Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice

Kusumoto, Yukie; Irie, Junichiro; Iwabu, Kaho; Tagawa, Hirotsune; Itoh, Aki; Kato, Masakatsu; Kobayashi, Nana; Tanaka, Kumiko; Kikuchi, R.; Fujita, Masataka; Nakajima, Yuya; Morimoto, Kohkichi; Sugizaki, Taichi; Yamada, Satoru; Kawai, Takeshi; Watanabe, Mitsuhiro; Oike, Yuichi; Itoh, Hiroshi

doi:10.1016/j.metabol.2017.02.011

Cited by 29 publications

(17 citation statements)

References 20 publications

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“…Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis and preventing the buildup of toxic metabolites, as well as the accumulation of cholesterol [15]. Studies have demonstrated that bile acids are closely associated with the intestinal microbiota, which intimately affects gut hormones [16].…”

Section: Introductionmentioning

confidence: 99%

Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes

Zhou

Tang

et al. 2020

Journal of Diabetes Research

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Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health. Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis. Furthermore, increasing studies suggest that bile acids may regulate glucose tolerance, insulin sensitivity, and energy metabolism, suggesting that bile acids may represent a potential therapeutic target for T2DM. This study summarizes the metabolism of bile acids and, more importantly, changes in their concentrations, constitution, and receptors in diabetes. Furthermore, we provide an overview of the mechanisms underlying the role of bile acids in glucose and lipid metabolism, as well as the occurrence and development of T2DM. Bile acid-targeted therapy may represent a valid approach for T2DM treatment.

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Section: Introductionmentioning

confidence: 99%

Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes

Zhou

Tang

et al. 2020

Journal of Diabetes Research

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“…Several active anti-obesity ingredients present in plants have also been identified, such as Kefir peptides from lucid ganoderma and peptide 2 from Grifola frondosa. Many soy peptides have been identified to lower cholesterol and triglycerides, which can suppress fat synthesis and storage in different experimental systems [9]. These plant extracts and natural compounds have considerable potential to be further developed into effective therapies for LMD [10].…”

Section: Introductionmentioning

confidence: 99%

Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

Hua

Xiong

et al. 2018

IJMS

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Lipid metabolism disorder (LMD) is a public health issue. Spirulina platensis is a widely used natural weight-reducing agent and Spirulina platensis is a kind of protein source. In the present study, we aimed to evaluate the effect of Spirulina platensis protease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Our study showed that SPPH decreased the levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), and aspartate transaminase (AST), but increased the level of high-density-lipoprotein cholesterol (HDL-c) in serum and liver. Moreover, SPPH had a hypolipidemic effect as indicated by the down-regulation of sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl CoA carboxylase (ACC), SREBP-1c, and peroxisome proliferator-activated receptor-γ (PPARγ) and the up-regulation of adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) and peroxisome proliferator-activated receptorα (PPARα) at the mRNA level in liver. SPPH treatment enriched the abundance of beneficial bacteria. In conclusion, our study showed that SPPH might be produce glucose metabolic benefits in rats with diet-induced LMD. The mechanisms underlying the beneficial effects of SPPH on the metabolism remain to be further investigated. Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals.

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“…Likewise, other microbial products, such as betaine, trimethylamine N-oxide (TMAO) and choline, are also involved in the development of cardiovascular diseases (Wang et al, 2011). Bile acids, which are major intestinal metabolites, may have beneficial effects on obesity and hepatic insulin sensitivity (Tagawa et al, 2015;Kusumoto et al, 2017). SCFAs are a group of major fermentation products from dietary fibers by microorganisms in the gut, serve as histone deacetylases inhibitors and GPCRs ligands governing host metabolism and immunity (Chung et al, 2016;Koh et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis

Xiao

Dong

et al. 2020

Front. Microbiol.

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Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S ribosomal RNA high-throughput sequencing analysis indicated that P80 consumption altered the abundance and composition of the gut microbiota, leading to severe radiation-induced GI tract injury. Mice harboring fecal microbes from P80-treated mice were highly susceptible to irradiation, and antibiotics-challenged mice also represented more sensitive to radiation following P80 treatment. Importantly, butyrate, a major metabolite of enteric microbial fermentation of dietary fibers, exhibited beneficial effects against P80 consumption-aggravated intestinal toxicity via the activation of G-protein-coupled receptors (GPCRs) and maintenance of the intestinal bacterial composition in irradiated animals. Moreover, butyrate had broad therapeutic effects on common radiation-induced injury. Collectively, our findings demonstrate that P80 are potential risk factors for cancer patients during radiotherapy and indicate that butyrate might be employed as a therapeutic option to mitigate the complications associated with radiotherapy.

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Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice

Cited by 29 publications

References 20 publications

Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes

Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes

Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis

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