2010
DOI: 10.1016/j.ejmech.2010.02.022
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Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: Synthesis, antitumor evaluation in vitro and crystal structure determination

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Cited by 109 publications
(57 citation statements)
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“…In addition, this family of compounds have been proved for having prominent biological properties as antifungal, antitumor, and antibacterial activities [3][4][5][6][7], as well as applications for the design of dendrimers [8] and uorescent probes for visualizing endogenous thiols in living cells [9,10]. They have also been reported in the literature as versatile building-blocks for molecules with potential biological or pharmaceutical applications [11][12][13][14][15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, this family of compounds have been proved for having prominent biological properties as antifungal, antitumor, and antibacterial activities [3][4][5][6][7], as well as applications for the design of dendrimers [8] and uorescent probes for visualizing endogenous thiols in living cells [9,10]. They have also been reported in the literature as versatile building-blocks for molecules with potential biological or pharmaceutical applications [11][12][13][14][15][16][17].…”
Section: Discussionmentioning
confidence: 99%
“…[13] . Many researchers study imidazole derivative compounds properties such as, Gaba M. etal [14] study Novel 5-Substituted -1-(phenylsulphonyl) methyl benzimidazole derivatives, they have synthesized and screened for their antiinflammatory as well as analgesic activity, in other study Hranjec M etal [15] ., showed newly synthesized benzimidazole derivatives exerted pronounced antiproliferative activity. Among a synthesized series of aminothiazolo [3,2-a] benzimidazole derivatives Nacetylaminothiazolo [3,2-a] benzimidazole -2-carbonitrile revealed significant in vitro antiproliferative activity which attributed to its ability to arrest G2/M phase and to induce apoptosis in time dependant manner [16] .…”
Section: Resultsmentioning
confidence: 99%
“…The growth inhibition activity was assessed as described previously [ 7,8,15,16,20 ]. The panel cell lines were inoculated onto a series of standard 96-well microtiter plates on day 0, at 1×10 4 to 3×10 4 cells/mL, depending on the doubling times of a specific cell line.…”
Section: Antitumor Evaluation Assaymentioning
confidence: 99%
“…20 Prompted by the results from the previously reported studies, we set out to explore and synthesize novel acyclic nitro 4, 5, 17-20 and cyclic nitro 6, 7, and 21-24 and amino 8-9 and 26-28 substituted benzimidazole [1,2-a]quinolines with the substituents on the different positions of the condensed tetracyclic ring. The hydrochloride salts 10-11 and 29-32 were prepared to improve their solubility in water ( Figure 1).…”
Section: Introductionmentioning
confidence: 99%