [21] have demonstrated that treatment with NAC reduces neutrophil infiltration and mRNA expression for IL-6, cytokines and inducible nitric oxide synthase in pancreatic tissue, by inhibition of NF-κB activity.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, pathogenesisoriented treatments of AP have gained importance. Therefore, new experimental studies have focused on pathophysiological mechanisms such as oxidative stress and inflammatory cytokines [5,6] . Propolis is a natural substance that is produced by honeybees from the gum of various plants.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of caffeic acid phenethyl ester oncerulein-induced acute pancreatitis

Büyükberber

Savaş²,

Bağcı³

et al. 2009

WJG

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AIM:To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP). METHODS:Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS:In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased significantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathological results and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.

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“…Lipid peroxidation results in loss of the membrane fluidity and integrity, leading to cell death. Numerous antioxidants have recently been examined for their protective properties against oxidative damage in acute pancreatitis and have been shown to moderate the changes in several parameters of the disease [7][8][9][10] . We presumed that a compound with strong antioxidant properties and also anti-inflammatory features might exert a beneficial effect on the outcome of severe experimental pancreatitis.…”

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confidence: 99%

Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

Szabolcs¹,

Hegyi²,

Pápai³

et al. 2004

Z Gastroenterol

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tonin given in advance of L-Arg significantly reduced the pancreatic CAT activity relative to that in the rats treated with L-Arg alone. In the liver, L-Arg significantly increased the lipid peroxidation level, and the glutathione peroxidase and Cu/Zn-SOD activities, whereas the Mn-SOD activity was reduced as compared to the control rats. Melatonin pre-treatment prevented these changes. CONCLUSION:Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis. INTRODUCTIONAcute necrotizing pancreatitis is a disease with a high mortality and no efficient treatment is available for it at present. Oxygen-and nitrogen-derived free radicals (FRs) and lipid peroxidation play an important role in the development of local inflammation and systemic complications during acute pancreatitis [1][2][3][4][5][6] . They damage the lipid membranes, structural and enzymatic proteins and DNA of the cells. The major target of FRs is polyunsaturated fatty acids of the lipid-rich membranes. Lipid peroxidation results in loss of the membrane fluidity and integrity, leading to cell death. Numerous antioxidants have recently been examined for their protective properties against oxidative damage in acute pancreatitis and have been shown to moderate the changes in several parameters of the disease [7][8][9][10] . We presumed that a compound with strong antioxidant properties and also anti-inflammatory features might exert a beneficial effect on the outcome of severe experimental pancreatitis.The pineal product, melatonin, is known to play a rolePO Box 2345, Beijing 100023, China World J Gastroenterol 2006 January 14; 12(2):251-258 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com © 2006 The WJG Press. All rights reserved. BASIC RESEARCHEffect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats Abstract AIM: To determine the effect of melatonin pre-and post-treatment on the severity of L-arginine (L-Arg) -induced experimental pancreatitis in rats. METHODS:Male Wistar rats (25) were divided into five groups. Those in group A received two injections of 3.2 g/kg body weight L-Arg i.p. at an interval of 1 h. In group MA, the rats were treated with 50 mg/kg body weight melatonin i.p. 30 min prior to L-Arg administration. In group AM, the rats received the same dose of melatonin 1 h after L-Arg was given. In group M, a single dose of melatonin was administered as described previously. In group C the control animals received physiological saline injections i.p. All rats were exsanguinated 24 h after the second L-Arg injection.RESULTS: L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio (pw/bw), the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values. Elevation of the serum am...

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Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats

Cited by 48 publications

References 32 publications

Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Therapeutic effect of caffeic acid phenethyl ester oncerulein-induced acute pancreatitis

Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

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