Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts

Lee, C. W.; Kim, H. S.; Choi, Ho Jin; Kim, J. W.; Kim, H. K.; Moon, Hyung-In; Woo, E.

doi:10.1055/s-0028-1084265

Cited by 5 publications

(5 citation statements)

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“…Thus, ultraviolet radiation was proved to cause several human cancers [22][23], especially skin cancer [24] and breast cancer [22][23][24][25]. In the study, however, amentoflavone was observed to be a treating agent for the carcinogenesis [26][27]. Therefore, it can be induced that the anti-cancer effect of amentoflavone could be partly attributed to its protective effect against DNA oxidative damage and antioxidant mechanism.…”

Section: Resultsmentioning

confidence: 92%

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Li¹,

Wang²,

Han³

et al. 2014

Turk J Bioch

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Section: Resultsmentioning

confidence: 92%

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Li¹,

Wang²,

Han³

et al. 2014

Turk J Bioch

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“…Selaginella tamariscina has been a source of several drugs with anti-bacterial and antifungal activities such as amentoflavone [58], isocryptomerin [59][60][61], or with antitumor effects such as sterols [62] and biflavonoids [63]. Alpinia galanga crude extracts have been shown to have antibacterial activities [64] which seem to be enhanced in combination with other plants such as rosemary and lemon iron bark [65].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

et al. 2011

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Abstract:In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)-a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr) cells, while Evodia lepta, Hedyotis Moreover, among fifteen water extracts that combined high antiproliferative activity (IC 50 0.5-20 µg/mL) and low acute in vitro toxicity (0-10% reduction in cell viability at IC 50 ), Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

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“…14) In the past decade, a number of papers have reported the isolation of MMP-1 inhibitors from plant resources. Examples include aucubin from Eucommia ulmoides cortex, 15) tectoridin-4′-O-β-D-glucoside from aerial parts of Viola hondoensis, 16) sumaflavone and amentoflavone from whole plant of Selaginella tamariscina, 17) styraxjaponoside B and erythrodiol-3-acetate from Styrax japonica stem, 18,19) xanthorrhizol from Curcuma xanthorrhiza rhizome, 14) caffeic acid and chlorogenic acid from Coffea arabica leaf, 20) panduratin A and 4-hydroxypanduratin A from Kaempferia pandurata rhizome, 21,22) Punica granatum extract, 23) Emblica officinalis extract 24) and Sanguisorba officinalis extract. 25) Among these plants, a few plant such as Coffea arabica leaf extract 20) is known to have HLE inhibitory activity.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-1 Inhibitory Activities of Morinda citrifolia Seed Extract and Its Constituents in UVA-Irradiated Human Dermal Fibroblasts

Masuda

Murata

Naruto

et al. 2012

Biological & Pharmaceutical Bulletin

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The objective of this study was to examine whether a 50% ethanolic extract (MCS-ext) of the seeds of Morinda citrifolia (noni) and its constituents have matrix metalloproteinase-1 (MMP-1) inhibitory activity in UVA-irradiated normal human dermal fibroblasts (NHDFs). The MCS-ext (10 μg/mL) inhibited MMP-1 secretion from UVA-irradiated NHDFs, without cytotoxic effects, at 48 h after UV exposure. The ethyl acetatesoluble fraction of MCS-ext was the most potent inhibitor of MMP-1 secretion. Among the constituents of the fraction, a lignan, 3,3′-bisdemethylpinoresinol (1), inhibited the MMP-1 secretion at a concentration of 0.3 μM without cytotoxic effects. Furthermore, 1 (0.3 μM) reduced the level of intracellular MMP-1 expression. Other constituents, namely americanin A (2), quercetin (3) and ursolic acid (4), were inactive. To elucidate inhibition mechanisms of MMP-1 expression and secretion, the effect of 1 on mitogen-activated protein kinases (MAPKs) phosphorylation was examined. Western blot analysis revealed that 1 (0.3 μM) reduced the phosphorylations of p38 and c-Jun-N-terminal kinase (JNK). These results suggested that 1 suppresses intracellular MMP-1 expression, and consequent secretion from UVA-irradiated NHDFs, by down-regulation of MAPKs phosphorylation.Key words Morinda citrifolia; noni seed; matrix metalloproteinase-1 inhibitor; photoaging; 3,3′-bisdemethylpinoresinol Normal human dermis primarily consists of an extracellular matrix of connective tissue, of which the most abundant protein is collagen. Chronic UV exposure denatures collagen and elastic fibers in the dermis and induces wrinkles, thereby promoting photoaging.1) UV induces the production of matrix metalloproteinases (MMPs) by activating intracellular signal transcription pathways, including mitogen-activated protein kinase (MAPK) p38 and c-Jun-N-terminal kinase (JNK). 2)Activation of the phosphorylation of MAPKs may lead to an over expression of c-Jun and c-Fos. This results in induction of activator protein-1 (AP-1), which, in turn, up-regulates expression of MMPs.3) MMPs are a family of structurally related matrix degrading enzymes that are associated with various destructive processes, including inflammation, tumor invasion and skin aging.1) MMPs are subdivided in different types at least over 20 members.4) Among them, MMP-1, secreted from human skin fibroblasts, is mainly responsible for the degradation of dermal collagen in the photoaging process of human skin.5) Neutrophils play an important role during the process of photoaging, which are set in motion by UV irradiation. The neutrophils infiltrate into the skin and release several active enzymes, such as MMPs and human leukocyte elastase (HLE).6) HLE cleaves the helix structure of type I collagen and then degrades elastic fiber in human skin. 7) HLE also directly activates MMP-1 from human dermal fibroblasts. 8)Thus, it is expected that MMP-1 inhibitors and/or HLE inhibitors may be useful for the prevention of photoaging of human skin.Morinda citrifolia L. (Rubiaceae), commonly kno...

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Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts

Cited by 5 publications

References 0 publications

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

Matrix Metalloproteinase-1 Inhibitory Activities of Morinda citrifolia Seed Extract and Its Constituents in UVA-Irradiated Human Dermal Fibroblasts

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