Bilirubin and its Oxidation Products Damage Brain White Matter

Lakovic, Katarina; Ai, Jinglu; D’Abbondanza, Josephine A; Tariq, Asma; Sabri, Mohammed; Alarfaj, Abdullah K; Vasdev, Punarjot; Macdonald, R. Loch

doi:10.1038/jcbfm.2014.154

Cited by 37 publications

(31 citation statements)

References 40 publications

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“…Recent evidence suggests that bilirubin is toxic to both myelinated and unmyelinated axons in vitro and in vivo, although unmyelinated axons seem more susceptible to damage in vivo [44]. Decreased thickness of the myelin sheets was observed in brain slices treated with UCB.…”

Section: Mechanisms Of White Matter Injury By Bilirubinmentioning

confidence: 94%

Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Brites

Fernandes

2015

Seminars in Fetal and Neonatal Medicine

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Section: Mechanisms Of White Matter Injury By Bilirubinmentioning

confidence: 94%

Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Brites

Fernandes

2015

Seminars in Fetal and Neonatal Medicine

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“…These results suggested that necroptosis is one potential mechanism of ICH-induced white matter injury (Xie et al, 2014). The effects of blood breakdown products on ICH-induced white matter injury have recently been investigated (Lakovic et al, 2014). According to that study, bilirubin affects white matter structural integrity and function, and bilirubin oxidation products are responsible for the bilirubin toxicity.…”

Section: Effects Of Ich On Neural Cell Typesmentioning

confidence: 99%

“…According to that study, bilirubin affects white matter structural integrity and function, and bilirubin oxidation products are responsible for the bilirubin toxicity. Marked microglia activation has been observed in damaged white matter at post-ICH day 3 to 7 (Lakovic et al, 2014; Wasserman and Schlichter, 2008). …”

Section: Effects Of Ich On Neural Cell Typesmentioning

confidence: 99%

Intercellular cross-talk in intracerebral hemorrhage

et al. 2015

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Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high mortality and morbidity. Currently, there are few treatment strategies for ICH-induced brain injury. A recent increase in interest in the pathophysiology of ICH, has led to elucidation of the pathways underlying ICH-induced brain injury, pathways where intercellular and hematoma to cell signaling play important roles. In this review, we summarize recent advances in ICH research focusing on intercellular and hematoma:cell cross-talk related to brain injury and recovery after ICH.

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“…5 In the case of neonates, the possible alternative for invasive blood sampling is a transcutaneous bilirubinometer (BiliChek and JM-103 are the commercial versions of the device) that provides instantaneous cutaneous bilirubin concentration (TcB). 14 In the case of Hepatitis E infection in pregnant women, associated hyperbilirubinemia itself is found to increase the risk of preterm delivery. Since the discovery of the method in 1980, 8 several more devices have been developed in order to improve the accuracy of the device.…”

Section: Introductionmentioning

confidence: 99%

Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects

et al. 2015

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Jaundice is one of the notable markers of liver malfunction in our body, revealing a significant rise in the concentration of an endogenous yellow pigment bilirubin. We have described a method for measuring the optical spectrum of our conjunctiva and derived pigment concentration by using diffused reflection measurement. The method uses no prior model and is expected to work across the races (skin color) encompassing a wide range of age groups. An optical fiber-based setup capable of measuring the conjunctival absorption spectrum from 400 to 800 nm is used to monitor the level of bilirubin and is calibrated with the value measured from blood serum of the same human subject. We have also developed software in the LabVIEW platform for use in online monitoring of bilirubin levels in human subjects by nonexperts. The results demonstrate that relative absorption at 460 and 600 nm has a distinct correlation with that of the bilirubin concentration measured from blood serum. Statistical analysis revealed that our proposed method is in agreement with the conventional biochemical method. The innovative noncontact, low-cost technique is expected to have importance in monitoring jaundice in developing/underdeveloped countries, where the inexpensive diagnosis of jaundice with minimally trained manpower is obligatory.

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Bilirubin and its Oxidation Products Damage Brain White Matter

Cited by 37 publications

References 40 publications

Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities

Intercellular cross-talk in intracerebral hemorrhage

Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects

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