Binding Studies and Effect of Light on the Conductance of Intercalated Curcumin into DNA

Abstract

Curcumin is one of the most valuable ingredients for scientific research in view of medicinal and therapeutic importance. Curcumin is reported to have antitumor and anticancer activities. It can easily be extracted from Turmeric by solvent extraction methods. At first, dye was extracted through reflux and trituration process. Then curcumin was isolated from dye using column chromatography, which was investigated by infrared spectroscopy and melting point. Curcumin formed a complex with Ce 3+ , Ce(C 21 H 20 O 6 ) n , which was confirmed by comparing the IR spectrum of complex with that of ligand. We observed the effect of light on the curcumin intercalated into DNA and found that the electrons in curcumin excited by absorption of light and the conductance of the solution increased gradually when irradiated by UV-light. The result may indicate the electron conducting property of DNA in solution. We focused on the binding of curcumin with DNA. Our investigations also showed that both curcumin and Ce 3+ complex have luminescence properties upon irradiation by UV-light.

Synthesis and Characterization of Metal Complexes Containing Curcumin (C₂₁H₂₀O₆) and Study of their Anti-microbial Activities and DNA-binding Properties

“…We have reported binding studies and effect of light on the conductance of intercalated curcumin into DNA [14]. In our recent studies on DNA-metal complexes (with phendione) interactions, DNA binding and damaging properties of complexes have been discussed [13].…”

Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

“…Anti-bacterial study of the synthesized complexes indicated that these complexes had anti-bacterial activity against Klebsiella pneumonia and Escherichia coli. [16,17]. Also, curcumin with other transition metals ions Ni(II), Zn(II), Pd(II), Fe(III), Cr(III), Mn(II), can form strong chelates [10,[18][19][20].…”

Innovative Bacterial Removal Technique Using Green Synthetic Nano Curcumin Zinc (II) Complex for Sustainable Water Resource Management

“…Curcumin acts as a good reducing agent due to its ability to bind with different types of metals to form stable complexes owing to the presence of the bi keto group. Curcumin metal complexes have demonstrated effective antibacterial activity against Klebsiella pneumonia and Escherichia coli [24,25]; H. bacillus and Bacilus Subtilis [26]; and Salmonella and Staphylococcus aureus [27].…”