Bevacizumab plus high-dose ifosfamide, etoposide and carboplatin (HD-ICE) as third-line salvage chemotherapy induced an unexpected dramatic response in highly platinum refractory germ-cell cancer

Bevacizumab in combination with sequential high-dose chemotherapy in solid cancer, a feasibility study

“…This assumption was underlined by the observation of a potential reversal of chemotherapy resistance by the addition of bevacizumab in one case from our institution in a patient with highly refractory GCC. 22 The observed response rate in our study in patients with sarcoma was 30.8%. These results are very difficult to compare with other results obtained with HDCT because Table 3 Description of all patients including response to previous treatment, response, PFS to HD-ICE+ bevacizumab mostly patients with chemosensitive, non-refractory sarcomas were included in these trials.…”

Ovarian Yolk Sac Tumor

“…High-dose chemotherapy combined with autologous stem cell transplantation may provide an opportunity for complete tumor remission. 3,17,18 In our study, 1 patient had a para-aortic lymph node recurrence at 6 months after discontinuation of the BEP regimen and 10.7 months after the initial diagnosis. She was successfully salvaged with another 4 cycles of BEP regimen.…”

GAMEC – a new intensive protocol for untreated poor prognosis and relapsed or refractory germ cell tumours

“…Other groups have reported encouraging results using alternative agents, for instance cisplatin and epirubicin (Bedano et al, 2005), and recently an interesting case report suggested that antiangiogenic agents may also have a role (Voigt et al, 2006).…”