Benign Breast Disease in Women

Stachs, Angrit; Stubert, Johannes; Reimer, Toralf; Hartmann, Steffi

doi:10.3238/arztebl.2019.0565

Cited by 112 publications

(142 citation statements)

References 90 publications

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“…FAs with no atypical findings can be monitored with mammography or ultrasound twice a year, for two years and, then once a year. 6 Performing a percutaneous biopsy is recommended to confirm the histological diagnosis if the following findings are present: inconclusive ultrasound findings (BI-RADS 4); evidence of growth trend (clinically and ultrasonographically); new palpable mass during menopause; solid mass found in a patient with risk factors (positive family risk and/or BRCA mutation); and mammography showing mass with suspicious micro-calcifications 20 . In this way, excisional biopsy is indicated when histopathological biopsy reveals a high-risk lesion to rule out possible malignancy.…”

Section: Discussionmentioning

confidence: 99%

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

Cardoso¹,

Schröder²,

Zimermann³

et al. 2020

Mastology

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Fibroadenomas (FAs) are benign fibro-epithelial tumours of the breast characterized by being biphasic and having stromal and epithelial components. It is estimated that FAs affect more than 20 percent of the general population aged 16–40 years old. Complex FAs are a sub-type of fibroadenoma presenting one or more pathological characteristics, such as epithelial calcifications, apocrine metaplasias, sclerosing adenoma and cysts larger than 3 mm. According to studies elsewhere, women with complex FAs are 3.1 times more likely to develop breast cancer. The objective of the present study was to map the scientific production of articles on complex FA in the international literature. The ISI Web of Knowledge (Web of Science), one of the main scientific databases in the world, was searched with the following terms: (“complex” and “fibroadenoma”) or (“fibroadenoma” and “complex”). Only articles published between 1981 and 2019 were considered for a bibliometric review, in which 160 articles from 126 different periodicals were identified after using refinement filters. Moreover, a clinical case was also discussed based on the patient’s medical record and interview.

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Section: Discussionmentioning

confidence: 99%

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

Cardoso¹,

Schröder²,

Zimermann³

et al. 2020

Mastology

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“…Фізіологія і патологія молочних залоз (МЗ) завжди були одним із найскладніших напрямків медичної науки і практики. Це комплексна проблема, наукові, лікувально-діагностичні, методологічні та організаційні аспекти якої мають яскраво виражений міждисциплінарний характер [1][2][3][4][5][6][7].…”

Section: вступunclassified

Preconception prevention of lactation disorders in women with fibrocystic breast disease

Zhuk

Кондратюк

Kondratiuk

2021

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Study objective: to establish the clinical efficacy of 1.0% micronized progesterone gel Progestogel® at the preconception stage in order to prevent lactation disorders in women with fibrocystic breast disease (FBD).Materials and methods. The main group consisted of 30 women with diffuse forms of FBD who applied on each mammary gland 2.5 g 1.0% micronized progesterone gel Progestogel® for 6 months daily at the stage of pregnancy planning. The comparison group included 30 women with diffuse forms of FBD who did not use Progestogel® at the stage of pregnancy planning. The control group consisted of 30 healthy pregnant women without pathological changes in mammary glands. Stages of observation included preconception period, pregnancy, postpartum period, lactation period and long-term period (6 month after the end of lactation).Results. Preconception preparation with transdermal 1.0% micronized progesterone gel Progestogel® in patients with diffuse forms of FBD promoted long-term breastfeeding and a regressive course of the breast pathological process. Examination of this group of patients in the long-term period (6 month after the end of lactation) showed no clinical manifestations of the breast disease (pain syndrome and edema) in 24 (80.0%) women and regression of ultrasound signs of FBD in 21 (70.0%) patients. Manifestation of both clinical and echographic signs of the breast disease was diagnosed in 26 (86.7%) women in the comparison group. Transdermal 1.0% micronized progesterone gel in the preconception preparation associated with no complications of the early lactation period in 83.3% of patients and provided a long (12 months) lactation process in 66.7% of patients.Conclusion. Progestogel® is an effective pathogenically substantiated means of safe therapy for diffuse forms of FBD. The protective effect of 1.0% micronized progesterone gel Progestogel® associated with regression of clinical and echographic manifestations of FBD in 80.0% of women.

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“…Data di Amerika menunjukkan lebih dari 1 juta wanita memiliki hasil biopsi payudara jinak. Hanya 3 -6 % kasus disebabkan oleh kanker payudara (Stachs et al 2019;Visscher et al 2014). Di Indonesia, kanker payudara menempati urutan pertama dengan estimasi insiden 40 per 100.000 perempuan.…”

Section: Pendahuluanunclassified

Pengaruh Ekstrak Daun Sirsak terhadap Ekspresi CD8 pada Populasi Limfosit Tumor Payudara Tikus Sparaque Dawley

2020

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Perubahan klinis pada payudara sebagian besar bersifat jinak, hanya 3 – 6% yang merupakan keganasan payudara. Namun demikian, kanker payudara menjadi perhatian utama mengingat angka kejadian yang terus menerus meningkat serta morbiditas dan mortalitas yang tinggi. Pengobatan kanker hingga saat ini masih menjadi tantangan. Hal ini membuka peluang penelitian terapi kanker terutama dari bahan herbal. Daun sirsak telah banyak digunakan masyarakat secara tradisional untuk pengobatan tumor. Di samping itu berbagai studi juga telah menunjukkan efek sitotoksik tanaman ini terhadap berbagi cell line kanker. Namun demikian belum ada penelitian yang menganalisis efek ekstrak daun sirsak terhadap populasi limfosit di lingkungan mikro tumor terutama yang berfungsi pada respon imun anti tumor. Penelitian ini bertujuan untuk mengetahui infiltrasi sel limfosit T CD8 pada jaringan tumor yang payudara tikus Sparaque Dawley yang diberikan ekstrak etanol daun sirsak. Ekspresi CD8 dianalisis melalui pewarnaan imunohistokimia. Ekspresi CD8 positif ditandai dengan warna coklat pada sitoplasma sel limfosit, selanjutnya ekspresi CD8 dari setiap sampel dihitung pada 3 lapang pandang dengan high-power field, kemudian ditentukan nilai rata-ratanya. Pewarnaan HE menunjukkan variasi infiltrasi limfosit pada nodul payudara tikus SD. Rata-rata ekspresi CD8 kelompok kontrol menunjukkan hasil lebih tinggi dibandingkan kelompok perlakuan. Namun demikian, hasil uji komparasi menunjukkan tidak ada perbedaan bermakna (p > 0,05) antara ekspresi CD8 kelompok kontrol dengan perlakuan. Hasil ini menunjukkan bahwa pemberian ekstrak daun sirsak tidak menyebabkan perbedaan bermakna ekspresi CD8 pada populasi limfosit yang menginfiltrasi tumor payudara tikus SD.

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Benign Breast Disease in Women

Cited by 112 publications

References 90 publications

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

Complex fibroadenoma: bibliometric literature review and presentation of a clinical case

Preconception prevention of lactation disorders in women with fibrocystic breast disease

Pengaruh Ekstrak Daun Sirsak terhadap Ekspresi CD8 pada Populasi Limfosit Tumor Payudara Tikus Sparaque Dawley

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